Ocular association of HIV infection in the era of highly active antiretroviral therapy and the global perspective

Clinical and Experimental Ophthalmology

Volumn 33, Issue 3, 2005, Pages 317-329

  Ng, Weng T ^a   Versace, Patrick ^b  

^a QUEEN ELIZABETH HOSPITAL   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Global perspective; HAART; HIV AIDS infection; Immune recovery uveitis; Ocular ophthalmic association

Indexed keywords

ACICLOVIR; ALBENDAZOLE; ANTIINFECTIVE AGENT; ANTITHROMBOCYTIC AGENT; ATOVAQUONE; CIDOFOVIR; CLINDAMYCIN; CORTICOSTEROID; FOLINIC ACID; FOMIVIRSEN; FOSCARNET; FUMAGILLIN; GANCICLOVIR; PROTEINASE INHIBITOR; PYRIMETHAMINE; RIFABUTIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; STEROID; SULFADIAZINE; TRIAMCINOLONE; VALGANCICLOVIR; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ATYPICAL MYCOBACTERIOSIS; CATARACT; CHOROIDITIS; CLINICAL TRIAL; CYTOMEGALOVIRUS INFECTION; ENDOPHTHALMITIS; EYE INFECTION; HERPES ZOSTER OPHTHALMICUS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERMEDIATE UVEITIS; IRIDOCYCLITIS; KAPOSI SARCOMA; KERATOCONJUNCTIVITIS; KERATOCONJUNCTIVITIS SICCA; KERATOPATHY; KIDNEY FAILURE; KIRISAWA UVEITIS; MOLLUSCUM CONTAGIOSUM; MUSCLE HYPOTONIA; NEUTROPENIA; OPHTHALMOPLEGIA; OPPORTUNISTIC INFECTION; OPTIC NERVE DISEASE; PAPILLEDEMA; PNEUMOCYSTOSIS; PROSTHESIS FAILURE; RETINA DETACHMENT; RETINA MACULA CYSTOID EDEMA; RETINA MACULA EDEMA; RETINA MACULOPATHY; RETINA VASCULITIS; RETINITIS; REVIEW; TOXOPLASMOSIS; UVEITIS; VISUAL FIELD DEFECT; VITREOUS HEMORRHAGE; VITREOUS OPACITY; AIDS RELATED COMPLEX; CD4+ T LYMPHOCYTE; DEVELOPING COUNTRY; HEALTH; IMMUNOLOGY;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; DEVELOPING COUNTRIES; EYE INFECTIONS; HIV INFECTIONS; HUMANS; UVEITIS; WORLD HEALTH;

EID: 23044473812     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/j.1442-9071.2005.01001.x     Document Type: Review

References (175)

1. CDC. Pneumocystic pneumonia - Los Angeles. MMWR Recomm Rep 1981; 30: 250-2.
2. Joint United Nations Programme on HIV/AIDS. Report on the Global HIV/AIDS Epidemic 2002. Geneva: UNAIDS, 2002.Available from: http://www.unaids.org
3. Kestelyn PG, Cunningham ET Jr. HIV/AIDS and blindness. Bull World Health Organ 2001; 79: 208-13.
4. Havlir DV, Lange JM. New antiretrovirals and new combinations. AIDS 1998; 12: S165-74.
5. Pallela FJ, Delaney KM, Moorman AC et al. Declining morbidity and mortality among patients with advanced immunodeficiency virus infection. N Eng J Med 1998; 338: 853-60.
6. Jabs DA, Quinn TC. Acquired immunodeficiency syndrome. In: Pepose JS, Holland GN, Wilhelmus KR, eds. Ocular Infection and Immunity. St Louis: Mosby-Year Book, 1996; 289-310.
7. Buchbinder SP, Katz MH, Hessol NA et al. Herpes zoster and human immunodeficiency virus infection. J Inject Dis 1992; 116: 1153-6.
8. Glesby MJ, Moore RD, Chaisson RE. Herpes zoster in patients with advanced human immunodeficiency virus infection treated with zidovudine. Zidovudine Epidemiology Study Group. J Inject Dis 1993; 168: 1264-8.
9. Umeh RE. Herpes zoster ophthalmicus and HIV infection in Nigeria. Int J STD AIDS 1998; 9: 476-9.
10. Martinez E, Gatell J, Moran Y et al. High incidence of herpes zoster in patients with AIDS soon after therapy with protease inhibitors. Clin Infect Dis 1998; 27: 1510-13.
11. Selliti TP, Huang AJ, Schiffman J, Davis JL. Association of herpes zoster ophthalmicus with acquired immunodeficiency syndrome and acute retinal necrosis. Am J Ophthalmol 1993; 116: 297-301.
12. Meenken C, van der Horn GJ, de Smet MD, van der Meer JT. Optic neuritis heralding varicella zoster retinitis in a patient with acquired immunodeficiency syndrome. Ann Neurol 1998; 43: 534-6.
13. Lee MS, Cooney EI, Stoessel KM, Gariano RF. Varicella zoster virus retrobulbar optic neuritis preceding retinitis in patients with acquired immune deficiency syndrome. Ophthalmology 1998; 105: 467-71.
14. Tschachler E, Bergstresser PR, Stingl G. HIV-related skin diseases, Lancet 1996; 348: 659-63.
15. Dugel PU, Gill PS, Frangieh GT, Rao NA. Ocular adnexal Kaposi's sarcoma in acquired immunodeficiency syndrome. Am J Ophthalmol 1990; 110: 500-3.
16. Li JJ, Huang YQ, Cockerell CJ, Friedman-Kien AE. Localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of Kaposi's sarcoma lesions by in situ hybridization. Am J Pathol 1996; 148: 1741-8.
17. Cattelan AM, Calabro ML, Aversa SM et al. Regression of AIDS-related Kaposi's sarcoma following antiretroviral therapy with protease inhibitors: biological correlates of clinical outcome. Eur J Cancer 1999; 35: 1809-15.
18. Bower M, Fox P, Fife K, Gill J, Nelson M, Gazzard B. Highly active antiretroviral therapy (HAART) prolongs time to treatment failure in Kaposi's sarcoma. AIDS 1999; 13: 2105-11.
19. Grulich AE, Li Y, McDonald AM, Correll PK, Law MG, Kaldor JM. Decreasing rate of Kaposi's sarcoma and non-Hodgkin's lymphoma in the era of potent combination antiretroviral therapy. AIDS 2001; 15: 629-33.
20. Bardenstein DS, Elmets C. Hyperfocal cryotherapy of multiple Molluscum contagiosum lesions in patients with the acquired immune deficiency syndrome. Ophthalmology 1995; 102: 1031-4.
21. Robinson MR, Udell IJ, Garber PF, Perry HD, Streeten BW. Molluscum contagiosum of the eyelids in patients with acquired immune deficiency syndrome. Ophthalmology 1992; 99: 1754-7.
22. Albini T, Rao N. Molluscum contagiosum in an immune reconstituted AIDS patient. Br J Ophthalmol 2003; 87: 1427-8.
23. Hurni MA, Bohlen L, Furrer H, Braathen LR. Complete regression of giant molluscum contagiosum lesion in an HIV-infected patient following combined antiretroviral therapy with saquinavir, zidovudine and lamivudine. AIDS 1997; 11: 1784-5.
24. Akduman L, Pepose JS. Anterior segment manifestations of acquired immunodeficiency syndrome. Sermin Ophthalmol 1995; 10: 111-18.
25. Westcott MC, Ward M, Mitchell SM. Failure of accommodation in patients with HIV infection. Eye 2001; 15: 474-8.
26. Lucca JA, Farris RL, Bielory L, Caputo AR. Keratoconjunctivitis sicca in male patients infected with human immunodeficiency virus type 1. Ophthalmology 1990; 97: 1008-10.
27. Kordossis T, Paikos S, Aroni K et al. Prevalence of Sjogren-like syndrome in a cohort of HIV-1 positive patients: descriptive pathology and immunopathology. Br J Rheumatol 1998; 37: 691-5.
28. Panayiotakopoulos GD, Aroni K, Kyriaki D et al. Paucity of Sjogren-like syndrome in a cohort of HIV-1-positive patients in the HAART era. Part II. Rheumatology 2003; 42: 1164-7.
29. Young TL, Robin JB, Holland GN et al. Herpes simplex keratitis in patients with acquired immune deficiency syndrome. Ophthalmology 1989; 96: 1476-9.
30. Hodge WG, Margolis TP. Herpes simplex keratitis among patients who are positive or negative for human immunodeficiency virus: an epidemiologic study. Ophthalmology 1997; 104: 120-4.
31. Pramod NP, Hari R, Sudhamathi K, Ananadakannan K, Thyagarajan SP. Influence of human immunodeficiency virus status on the clinical history of herpes simplex keratitis. Ophthalmologica 2000; 214: 337-40.
32. Mselle J. Fungal keratitis as an indicator of HIV infection in Africa. Trop Doct 1999; 29: 133-5.
33. Weber R, Bryan RT, Schwartz DA, Owen RL. Human microsporidial infections. Clin Microbiol Rev 1994; 7: 429-61.
34. Lowder CY, McMahon JT, Meisler DM et al. Microsporidial keratoconjunctivitis caused by Septata intestinalis in a patient with acquired immunodeficiency syndrome. Am J Ophthalmol 1996; 121: 715-17.
35. Martins SA, Muccioli C, Belfort R, Castelo A. Resolution of microsporidial keratoconjunctivitis in an AIDS patient treated with highly active antiretroviral therapy. Am J Ophthalmol 2001; 131: 378-9.
36. Gajdatsy AD, Tay-Kearney ML. Microsporidial keratoconjunctivitis after HAART. Clin Experiment Ophthalmol 2001; 29: 327-9.
37. Verma S, Hughes JD, Mabey D, Graham EM. Symptomatic anterior uveitis in HIV-positive patients. Int J STD AIDS 1999; 10: 268-74.
38. Shalaby IA, Dunn JP, Semba RD, Jabs DA. Syphilitic uveitis in human immunodeficiency virus-infected patients. Arch Ophthalmol 1997; 115: 469-73.
39. Browning DJ. Posterior segment manifestations of active ocular syphilis, their response to a neurosyphilis regimen of penicillin therapy, and the influence of human immunodeficiency virus status on response. Ophthalmology 2001; 107: 2015-23.
40. Levy JH, Liss RA, Maguire AM. Neurosyphilis and ocular syphilis in patients with concurrent human immunodeficiency virus infection. Retina 1989; 9: 175-80.
41. Rivero ME, Kupperman BD, Wiley CA. Acquired immunodeficiency syndrome-related intraocular B-cell lymphoma. Arch Ophthalmol 1999; 117: 616-22.
42. Rosberger DF, Heinemann MH, Friedberg DN, Holland GN. Uveitis associated with human immunodeficiency virus infection. Am J Ophthalmol 1998; 125: 301-5.
43. Cochereau I, Doan S, Guvenisik N et al. Epidemiological considerations about retinal opportunistic infections in HIV-infected patients in France. Ocul Immunol Inflamm 1999; 7: 167-71.
44. Hutchinson S, Courtney R, Mulcahy F, O'Connor M, Mullaney S, Kilbride R. Monitoring cytomegalovirus retinitis prevalence in an HIV-seropositive cohort: the assessment of improvements observed following the introduction of highly active antiretroviral triple therapy. Int J STD AIDS 1999; 10: 652-6.
45. Deayton JR, Wilson P, Sabin C et al. Changes in the natural history of cytomegalovirus retinitis following the introduction of highly active antiretroviral therapy. AIDS 2000; 14: 1163-70.
46. Kempen JH, Martin BK, Wu AW, Barron B, Thorne JE, Jabs DA. The effect of cytomegalovirus retinitis on the quality of life of patients with AIDS in the era of highly active antiretroviral therapy. Ophthalmology 2003; 110: 987-95.
47. Kempen JH, Jabs DA, Wilson LA, Dunn JP, West SK, Tonascia JA. Risk of visual loss in patients with cytomegalovirus retinitis and the acquired immunodeficiency syndrome. Arch Ophthalmol 2003; 121: 466-76.
48. Holbrook JT, Jabs DA, Weinberg DV, Lewis RA, Davis MD, Friedberg D. Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy. Arch Ophthalmol 2003; 121: 99-107.
49. Kempen JH, Jabs DA, Dunn JP, West SK, Tonascia J. Retinal detachment risk in cytomegalovirus retinitis related to the acquired immunodeficiency syndrome. Arch Ophthalmol 2001; 119: 33-40.
50. Martin DF, Dunn JP, Davis JL et al. Use of the ganciclovir implant for the treatment of cytomegalovirus retinitis is the era of potent antiretroviral therapy: recommendations of the International AIDS Society - USA Panel. Am J Ophthalmol 1999; 127: 329-39.
51. Martin DF, Kuppermann BD, Wolitz RA, Palestine AG, Li H, Robinson CA. Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group. N Eng J Med 1999; 340: 1063-70.
52. Perry CM, Balfour JA. Fomirvirsen. Drugs 1999; 57: 375-81.
53. Lalezari JP, Stagg RJ, Kupperman BD et al. Intravenous cidofovir for peripheral cytomegalovirus retinitis in patients with AIDS. A randomized, controlled trial. Ann Intern Med 1997; 126: 257-63.
54. The Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis. N Eng J Med 1992; 326: 213-20.
55. Imai Y, Shum C, Martin DF, Kuppermann BD, Drew WL, Margolis TP. Emergence of drug-resistant cytomegalovirus retinitis in the contralateral eyes of patients with AIDS treated with ganciclovir. J Infect Dis 2004; 189: 611-15.
56. Mahadevia PJ, Gebo KA, Pettit K, Dunn JP, Covington MT. The epidemiology, treatment patterns, and costs of cytomegalovirus retinitis in the post-HAART era among a national managed-care population. J Acquir Immune Defic Syndr 2004; 36: 972-7.
57. Young S, McCluskey P, Minassian DC et al. Retinal detachment in cytomegalovirus retinitis: intravenous versus intravitreal therapy. Clin Experiment Ophthalmol 2003; 31: 96-102.
58. Musch DC, Martin DF, Gordon JF et al. Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. N Eng J Med 1997; 337: 83-90.
59. McCluskey PJ, Shah R, Versace P. Outcomes of cytomegalovirus retinitis following the use of ganciclovir implants. Aust NZ J Ophthalmol 1998; 26: 207-10.
60. Roth DB, Feuer WJ, Blenke AJ, Davis JL. Treatment of recurrent cytomegalovirus retinitis with the ganciclovir implant. Am J Ophthalmol 1999; 127: 276-82.
61. The Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. Combination foscarnet and ganciclovir therapy vs. monotherapy for the treatment of relapsed cytomegalovirus retinitis in patients with AIDS. The Cytomegalovirus Retreatment Trial. Arch Ophthalmol 1996; 114: 23-33.
62. Vitravene Study Group. Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS. Am J Ophthalmol 2002; 133: 475-83.
63. Tural C, Romeu J, Sierra G et al. Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus-infected patients. J Infect Dis 1998; 177: 1080-3.
64. MacDonald JC, Torriani FJ, Morse LS, Karavellas MP, Reed JB, Freeman WR. Lack of reactivation of cytomegalovirus (CMV) retinitis after stopping CMV maintenance therapy in AIDS patients with sustained elevations in CD4 T cells in response to highly active antiretroviral therapy. J Infect Dis 1998; 177: 1182-7.
65. Jouan M, Saves M, Tubiana R et al. Discontinuation of maintenance therapy for cytomegalovirus retinitis in HIV-infected patients receiving highly active antiretroviral therapy. AIDS 2001; 15: 23-31.
66. Song MK, Karavellas MP, MacDonald JC, Plummer DJ, Freeman WR. Characterization of reactivation of cytomegalovirus retinitis patients healed after treatment with highly active antiretroviral therapy. Retina 2000; 20: 151-5.
67. Michelet C, Arvieux C, Francois C et al. Opportunistic infections occurring during highly active antiretroviral treatment. AIDS 1998; 12: 1815-22.
68. Whitcup SM. Cytomegalovirus retinitis in the era of highly active antiretroviral therapy. JAMA 2000; 283: 653-7.
69. Jacobson MA, Zegans M, Pavan PR et al. Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy. Lancet 1997; 349: 1443-5.
70. Petit N, Zandotti C, Riss JM, Frippiat F, Moulin JF, Gastaut JA. Relapse of CMV retinitis in an AIDS patient with high CD4 counts. J Antimicrob Chemother 1998; 41: 666-7.
71. Dunn JP. Discontinuation of maintenance CMV therapy in HAART responders. Hopkins HIV Rep 1999; 11: 5.
72. Nguyen QD, Kempen JH, Bolton SG, Dunn JP, Jabs DA. Immune recovery uveitis in patients with AIDS and Cytomegalovirus retinitis after highly active antiretroviral therapy. Am J Ophthalmol 2000; 129: 634-9.
73. Karavellas MP, Azen SP, MacDonald JC et al. Immune recovery vitritis and uveitis in AIDS: clinical predictors, sequelae, and treatment outcomes. Retina 2001; 21: 1-9.
74. Arevalo JF, Mendoza AJ, Ferreti Y. Immune recovery uveitis in AIDS patients with cytomegalovirus retinitis treated with highly active antiretroviral therapy in Venezuela. Retina 2003; 23: 495-502.
75. Karavellas MP, Lowder CY, MacDonald JC, Avila CP, Freeman WR. Immune recovery vitritis in patients with inactive cytomegalovirus retinitis: a new syndrome. Arch Ophthalmol 1998; 116: 169-75.
76. Silverstein BE, Smith JH, Sykes SO, Jones MR, Schwartz D, Cunningham ET Jr. Cystoid macular edema associated with Cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Am J Ophthalmol 1998; 125: 412-15.
77. Weinberg DV, Moorthy RS. Cystoid macular oedema due to Cytomegalovirus retinitis in a patient with acquired immunodeficiency syndrome. Retina 1996; 16: 343-4.
78. Gross JG, Bozzette SA, Matthews WC et al. Longitudinal study of Cytomegalovirus retinitis in acquired immune deficiency syndrome. Ophthalmology 1990; 97: 681-6.
79. Palestine AG, Frishberg B. Macular edema in acquired immunodeficiency syndrome-related microvasculopathy. Am J Ophthalmol 1991; 111: 770-1.
80. Robinson MR, Reed G, Csaky KG, Polis MA, Whitcup SM. Immune-recovery uveitis in patients with Cytomegalovirus retinitis taking highly active antiretroviral therapy. Am J Ophthalmol 2000; 130: 49-56.
81. Markomichelakis NN, Halkiadakis I, Pantelia E et al. Patterns of macular edema in patients with uveitis: qualitative and quantitative assessment using optical coherence tomography. Ophthalmology 2004; 111: 946-53.
82. Bartsch DG, Aurora A, Rodanant N, Cheng L, Freeman WR. Volumetric analysis of macular edema by scanning laser tomography in immune recovery uveitis. Arch Ophthalmol 2003; 121: 1246-51.
83. Goldberg DE, Freeman WR. Uveitic angle closure glaucoma in a patient with inactive cytomegalovirus retinitis and immune recovery uveitis. Ophthalmic Surg Lasers 2002; 33: 421-5.
84. Postelmans L, Payen MC, De Wit S, Caspers-Velu L. Neovascularization of the optic disc after highly active antiretroviral therapy in an AIDS patient with cytomegalovirus retinitis - a new immune recovery-related ocular disorder? Ocul Immunol Inflamm 1999; 7: 237-40.
85. Song MK, Azen SP, Buley A et al. Effect of anti-cytomegalovirus therapy on the incidence of immune recovery uveitis in AIDS patients with healed cytomegalovirus retinitis. Am J Ophthalmol 2003; 136: 696-702.
86. Henderson H, Mitchell S. Treatment of immune recovery uveitis with local steroids. Er J Ophthalmol 1999; 83: 540-5.
87. Kosobucki BR, Goldberg DE, Bessho K et al. Valganciclovir therapy for immune recovery uveitis complicated by macular edema. Am J Ophthalmol 2004; 137: 636-8.
88. Zegans ME, Walton RC, Holland GN, O'Donnell JR, Jacobson MA, Margolis TP. Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis. Am J Ophthalmol 1998; 125: 292-30.
89. Magone MT, Nussenblatt RB, Whitcup SM. Elevation of laser flare photometry in patients with cytomegalovirus and AIDS. Am J Ophthalmol 1997; 124: 190-8.
90. Karavellas MP, Plummer DJ, Macdonald JC et al. Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of highly active antiretroviral therapy. J Inject Dis 1999; 179: 697-700.
91. McCune JM, Hanley MB, Cesar D et al. Factors influencing T-cell turnover in HIV-1-seropositive patients. J Clin Invest 2000; 105: R1-8.
92. Mutimer HP, Akatsuka Y, Manley T et al. Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response. J Infect Dis 2002; 186: 701-5.
93. Zamir E, Hudson H, Ober RR et al. Massive mycobacterial choroiditis during highly active antiretroviral therapy: another immune-recovery uveitis. Ophthalmology 2002; 109: 2144-8.
94. Race EM, Adelson-Mitty J, Kriegel GR et al. Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease. Lancet 1998; 351: 252-5.
95. Peyman GA, Morton FG, Uninsky E, Tessler H, Pulido J, Hendricks R. Vitrectomy and intravitreal antiviral drug therapy in acute retinal necrosis syndrome. Arch Ophthalmol 1984; 102: 1618-21.
96. Jabs DA, Schachat AP, Liss R, Knox DL, Michels RG. Presumed varicella zoster retinitis in immunocompromised patients. Retina 1987; 7: 9-13.
97. Batisse D, Eliaszewicz M, Zazoun L, Baudrimont Pialoux G, Dup B. Acute retinal necrosis in the course of AIDS: study of 26 cases. AIDS 1996; 10: 1300-1.
98. Holland GN. Standard diagnostic criteria for acute retinal necrosis syndrome. Am J Ophthalmol 1994; 117: 663-7.
99. Duker JS, Nielsen JC, Eagle RC, Bosley TM, Granadier R, Benson WE. Rapidly progressive acute retinal necrosis secondary to herpes simplex virus, type 1. Ophthalmology 1990; 97: 1638-43.
100. Margolis T, Irvine AR, Hoyt WF, Hyman R. Acute retinal necrosis syndrome presenting with papillitis and arcuate neuroretinitis. Ophthalmology 1988; 95: 937-40.
101. Nogueira ML, Siquera RC, Freitas N et al. Detection of herpesvirus DNA by the polymerase chain reaction (PCR) in vitreous samples from patients with necrotizing retinitis. J Clin Pathol 2001; 54: 103-6.
102. Short GA, Margolis TP, Kepperman BD, Irvine AR, Martin DF, Chandler D. A polymerase chain reaction-based assay for diagnosing varicella-zoster virus retinitis in patients with acquired immunodeficiency syndrome. Am J Ophthalmol 1997; 123: 157-64.
103. Palay DA, Sternberg P, Davis J et al. Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy. Am J Ophthalmol 1991; 112: 250-5.
104. Luu KK, Scott IU, Chaudhry NA, Verm A, Davis JL. Intravitreal antiviral injections as adjunctive therapy in the management of immunocompetent patients with necrotizing herpetic retinopathy. Am J Ophthalmol 2000; 129: 811-13.
