Anti-toxoplasmosis drugs

Current Opinion in Investigational Drugs

Volumn 2, Issue 10, 2001, Pages 1368-1374

  Derouin, F ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

Apicoplast; Atovaquone; Drug combination; Folate; Macrolide; Pyrimethamine; Sulfonamide; Toxoplasma gondii; Toxoplasmosis

Indexed keywords

ANTIINFECTIVE AGENT; ATOVAQUONE; AZITHROMYCIN; BIGUANIDE; CETHROMYCIN; CLINDAMYCIN; COTRIMOXAZOLE; DIHYDROFOLATE REDUCTASE INHIBITOR; EPIROPRIM; FOLIC ACID ANTAGONIST; GREPAFLOXACIN; HMR 3004; KETOLIDE; LINCOSAMIDE DERIVATIVE; MACROLIDE; N [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] N' ISOPROPYLIMIDOCARBONIMIDIC DIAMIDE; PHENOBARBITAL; PIRITREXIM; PYRIMETHAMINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPIRAMYCIN; SULFADIAZINE; SULFADOXINE; SULFAMETHOXAZOLE; SULFONAMIDE; SULFONE; TELITHROMYCIN; TRIMETHOPRIM; TRIMETREXATE; TROVAFLOXACIN; UNINDEXED DRUG;

ANTIMICROBIAL ACTIVITY; BINDING AFFINITY; CELL ORGANELLE; CLINICAL TRIAL; CYST; DOSE RESPONSE; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG POTENCY; DRUG POTENTIATION; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; ERADICATION THERAPY; HUMAN; INTESTINE ABSORPTION; NONHUMAN; RELAPSE; REVIEW; SKIN DISEASE; STRUCTURE ANALYSIS; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG COMBINATIONS; FOLIC ACID ANTAGONISTS; HUMANS; MACROLIDES; PYRIMETHAMINE; SULFONAMIDES; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMOSIS; TRIMETHOPRIM;

EID: 0034776893     PISSN: 09678298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Drugs effective against Toxoplasma gondii. Present status and future perspective
2. In vivo assessment of antimicrobial agents on Toxoplasma gondii by quantification of parasite in blood, lungs and brain of infected mice
3. Efficacy of epiroprim (Ro11-8958). A new dihydrofolate reductase inhibitor, in the treatment of acute Toxoplasma infection in mice
4. Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases
5. In vivo activity of the macrolide antibiotics azithromycin, roxithromycin and spiramycin against Toxoplasma gondii
6. Congenital toxoplasmosis: Systematic review of evidence of efficacy of treatment in pregnancy
7. Treatment of toxoplasmosis during pregnancy: A multicenter study of impact on fetal transmission and children's sequelae at age 1 year
8. Synergistic activity of azithromycin and pyrimethamine or sulfadiazine in acute experimental toxoplasmosis
9. Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii
10. Use of ketolides in combination with other drugs to treat experimental toxoplasmosis
11. Ketolide ABT-773 is active against Toxoplasma gondii
12. Quinupristindalfopristin is active against Toxoplasma gondii
13. Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii
14. In vitro and in vivo activities of the hydroxynapthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocyline against Toxoplasma gondii
15. Assessment of the activity of atovaquone-loaded nanocapsules in the treatment of acute and chronic murine toxoplasmosis
16. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis
17. Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance
18. Atovaquone for salvage treatment and suppression of toxoplasmic encephalitis with AIDS
19. Synergistic activity of clarithromycin and minocycline in an animal model of acute experimental toxoplasmosis
20. Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice
21. Anti-Toxoplasma activities and structure activity relationships of novel fluoroquinolones related to trovafloxacin
22. Anti-Toxoplasma activities of 24 quinolones and fluoroquinolones in vitro: Prediction of activity by molecular topology and virtual computational techniques
23. Activity of gatifloxacin alone or in combination with pyrimethamine or γ-interferon against Toxoplasma gondii
24. Toxoplasma gondii
25. Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome. Efficacy of long-term continuous therapy
26. Early and longitudinal evaluations of treated infants and children and untreated historical patterns with congenital toxoplasmosis: The Chicago Collaborative Treatment Trial
27. Pyrimethamine-sulfadoxine treatment of congenital toxoplasmosis: Follow-up of 78 cases between 1980 and 1997
28. Prophylaxis of toxoplasmosis infection with pyrimethamine/sulfadoxine (Fansidar) in bone marrow transplant recipients
29. Low dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS
30. Randomized trial of trimethoprim-sulfamethaxazole versus pyrimethamine-sulfadiazine for therapy of toxoplasmic encephalitis in patients with AIDS
31. Cotrimaxazole for prenatal treatment of congenital toxoplasmosis?
32. Folic acid antagonists during pregnancy and the risk of birth defects
33. Treatment of toxoplasmosis encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine
34. Dose-escalation, phase I/II study of azithromycin and pyrimethamine for the treatment of toxoplasmic encephalitis in AIDS
35. The activity of atovaquone (566C80) in murine toxoplasmosis is markedly augmented when used in combination with pyrimethamine or sulfadiazine
36. Synergistic effect of clindamycin and atovaquone in acute murine toxoplasmosis
37. Clarithromycin-minocycline combination as salvage therapy for toxoplasmosis in patients infected with human immunodeficiency virus
38. The effect of cyclosporine on Toxoplasma gondii in vivo and in vitro
39. Synergistic activity of azithromycin and γ-interferon in murine toxoplasmosis
40. Treatment with interleukin 12 in combination with atovaquone or clindamycin significantly increases survival of mice with acute toxoplasmosis
41. Anti-Toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro
42. Stopping primary prophylaxis in HIV-1 infected patients at high risk of Toxoplasma encephalitis. Swiss HIV Cohort Study
43. Immune recovery under highly active antiretroviral therapy is associated with restoration of lymphocyte proliferation and interferon-γ production in the presence of Toxoplasma gondii antigens
44. In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase
45. A plastid segregation defect in the protozoan parasite Toxoplasma gondii
46. The apicoplast: A new member of the plastid familly
47. The plastid in Apicomplexa: What use is it?
48. Evidence for the shikimate pathway in apicomplexan parasites
49. Inhibition of Toxoplasma gondii replication by dinitroaniline herbicides
50. Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of Apicomplexan Fabl
51. Paclitaxel arrests growth of intracellular Toxoplasma gondii
52. A plastid organelle as a drug target in apicomplexan parasites