Serotonin gene polymorphisms in patients with panic disorder

Actas Espanolas de Psiquiatria

Volumn 33, Issue 4, 2005, Pages 210-215

  Martinez Barrondo S ^a,c   Saiz, P A ^a   Morales, B ^b   Garcia Portilla M P ^a   Coto, E ^b   Alvarez V ^b   Bobes, J ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^c Faculty de Medicina   (Spain)

Author keywords

5 HT 2A polymorphisms; 5 HTT polymorphisms; Association study; Panic disorder

Indexed keywords

PRIMER DNA; SEROTONIN;

ADULT; ALLELE; ARTICLE; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; MALE; PANIC; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; ALLELES; DNA PRIMERS; FEMALE; HUMANS; MALE; MINISATELLITE REPEATS; PANIC DISORDER; POLYMORPHISM, GENETIC; SEROTONIN;

EID: 23044435274     PISSN: 11399287     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Massat I, Souery D, Lipp O, Blairy S, Papadimitriou G, Dikeos D, et al. A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder. Am J Med Genet 2000;96:136-40.
2. Sáiz PA, Morales B, G-Portilla MP, Álvarez V, Coto E, Fernández JM, et al. Apolipoprotein E genotype and schizophrenia: further negative evidence. Acta Psychitr Scand 2002;105:71-5.
3. Arango V, Huang Y, Underwood MD, Mann JJ. Genetics of the serotonergic system in suicidal behavior. J Psychiatr Res 2003;37:375-86.
4. Ferh C, Schleicher A, Szegedi A, Anghelescu I, Klavwe C, Hiemke C, et al. Serotoninergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:965-82.
5. National Institute of Mental Health. Health's Genetics Work-group. Genetics and mental disorders. Biol Psychiatry 1999;45:559-602.
6. Crowe RR, Noyes R, Pauls DL, Slymen D. A family study of panic disorder. Arch Gen Psychiatry 1983;40:1065-9.
7. Noyes R, Crowe RR, Harris EL, Hamra BJ, McChesney CM, Chaudhry DR. Relationship between panic disorder and agoraphobia. Arch Gen Psychiatry 1986;43:227-32.
8. Maier W, Lichtermann D, Minges J, Oehrlein A, Franke P. A controlled family study in panic disorder. J Psychiatr Res 1993;27:79-87.
9. Mendlewicz J, Papadimitriou G, Wilmotte J. Family study of panic disorder: comparison with generalized anxiety disorder, major depression, and normal subjects. Psychiatr Gen 1993;3:73-8.
10. Weissman MM, Wickramaratne P, Adams PB, Lish JD, Horwath E, Charney D, et al. The relationship between panic disorder and major depression: a family study. Arch Gen Psychiatry 1993;50:767-80.
11. Heun R, Maier W. Relation of schizophrenia and panic disorder: evidence from a controlled family study. Am J Med Genet 1995;60:127-32.
12. Slater E, Shields J. Genetic aspects of anxiety. En: Lader MH, editor. Studies of anxiety. London: Royal Medico Psychological Association; 1969; p. 62-71.
13. Torgersen S. Genetic factors in anxiety disorders. Arch Gen Psychiatry 1983;40:1085-9.
14. Torgersen S. Comorbidity of major depression and anxiety disorders in twin pairs. Am J Psychiatry 1990;147:1199-202.
15. Perna G, Caldirola D, Arancio C, Bellodi L. Panic attacks: a twin study. Psychiatry Res 1997;66:69-71.
16. Crowe RR. The genetics of panic disorder and agoraphobia. Psychiatr Dev 1985;3:171-85.
17. Crowe RR, Noyes R, Wilson AF, Elston RC, Ward LJ. A linkage study of panic disorder. Arch Gen Psychiatry 1987;44:933-7.
18. Nürnberger JI, Berrettini W. Psychiatric genetics. London: Chapman and Hall Medical, 1998.
19. Gratacòs M, Nadal M, Martin-Santos R, Pujana MA, Gago J, Peral B, et al. A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. Cells 2001;106:367-79.
20. Tabiner M, Youings S, Dennis N, Baldwin D, Buis C, Mayers A, et al. Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines. Am J Hum Genet 2003,72:535-8.
21. Schumacher J, Otte AC, Becker T, Sun Y, Wienker TF, Wirth B, et al. No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach. Hum Genet 2003;114:115-7.
22. 2 receptors in the rat brain: neurochemical identification of cell types by immunocytochemistry. Neuropsychopharmacol 1994;11:157-66.
23. Morales B, Saiz PA, Álvarez V, Coto E, Fernández JM, González MP, et al. Variación de los genes 5-HT2A y enzima conversiva de la angiotensina en pacientes esquizofrénicos. Psiquiatr Biol 2000;7:1-7.
24. Sáiz PA, Morales B, García-Portilla MP, Bascarán MT, Coto E, Álvarez V, et al. Polimorfismos serotoninérgicos y trastorno obsesivo-compulsivo. Psiquiatr Biológica 2001;8:219-24.
25. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-31.
26. Ebstein RP, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker RH. NO association between the serotonin transporter gene regulatory region polymorphism and the Tridimentional Personality Questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatr Genet 1997;7:45-7.
27. Nakamura T, Muramatsu T, Ono Y, Matsushita S, Higuchi S, Mizushima H, et al. Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese. Am J Med Genet 1997;74:544-5.
28. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, et al. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994;95:157-62.
29. World Medical Association. Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. Amended by 41st World Medical Assembly. Hong Kong, 1989.
30. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
31. Gutiérrez Martínez B, Rosa de la Cruz A. Introducción a la metodología para la identificación de los factores hereditarios. En: Fañanás L, Saiz J, editores. Manual de introducción a la genética en psiquiatría. Barcelona: Masson, 2000; p. 37-65.
32. Inada Y, Yoneda H, Koh J, Sakai J, Himei A, Kinoshita Y, et al. Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene. Psychiatry Res 2003;118:25-31.
33. Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, et al. Association between the serotonin transporter polymorphism and personality traits in a primary female population sample. Am J Genet 2000;96:202-16.
34. Du L, Bakish D, Hrdina PD. Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatr Genet 2000;10:159-64.
35. Melke J, Landen M, Baghei F, Rosmond R, Holm G, Bjorntorp P, et al. Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women. Am J Med Genet 2001;105:458-63.
36. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, et al. Serotonin transporter genetic variation and the response of human amygdala. Science 2002;297:400-3.
37. Hariri AR, Weinberger DR. Functional neuroimaging of genetic variation in serotoninergic neurotransmission. Genes Brain Behav 2003;2:341-9.
38. Caspi A, Sugden K, Moffit TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress in depression: moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-9.
39. Deckert J, Catalano M, Heils A, Di Bella D, Friess F, Politi E, et al. Functional promoter polymorphism of human serotonin transporter: lack of association with panic disorder. Psychiatr Genet 1997;7:45-7.
40. Ishiguro H, Arinami T, Yamada K, Otsuka Y, Toru M, Shibuya H. An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in Japanese population. Psychiatry Clin Neurosci 1997;51:333-5.
41. Matsushita S, Muramatsu T, Kimura M, Shirakawa O, Mita T, Nakai T, et al. Serotonin transporter gene regulatory region polymorphism and panic disorder. Mol Psychiatry 1997;2:390-2.
42. Hamilton SP, Heiman GA, Haghighi F, Mick S, Klein DF, Hodge SE, et al. Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder. Psychiatr Genet 1999;9:1-6.
43. Sand P, Lesch KP, Catalano M, Bosi M, Syagailo YV, Okladnova O, et al. Polymorphic MAO-A and 5-HT-transporter genes: analysis of interactions in panic disorder. World J Biol Psychiatry 2000;1:147-50.
44. Samochoviec J, Kmiñski R, Hajduk A, Stêpieñ G, Horodnicki J. Search for personality traits and other biological factors of anxiety disorders. Xth World Congress on Psychiatric Genetics. Bruselas, 2003.
45. Rotondo A, Mazzanti C, Dell'Osso L, Rucci P, Sullivan P, Bouanani S, et al. Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Am J Psychiatry 2002;159:23-9.
46. Rotondo A, Dell'Osso L, Bouanani S, Gonnelli C, Goldman D, Pardini L, et al. Comorbid panic disorder as a marker of genetic heterogeneity in bipolar disorder. San Francisco: American Psychiatric Association, 2003.
47. DiBella D, Perna G, Tentoni G, Bertani A, Cucchi M, Favaron E, et al. Panic disorder, treatment response and 5-HTT gene. San Francisco: American Psychiatric Association, 2003.
48. Ohara K, Suzuki Y, Ochiai M, Tsukamoto T, Tani K, Ohara K. A variable-number-tandem-repeat of the serotonin transporter gene and anxiety disorders. Prog Neuropsychopharmacol Biol Psychiatry 1999;23:55-65.