105. Tran TH, Stanescu D, Caspers-Velu L et al. Clinical characteristics of acute HSV-2 retinal necrosis. Am J Ophthalmol 2004; 137: 872-9.
106. Chau Tran TH, Cassoux N, Bodaghi B, Lehoang P. Successful treatment with combination of systemic antiviral drugs and intravitreal ganciclovir injections in the management of severe necrotizing herpetic retinitis. Ocul Immunol Inflamm 2003; 11: 141-4.
107. Zambarakji HJ, Obi AA, Mitchell SM. Successful treatment of varicella zoster virus retinitis with aggressive intravitreal and systemic antiviral therapy. Ocul Immunol Inflamm 2002; 10: 41-6.
108. Culbertson WW, Clarkson JG, Blumenkranz M, Lewis ML. Acute retinal necrosis. Am J Ophthalmol 1983; 96: 683-5.
109. Culbertson WW, Atherton SS. Acute retinal necrosis and similar retinitis syndromes. Int Ophthalmol Clin 1993; 33: 129-43.
110. Ando F, Kato M, Goto S, Kobayashi K, Ichikawa H, Kamiya T. Platelet function in bilateral acute retinal necrosis. Am J Ophthalmol 1983; 96: 27-32.
111. Sternberg P, Han DP, Yeo JH et al. Photocoagulation to prevent retinal detachment in acute retinal necrosis. Ophthalmology 1988; 95: 1389-93.
112. Clarkson JG, Blumenkranz MS, Culbertson WW, Flynn HW, Lewis ML. Retinal detachment following the acute retinal necrosis syndrome. Ophthalmology 1984; 91: 1665-8.
113. Blumenkranz M, Clarkson J, Culbertson WW, Flynn HW, Lewis ML, Young GA. Vitrectomy for retinal detachment associated with acute retinal necrosis. Am J Ophthalmol 1988; 106: 426-9.
114. Engstrom RE, Holland GN, Margolis TP et al. The progressive outer retinal necrosis syndrome. A variant to necrotizing herpetic retinopathy in patients with AIDS. Ophthalmology 1994; 101: 1488-502.
115. Omerod LD, Larkin JA, Margo CA et al. Rapidly progressive herpetic retinal necrosis: a blinding disease characteristics of advanced AIDS. Clin Infect Dis 1998; 26: 34-45.
116. Kashiwase M, Sata T, Yamauchi Y et al. Progressive outer retinal necrosis caused by herpes simplex virus type 1 in a patient with acquired immunodeficiency syndrome. Ophthalmology 2000; 107: 790-4.
117. Moorthy RS, Weinberg DV, Teich SA et al. Management of varicella zoster virus retinitis in AIDS. Br J Ophthalmol 1997; 81: 189-94.
118. Perez-Blazquez E, Traspas R, Mendez Marin I, Montera M. Intravitreal ganciclovir treatment in progressive outer retinal necrosis. Am J Ophthalmol 1997; 124: 418-21.
119. Scott IU, Luu KM, Davis JL. Intravitreal antivirals in the management of patients with acquired immunodeficiency syndrome with progressive outer retinal necrosis. Arch Ophthalmol 2002; 120: 1219-22.
120. Roig-Melo EA, Macky TA, Heredia-Elizondo ML, Alfaro DV III. Progressive outer retinal necrosis syndrome: successful treatment with a new combination of antiviral drugs. Eur J Ophthalmol 2001; 11: 200-2.
121. Bouza E, Merino P, Munoz P, Sanchez-Carrillo C, Yanez J, Cortes C. Ocular tuberculosis. A prospective study in a general hospital. Medicine (Baltimore) 1997; 76: 53-61.
122. Sheu SJ, ShyuJS, Chen LM, Chen YY, Chirn SC, Wang JS. Ophthalmology 2001; 108: 1580-5.
123. Rodgers CA, Harris JR. Ocular toxoplasmosis in HIV infection. Int J STD AIDS 1996; 7: 307-9.
124. Cochereau-Massin I, LeHoang P, Lautier-Frau M et al. Ocular toxoplasmosis in human immunodeficiency virus-infected patients. Am J Ophthalmol 1992; 114: 130-5.
125. Damms T, Bohnke M, Behrend-Berdin B. Results of therapy in ocular toxoplasmosis. Comparison of various forms of therapy. Ophthalmologe 1993; 90: 737-41.
126. Morinelli EN, Dugel PU, Riffenburgh R, Rao NA. Infectious multifocal choroiditis in patients with acquired immunodeficiency syndrome. Ophthalmology 1993; 100: 1014-21.
127. Freeman WR, Chen A, Henderly DE et al. Prevalence and significance of acquired immunodeficiency syndrome-related retinal microvasculopathy. Am J Ophthalmol 1989; 107: 229-35.
128. Glasgow BJ, Weisberger AK. A quantitative and cartographic study of retinal microvasculopathy in acquired immunodeficiency syndrome. Am J Ophthalmol 1994; 118: 45-56.
129. Nussenblatt RB, Lane HC. Human immunodeficiency virus disease: changing patterns of intraocular inflammation. Am J Ophthalmol 1998; 125: 374-82.
130. Lim MC, Cumberland WG, Minassian SL et al. Decreased macular leukocyte velocity in human immunodeficiency virus-infected individuals. Am J Ophthalmol 2001; 132: 711-19.
131. Golderberg DT, Holland GN, Cumberland WG et al. An assessment of polymorphonuclear leukocyte rigidity in HIV-infected individuals after immune recovery. Invest Ophthalmol Vis Sci 2002; 43: 1857-61.
132. Mansour AM. Neuro-ophthalmic findings in acquired immunodeficiency syndrome. J Clin Neuro-ophthal 1990; 10: 167-74.
133. Friedman DI. Neuro-ophthalmic manifestations of human immunodeficiency virus infection. Neurol Clin 1991; 9: 55-72.
134. Omerod LD, Rhodes RH, Gross SA, Crane LR, Houchin KW. Ophthalmologic manifestations of acquired immunodeficiency syndrome-associated progressive multifocal leukoencephalopathy. Ophthalmology 1996; 103: 899-906.
135. Wein F, Francis GS, Gans MS, Connolly WE, Burnier MN Jr. Neuro-ophthalmic findings in progressive multifocal leukoencephalopathy. Can J Ophthalmol 1998; 33: 270-5.
136. Gray F, Chretien F, Vallat-Decouvelaere AV, Scaravilli F. The changing pattern of HIV neuropathology in the HAART era. J Neuropathol Exp Neurol 2003; 62: 429-40.
137. Shah GK, Cantrill HL, Holland EJ. Vortex keratopathy associated with atovaquone. Am J Ophthalmol 1995; 120: 669-71.
138. Davis JL, Taskintuna I, Freeman WR, Weinberg DV, Feuer WJ, Leonard RE. Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. Arch Ophthalmol 1997; 115: 785-6.
139. Ambati J, Wynne KB, Angerame MC, Robinson MR. Anterior uveitis associated with intravenous cidofovir use in patients with cytomegalovirus retinitis. Br J Ophthalmol 2000; 84: 233-5.
140. Akler ME, Johnson DW, Burman WJ, Johnson SC. Anterior uveitis and hypotony after intravenous cidofovir for the treatment of cytomegalovirus retinitis. Ophthalmology 1998; 105: 651-7.
141. Bainbridge JW, Raina J, Shah SM, Ainsworth J, Pinching AJ. Ocular complications of intravenous cidofovir for cytomegalovirus retinitis in patients with AIDS. Eye 1999; 13: 353-6.
142. Taskintuna I, Rahhal FM, Arevalo JF et al. Low-dose intravitreal cidofovir (HPMPC) therapy of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. Ophthalmology 1997; 104: 1049-57.
143. Rahhal FM, Arevalo JF, Munguia D et al. Intravitreal cidofovir for the maintenance treatment of cytomegalovirus retinitis. Ophthalmology 1996; 103: 1078-83.
144. de Semet MD, Meenken C, van den Horn GJ. Fomivirsen: a phosphothioate oligonucleotide for the treatment of. CMV Retinitis 1999; 57: 375-80.
145. Hudson HL, Boyer DS, Kupperman BD. Future trends and experimental modalities in the therapeutics of cytomegalovirus retinitis. Ophthalmol Clin North Am 1997; 10: 61-71.
146. Amin HI, Ai E, McDonald HR, Johnson RN. Retinal toxic effects associated with intravitreal fomivirsen. Arch Ophthalmol 2000; 118: 426-7.
147. Stone TW, Jaffe GJ. Reversible bull's-eye maculopathy associated with intravitreal fomivirsen therapy for cytomegalovirus retinitis. Am J Ophthalmol 2000; 103: 242-3.
148. Guembel HO, Krieglsteiner S, Rosenkranz C, Hattenbach LO, Koch FM, Ohrloff C. Complications after implantation of intraocular devices in patient with cytomegalovirus retinitis. Graefes Arch Clin Exp Ophthalmol 1999; 237: 824-9.
149. Taguri AH, Dhillon B, Wharton SB, Kamal A. Foreign body reaction with delayed extrusion of ganciclovir implant in a patient with immune recovery vitritis syndrome. Am J Ophthalmol 2002; 133: 147-9.
150. Saran BR, Maguire AM, Nichols C et al. Hypopyon uveitis in patients with acquired immunodeficiency syndrome treated for systemic Mycobactenum avium complex infection with rifabutin. Arch Ophthalmol 1994; 112: 1159-65.
151. Jacobs DS, Piliero PJ, Kuperwaser MG et al. Acute uveitis associated with rifabutin use in patients with human immunodeficiency virus infection. Am J Ophthalmol 1994; 118: 716-22.
152. Chaknis MJ, Brooks SE, Mitchell KT, Marcus DM. Inflammatory opacities of the vitreous in rifabutin-associated uveitis. Am J Ophthalmol 1996; 122: 580-2.
153. Smith JA, Mueller BU, Nussenblatt RB, Whitcup SM. Corneal endothelial deposits in children positive for human inmmunodeficiency virus receiving rifabutin prophylaxis for Mycobacterium avium complex bacteremia. Am J Ophthalmol 1999; 127: 164-9.
154. Vaudaux JD, Guex-Crosier Y. Rifabutin-induced cystoid macular oedema. J Antimicrob Chemother 2002; 49: 421-2.
155. Arevalo JF, Russack V, Freeman WR. New ophthalmic manifestations of presumed rifabutin-related uveitis. Ophthalmic Surglasers 1997; 28: 321-4.
156. Shafran SD, Singer J, Zarowny DP et al. A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin versus rifampin, ethambutol, clofazimine, and ciprofloxacin. Canadian HIV Trials Network Protocol 010 Study Group. N Engl J Med 1996; 335: 377-83.
157. Nichols CW. Mycobacterium avium complex infection, rifabutin, and uveitis - is there a connection? Clin Infect Dis 1996; 22: S43-7.
158. Cochereau I, Mlika-Cabanne N, Godinaud P et al. AIDS related eye disease in Burundi, Africa. Br J Ophthalmol 1999; 83: 339-42.
159. Kestelyn P. The epidemiology of CMV retinitis in Africa. Ocul Immunol Inflamm 1999; 7: 173-7.
160. Lewallen S, Courtright P. HIV and AIDS and the eye in developing countries. Arch Ophthalmol 1997; 115: 1291-5.
161. Van de Perre P, Bakkers E, Batungvanao J et al. Herpes zoster in African patients: an early manifestations of HIV infection. Scand J Infect Dis 1988; 20: 277-82.
162. Kestelyn P, Stevens AM, Bakkers E, Rouvroy D, Van de Perre P. Severe herpes zoster ophthalmicus in young African patients: a marker for HTLV-III seropositivity. Br J Ophthalmol 1987; 71: 806-9.
163. Lewallen S. Herpes zoster ophthalmicus in Malawi. Ophthalmology 1994; 101: 1801-4.
164. Ateenyi-Agaba C. Conjunctival squamous cell carcinoma associated with HIV infection in Kampala, Uganda. Lancet 1995; 345: 695-6.
165. Mahomed A, Chetty R. Human immunodeficiency virus infection, Bcl-2. p53 protein and Ki-67 analysis in ocular surface squamous neoplasia. Arch Ophthalmol 2002; 120: 554-8.
166. Lewallen S, Kumwenda J, Maher D, Harries AD. Retinal findings in Malawian patients with AIDS. Br J Ophthalmol 1994; 78: 757-9.
167. Jaffar S, Ariyoshi K, Frith P. Retinal manifestations of HIV-1 and HIV-2 infections among hospital patients in the Gambia, west Africa. Trop Med Int Health 1999; 4: 487-92.
168. Biswas J, Madhavan HN, George AE, Kumarasamy N, Solomon S. Ocular lesions associated with HIV infection in India: a series of 100 consecutive patients evaluated at a referral center. Am J Ophthalmol 2000; 129: 9-15.
169. Mwanza JC, Kayember DL. Uveitis in HIV-infected patients. Eur J Ophthalmol 2001; 11: 53-6.
170. Swinne D, Deppner M, Laroche R, Floch FF, Kadende P. Isolation of Cryptococcus neoformans from houses of AIDS-associated Cryptococcosis patients in Bujumbura (Burundi). AIDS 1989; 3: 389-90.
171. Satishchandra P, Nalini A, Gourie-Devi M et al. Profile of neurologic disorders associated with HIV/AIDS from Bangalore, South India (1989-96). Indian J Med Res 2000; 111: 23.
172. Dennehy PJ, Warman R, Flynn JT, Scott GB, Mastrucci MT. Ocular manifestations in pediatric patients with acquired immunodeficiency syndrome. Arch Ophthalmol 1989; 107: 978-82.
173. Biswas J, Kumar AA, George AE et al. Ocular and systemic lesions in children with HIV. Indian J Pediatr 2000; 67: 721-4.
174. Padhani DH, Manji KP, Mtanda AT. Ocular manifestations in children with HIV infection in Dar es Salaam, Tanzania. J Trop Pediatr 2000; 46: 145-8.
175. Kestelyn P, Lepage P, Karita E, Van de Perre P. Ocular manifestations of infection with the human immunodeficiency virus in an African pediatric population. Ocul Immunol Inflamm 2000; 8: 263-73.