-
3
-
-
2042457193
-
The buzz about a remarkable enzyme
-
A. M. Rouhi (2000) The buzz about a remarkable enzyme, Chem. Eng. News 78, 42-46.
-
(2000)
Chem. Eng. News
, vol.78
, pp. 42-46
-
-
Rouhi, A.M.1
-
4
-
-
10044293452
-
Editor's choice: Highlights from the recent literature
-
G. Chin (2000) Editor's choice: highlights from the recent literature, Science 288, 401-403.
-
(2000)
Science
, vol.288
, pp. 401-403
-
-
Chin, G.1
-
5
-
-
0034519315
-
Catalysis and regulation; clarity through structures
-
J. Stubbe, L. N. Johnson (2000) Catalysis and regulation; clarity through structures, Curr. Opin. Struct. Biol. 10, 709-710.
-
(2000)
Curr. Opin. Struct. Biol.
, vol.10
, pp. 709-710
-
-
Stubbe, J.1
Johnson, L.N.2
-
6
-
-
0035793649
-
Circe effect versus enzyme preorganization: What can be learned from the structure of the most proficient enzyme?
-
A. Warshel, J. Florian, M. Strabel, J. Villa (2001) Circe effect versus enzyme preorganization: what can be learned from the structure of the most proficient enzyme? ChemBioChem 2, 109-111.
-
(2001)
ChemBioChem
, vol.2
, pp. 109-111
-
-
Warshel, A.1
Florian, J.2
Strabel, M.3
Villa, J.4
-
7
-
-
0035793646
-
Crystal structures of orotidine monophosphate decarboxylase: Does the structure reveal the mechanism of nature's most proficient enzyme?
-
K. N. Houk, J. K. Lee, D. J. Tantillo, S. Bahmanyar, B. N. Hietbrink (2001) Crystal structures of orotidine monophosphate decarboxylase: does the structure reveal the mechanism of nature's most proficient enzyme? ChemBioChem 2, 113-118.
-
(2001)
ChemBioChem
, vol.2
, pp. 113-118
-
-
Houk, K.N.1
Lee, J.K.2
Tantillo, D.J.3
Bahmanyar, S.4
Hietbrink, B.N.5
-
8
-
-
0026517477
-
The orotidine-5′-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family
-
H. H. Kimsey, D. Kaiser (1992) The orotidine-5′-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family, J. Biol. Chem. 267, 819-824.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 819-824
-
-
Kimsey, H.H.1
Kaiser, D.2
-
9
-
-
0028918401
-
A proficient enzyme
-
A. Radzicka, R. Wolfenden (1995) A proficient enzyme, Science 267, 90-93.
-
(1995)
Science
, vol.267
, pp. 90-93
-
-
Radzicka, A.1
Wolfenden, R.2
-
10
-
-
0035574727
-
A re-examination of the substrate utilization of 2-thioorotidine- 5′-monophosphate by yeast OMP decarboxylase
-
J. A. Smiley, K. M. Hay, B. S. Levison (2001) A re-examination of the substrate utilization of 2-thioorotidine-5′-monophosphate by yeast OMP decarboxylase, Bioorg. Chem. 29, 96-106.
-
(2001)
Bioorg. Chem.
, vol.29
, pp. 96-106
-
-
Smiley, J.A.1
Hay, K.M.2
Levison, B.S.3
-
11
-
-
0035805488
-
Dissecting a charged network at the active site of orotidine-5′- phosphate decarboxylase
-
B. G. Miller, M. J. Snider, R. Wolfenden, S. A. Short (2001) Dissecting a charged network at the active site of orotidine-5′-phosphate decarboxylase, J. Biol. Chem. 276, 15174-15176.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 15174-15176
-
-
Miller, B.G.1
Snider, M.J.2
Wolfenden, R.3
Short, S.A.4
-
12
-
-
0034682613
-
Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5′-phosphate decarboxylase
-
B. G. Miller, M. J. Snider, S. A. Short, R. Wolfenden (2000) Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5′-phosphate decarboxylase, Biochemistry 39, 8113-8118.
-
(2000)
Biochemistry
, vol.39
, pp. 8113-8118
-
-
Miller, B.G.1
Snider, M.J.2
Short, S.A.3
Wolfenden, R.4
-
13
-
-
0034718457
-
Yeast orotidine-5′-phosphate decarboxylase: Steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation
-
D. J. Porter, S. A. Short (2000) Yeast orotidine-5′-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation, Biochemistry 39, 11788-11800.
-
(2000)
Biochemistry
, vol.39
, pp. 11788-11800
-
-
Porter, D.J.1
Short, S.A.2
-
14
-
-
0038998655
-
Determination of the mechanism of orotidine-5′-monophosphate decarboxylase by isotope effects
-
M. A. Rishavy, W. W. Cleland (2000) Determination of the mechanism of orotidine-5′-monophosphate decarboxylase by isotope effects, Biochemistry 39, 4569-4574.
-
(2000)
Biochemistry
, vol.39
, pp. 4569-4574
-
-
Rishavy, M.A.1
Cleland, W.W.2
-
15
-
-
0034058368
-
The crystal structure and mechanism of orotidine-5′-monophosphate decarboxylase
-
T. C. Appleby, C. Kinsland, T. P. Begley, S. E. Ealick (2000) The crystal structure and mechanism of orotidine-5′-monophosphate decarboxylase, Proc. Nat. Acad. Sci. U. S. A. 97, 2005-2010.
-
(2000)
Proc. Nat. Acad. Sci. U. S. A.
, vol.97
, pp. 2005-2010
-
-
Appleby, T.C.1
Kinsland, C.2
Begley, T.P.3
Ealick, S.E.4
-
16
-
-
0034104285
-
Anatomy of a proficient enzyme: The structure of orotidine-5′- monophosphate decarboxylase in the presence and absence of a potential transition state analog
-
B. G. Miller, A. M. Hassell, R. Wolfenden, M. V. Milburn, S. A. Short (2000) Anatomy of a proficient enzyme: the structure of orotidine-5′- monophosphate decarboxylase in the presence and absence of a potential transition state analog, Proc. Nat. Acad. Sci U. S. A. 97, 2011-2016.
-
(2000)
Proc. Nat. Acad. Sci U. S. A.
, vol.97
, pp. 2011-2016
-
-
Miller, B.G.1
Hassell, A.M.2
Wolfenden, R.3
Milburn, M.V.4
Short, S.A.5
-
17
-
-
0034102419
-
Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase
-
N. Wu, Y. Mo, J. Gao, E. F. Pai (2000) Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase, Proc. Nat. Acad. Sci. U. S. A. 97, 2017-2022.
-
(2000)
Proc. Nat. Acad. Sci. U. S. A.
, vol.97
, pp. 2017-2022
-
-
Wu, N.1
Mo, Y.2
Gao, J.3
Pai, E.F.4
-
18
-
-
0034681950
-
Structural basis for the catalytic mechanism of a proficient enzyme: Orotidine-5′-monophosphate decarboxylase
-
P. Harris, J. C. Navarro-Poulsen, K. F. Jensen, S. Larsen (2000) Structural basis for the catalytic mechanism of a proficient enzyme: orotidine-5′-monophosphate decarboxylase, Biochemistry 39, 4217-4224.
-
(2000)
Biochemistry
, vol.39
, pp. 4217-4224
-
-
Harris, P.1
Navarro-Poulsen, J.C.2
Jensen, K.F.3
Larsen, S.4
-
19
-
-
0000264492
-
The mechanism of orotidine-5′-monophosphate decarboxylase: Catalysis by destabilization of the substrate
-
W. Y. Feng, T. J. Austin, F. Chew, S. Gronert, W. Wu (2000) The mechanism of orotidine-5′-monophosphate decarboxylase: catalysis by destabilization of the substrate, Biochemistry 39, 1778-1783.
-
(2000)
Biochemistry
, vol.39
, pp. 1778-1783
-
-
Feng, W.Y.1
Austin, T.J.2
Chew, F.3
Gronert, S.4
Wu, W.5
-
20
-
-
0034610398
-
Remarkable rate enhancement of orotidine-5′-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization
-
A. Warshel, M. Strajbl, J. