Emergence of Drug-Resistant Cytomegalovirus Retinitis in the Contralateral Eyes of Patients with AIDS Treated with Ganciclovir

Journal of Infectious Diseases

Volumn 189, Issue 4, 2004, Pages 611-615

  Imai, Yumi ^a   Shum, Carol ^a   Martin, Daniel F ^c   Kuppermann, Baruch D ^b   Drew, W Lawrence ^a   Margolis, Todd P ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; VIRUS DNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CLINICAL TRIAL; CODON; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG IMPLANT; EYE INFECTION; GENE MUTATION; GENOTYPE; HUMAN; HUMAN TISSUE; INFECTION RATE; INFECTION RISK; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINITIS; SEROPREVALENCE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADMINISTRATION, ORAL; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS RETINITIS; DNA, VIRAL; DRUG IMPLANTS; DRUG RESISTANCE, VIRAL; FUNCTIONAL LATERALITY; GANCICLOVIR; HUMANS; INJECTIONS, INTRAVENOUS; MUTATION; PLACEBOS;

EID: 1442325329     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/381394     Document Type: Article

References (20)

1. Cytomegalovirus retinitis. In: Forrester JV, Okada AA, BenEzra D, Ohno S, eds. Posterior segment intraocular inflammation: guidelines. The Hague: Kugler Publications, 1998:66-70.
2. Holland GN. Acquired immunodeficiency syndrome and ophthalmology: the first decade. Am J Ophthalmol 1992; 114:86-95.
3. Drew WL, Stempien MJ, Andrews J, et al. Cytomegalovirus (CMV) resistance in patients with CMV retinitis and AIDS treated with oral or intravenous ganciclovir. J Infect Dis 1999; 179:1352-5.
4. Jabs DA, Enger C, Dunn JP, Forman M. Cytomegalovirus retinitis and viral resistance: ganciclovir resistance. CMV Retinitis and Viral Resistance Study Group. J Infect Dis 1998; 177:770-3.
5. Jabs DA, Dunn JP, Enger C, Forman M, Bressler N, Charache P. Cytomegalovirus retinitis and viral resistance: prevalence of resistance at diagnosis, 1994. Cytomegalovirus Retinitis and Viral Resistance Study Group. Arch Ophthalmol 1996; 114:809-14.
6. Drew WL, Miner RC, Busch DF, et al. Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection. J Infect Dis 1991; 163:716-9.
7. Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 1992; 358:162-4.
8. Littler E, Stuart AD, Chee MS. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Nature 1992; 358:160-2.
9. Chou S, Guentzel S, Michels KR, Miner RC, Drew WL. Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates. J Infect Dis 1995; 172:239-42.
10. Erice A, Gil-Roda C, Perez JL, et al. Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients. J Infect Dis 1997; 175: 1087-92.
11. Smith IL, Cherrington JM, Jiles RE, Fuller MD, Freeman WR, Spector SA. High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes. J Infect Dis 1997; 176:69-77.
12. Mar EC, Chiou JF, Cheng YC, Huang ES. Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2- propoxymethyl)guanine. J Virol 1985; 53:776-80.
13. Liu W, Kuppermann BD, Martin DF, Wolitz RA, Margolis TP. Mutations in the cytomegalovirus UL97 gene associated with ganciclovir-resistant retinitis. J Infect Dis 1998; 177:1176-81.
14. Kuo IC, Imai Y, Shum C, Martin DF, Kuppermann BD, Margolis TP. Genotypic analysis of CMV retinitis poorly responsive to intravenous ganciclovir but responsive to the ganciclovir implant. Am J Ophthalmol 2003; 135:20-5.
15. Collier AC, Chandler SH, Handsfield HH, Corey L, McDougall JK. Identification of multiple strains of cytomegalovirus in homosexual men. J Infect Dis 1989; 159:123-6.
16. Spector SA, Hirata KK, Newman TR. Identification of multiple cytomegalovirus strains in homosexual men with acquired immunodeficiency syndrome. J Infect Dis 1984; 150:953-6.
17. Liu W, Shum C, Martin DF, Kuppermann BD, Hall AJH, Margolis TP. Prevalence of antiviral drug resistance in untreated patients with cytomegalovirus retinitis. J Infect Dis 2000; 182:1234-8.
18. Hu H, Jabs DA, Forman MS, et al. Comparison of cytomegalovirus (CMV) UL97 gene sequences in the blood and vitreous of patients with acquired immunodeficiency syndrome and CMV retinitis. J Infect Dis 2002; 185:861-7.
19. Martin DF, Kuppermann BD, Wolitz RA, Palestine AG, Li H, Robinson CA. Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group. N Engl J Med 1999; 340:1063-70.
20. McCann JD, Margolis TP, Wong MG, et al. A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis. Am J Ophthalmol 1995; 120:219-26.