Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma

Life Sciences

Volumn 77, Issue 15, 2005, Pages 1869-1878

  Guo, Linlang ^a,b   Guo, Ying ^a   Xiao, Sha ^a   Shi, Xiaobao ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Activated protein 1 (AP 1); Hepatocellular carcinoma (HCC); Jun; Mitogen activated protein kinase (MAPK); Protein

Indexed keywords

STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CANCER CELL; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; VIRUS CARCINOGENESIS; VIRUS PATHOGENESIS;

CARCINOMA, HEPATOCELLULAR; CELL NUCLEUS; CYTOPLASM; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; TRANSCRIPTION FACTOR AP-1;

HEPATITIS B VIRUS;

EID: 23044433651     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.03.019     Document Type: Article

References (28)

1. P. Angel, and M. Karin The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation Biochimica et Biophysica Acta 1072 2-3 1991 129 157
2. M.A. Bae, and B.J. Song Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells Molecular Pharmacology 63 2 2003 401 408
3. J. Benn, F. Su, M. Doria, and R.J. Schneider Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases Journal of Virology 70 8 1996 4978 4985
4. D.A. Brenner Signal transduction during liver regeneration Journal of Gastroenterology and Hepatology 13 Supp l 1998 S93 S95
5. L. Chang, and M. Karin Mammalinan MAP kinase signaling cascades Nature 410 6824 2001 37 40
6. M.J. Czaja The future of GI and liver research: editorial perspectives: III. JNK/AP-1 regulation of hepatocyte death American Journal of Physiology: Gastrointestinal and Liver Physiology 284 6 2003 G875 G879
7. R. Eferl, R. Ricci, L. Kenner, R. Zenz, J.P. David, M. Rath, and E.F. Wagner Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53 Cell 112 2 2003 181 192
8. S. Finch, E. Joseloff, and T. Bowden JunB negatively regulates AP-1 activity and cell proliferation of malignant mouse keratinocytes Journal of Cancer Research and Clinical Oncology 128 1 2002 3 10
9. F. Henkler, and R. Koshy Hepatitis B virus transcriptional activators: mechanisms and possible role in oncogenesis Journal of Viral Hepatitis 3 3 1996 109 121
10. M.A. Hernandez-Presa, C. Gomez-Guerrero, and J. Egido In situ-nonradioactive detection of nuclear factors in paraffin sections by Southwestern histochemistry Kidney International 55 1 1999 209 214
11. M. Karin The regulation of AP-1 activity by mitogen-activated protein kinases The Journal of Biological Chemistry 270 28 1995 16483 16486
12. M. Karin, Z. Liu, and E. Zandi AP-1 function and regulation Current Opinion in Cell Biology 9 2 1997 240 246
13. J.M. Kyriakis, P. Banerjee, E. Nikolakaki, T. Dai, E.A. Rubie, M.F. Ahmad, J. Avruch, and J.R. Woodgett The stress-activated protein kinase subfamily of c-Jun kinases Nature 369 6476 1994 156 160
14. D.Z. Liao, A. Blanck, J.A. Gustafsson, and I.P. Hallstrom Expression of the c-jun, jun-B, ets-2 and liver regeneration factor-1 (LRF-1) genes during promotion and progression of rat liver carcinogenesis in the resistant hepatocyte model Cancer Letters 100 1-2 1996 215 221
15. L.L. Licato, and D.A. Brenner Analysis of signaling protein kinase in human colon or colorectal carcinomas Digestive Diseases and Sciences 43 7 1998 1454 1464
16. P. Liu, E. Kimmoun, A. Legrand, A. Sauvanet, C. Degott, B. Lardeux, and D. Bernuau Activation of NF-kappaB, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas Journal of Hepatology 37 1 2002 63 71
17. E. Minet, G. Michel, D. Mottet, J.P. Piret, A. Barbieux, M. Raes, and C. Michiels c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells Experimental Cell Research 265 1 2001 114 124
18. Y. Nakabeppu, K. Ryder, and D. Nathans DNA binding activities of three murine Jun proteins: stimulation by Fos Cell 55 5 1988 907 915
19. R. Nijhara, S.S. Jana, S.K. Goswami, A. Rana, S.S. Majumdar, V. Kumar, and D.P. Sarkar Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo Journal of Virology 75 21 2001 10348 10358
20. D.J. Papachristou, A. Batistatou, G.P. Sykiotis, I. Varakis, and A.G. Papavassiliou Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas Bone 32 4 2003 364 371
21. A.G. Papavassiliou, M. Treier, and D. Bohmann Intramolecular signal transduction in c-Jun The EMBO Journal 14 9 1995 2014 2019
22. E. Passegue, and E.F. Wagner JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression The EMBO Journal 19 12 2000 2969 2979
23. R.F. Schwabe, C.A. Bradham, T. Uehara, E. Hatano, B.L. Bennett, R. Schoonhoven, and D.A. Brenner c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration Hepatology 37 4 2003 824 832
24. H. Suzuki, H. Fujita, L. Mullauer, N. Kuzumaki, S. Konaka, Y. Togashi, N. Takeichi, Y. Kawamukai, and J. Uchino Increased expression of c-jun gene during spontaneous hepatocarcinogenesis in LEC rats Cancer Letters 53 2-3 1990 205 212
25. J.K. Westwick, C. Weitzel, H.L. Leffert, and D.A. Brenner Activation of Jun kinase is an early event in hepatic regeneration The Journal of Clinical Investigation 95 2 1995 803 810
26. A.J. Whitmarsh, and R.J. Davis Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways Journal Molecular Medicine 74 10 1996 589 607
27. G.M. Wulf, A. Ryo, G.G. Wulf, S.W. Lee, T. Niu, V. Petkova, and K.P. Lu Pinl is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1 The EMBO Journal 20 13 2001 3459 3472
28. L. Xiao, and W. Lang A dominant role of the c-Jun NH2-terminal kinase in oncogenic ras-induced morphologic transformation of human lung carcinoma cells Cancer Research 60 2 2000 400 408