The chemopreventive agent resveratrol stimulates cyclic AMP - Dependent chloride secretion in vitro

Clinical Cancer Research

Volumn 11, Issue 15, 2005, Pages 5651-5656

  Blumenstein, Irina ^a   Keserü, Benjamin ^a   Wolter, Freya ^a   Stein, Jürgen ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; CHLORIDE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; OUABAIN; PICEATANNOL; POLYPHENOL; RESVERATROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER PREVENTION; CHLORIDE TRANSPORT; CONTROLLED STUDY; DIARRHEA; DOSE TIME EFFECT RELATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; JEJUNUM; MALE; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER;

ANIMALS; ANTICARCINOGENIC AGENTS; BUTYRATES; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHLORIDES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FORSKOLIN; HUMANS; JEJUNUM; MALE; MICE; MICE, INBRED BALB C; SIGNAL TRANSDUCTION; STILBENES; TIME FACTORS;

EID: 23044459637     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-2674     Document Type: Article

References (44)

1. Hain R, Bieseler B, Kindl H, Schroder G, Stocker R. Expression of a stilbene synthase gene in Nicotiana tabacum results in synthesis of the phytoalexin resveratrol. Plant Mol Biol 1990;15:325-35.
2. Schubert R, Fischer R, Hain R, et al. An ozone-responsive region of the grapevine resveratrol synthase promoter differs from the basal pathogen-responsive sequence. Plant Mol Biol 1997;34:417-26.
3. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
4. Wolter F, Ulrich S, Stein J. Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in colorectal cancer: key role of polyamines? J Nutr 2004;134:3219-22.
5. Ulrich S, Wolter F, Stein JM. Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis. Mol Nutr Food Res 2005;49:452-61.
6. Roman V, Billard C, Kern C, et al. Analysis of resveratrol-induced apoptosis in human B-cell chronic leukaemia. Br J Haematol 2002;117:842-51.
7. Kuo PL, Chiang LC, Lin CC. Resveratrol-induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells. Life Sci 2002;72:23-34.
8. Ferry-Dumazet H, Garnier O, Mamani-Matsuda M, et al. Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells. Carcinogenesis 2002;23:1327-33.
9. Fauconneau B, Waffo-Teguo P, Huguet F, Barrier L, Decendit A, Merillon JM. Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests. Life Sci 1997;61:2103-10.
10. Frankel EN, Waterhouse AL, Kinsella JE. Inhibition of human LDL oxidation by resveratrol. Lancet 1993;341:1103-4.
11. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
12. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
13. Kimura Y, Okuda H, Arichi S. Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim Biophys Acta 1985;834:275-8.
14. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Preclinical and clinical studies. Anticancer Res 2004;24:2783-840.
15. Dagher PC, Egnor RW, Taglietta-Kohlbrecher A, Charney AN. Short-chain fatty acids inhibit cAMP-mediated chloride secretion in rat colon. Am J Physiol 1996;271:C1853-60.
16. El Mowafy AM, White RE. Evidence for a tyrosine kinase-dependent activation of the adenylyl cyclase/PKA cascade downstream from the G-protein-linked endothelin ETA receptor in vascular smooth muscle. Biochem Biophys Res Commun 1998;251:494-500.
17. El Mowafy AM, Alkhalaf M. Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis 2003;24:869-73.
18. Binder HJ, Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 1989;96:989-96.
19. Bugaut M. Occurrence, absorption and metabolism of short chain fatty acids in the digestive tract of mammals. Comp Biochem Physiol B 1987;86:439-72.
20. Ramakrishna BS, Nance SH, Roberts-Thomson IC, Roediger WE. The effects of enterotoxins and short-chain fatty acids on water and electrolyte fluxes in ileal and colonic loops in vivo in the rat. Digestion 1990;45:93-101.
21. Resta-Lenert S, Truong F, Barrett KE, Eckmann L. Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity. Am J Physiol Cell Physiol 2001;281:0837-49.
22. Dharmsathaphorn K, McRoberts JA, Mandel KG, Tisdale LD, Masui H. A human colonic tumor cell line that maintains vectorial electrolyte transport. Am J Physiol 1984;246:G204-8.
23. Illek B, Lizarzaburu ME, Lee V, Nantz MH, Kurth MJ, Fischer H. Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. Am J Physiol Cell Physiol 2000;279:C1838-46.
24. Soleas GJ, Van J, Goldberg DM. Measurement of trans-resveratrol, (+)-catechin, and quercetin in rat and human blood and urine by gas chromatography with mass selective detection. Methods Enzymol 2001;335:130-45.
25. Fremont L, Gozzelino MT, Linard A. Response of plasma lipids to dietary cholesterol and wine polyphenols in rats fed polyunsaturated fat diets. Lipids 2000;35:991-9.
26. Illek B, Fischer H. Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vivo. Am J Physiol 1998;275:L902-10.
27. 84 cell monolayers. Am J Physiol 1995;269:G874-82.
28. Illek B, Fischer H, Machen TE. Alternate stimulation of apical CFTR by genistein in epithelia. Am J Physiol 1996;270:C265-75.
29. 84 colonic epithelial cell line with dietary flavonols. Biochem Pharmacol 1991;41:1879-86.
30. Kahn ME, Senderowicz A, Sausville EA, Barrett KE. Possible mechanisms of diarrheal side effects associated with the use of a novel chemotherapeutic agent, flavopiridol. Clin Cancer Res 2001;7:343-9.
31. Cermak R, Vujicic Z, Scharre E, Wolfram S. The impact of different flavonoid daises on colonic Cl- secretion in rats. Biochem Pharmacol 2001;62:1145-51.
32. Ko WH, Law VW, Yip WC, et al. Stimulation of chloride secretion by baicalein in isolated rat distal colon. Am J Physiol Gastrointest Liver Physiol 2002;282. G508-18.
33. Senderowicz AM. Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. Invest New Drugs 1999;17:313-20.
34. Senderowicz AM. Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies. Leukemia 2001;15:1-9.
35. Grubb BR. Ion transport across the jejunum in normal and cystic fibrosis mice. Am J Physiol 1995;268: G505-13.
36. Seidler U, Blumenstein I, Kietz A, et al. A functional CFTR protein is required for mouse intestinal cAMP-, cGMP- and Ca(2+)-dependent. J Physiol 1997;505:411-23.
37. Kimura Y, Okuda H, Kubo W. Effects of stilbenes isolated from medicinal plants en arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. J Ethnopharmacol 1995;45:131-9.
38. El Mowafy AM, White RE. Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects. FEBS Lett 1999;451:63-7.
39. Cermak R, Kuhn G, Wolffram S. The flavonol quercetin activates basolateral K(+) channels in rat distal colon epithelium. Br J Pharmacol 2002;135:1183-90.
40. Vidyasagar S, Ramakrishra BS. Effects of butyrate on active sodium and chloride transport in rat and rabbit distal colon. J Physiol 2002;539:163-73.
41. Moyer BD, Loffing-Cueni D, Loffing J, Reynolds D, Stanton BA. Butyrate increases apical membrane CFTR but reduces chloride secretion in MDCK cells. Am J Physiol 1999;277:F271-6.
42. Loffing J, Moyer BD, Reynolds D, Stanton BA. PBA increases CFTR expression but at high doses inhibits Cl(-) secretion in Calu-3 airway epithelial cells. Am J Physiol 1999;277:L700-8.
43. Zaharia V, Varzescu M, Djavadi I, et al. Effects of short chain fatty acids on colonic Na+ absorption and enzyme activity. Comp Biochem Physiol A Mol Integr Physiol 2001;128:335-47.
44. - secretory capacity by butyrate. J Clin Invest 1998;101:2072-79.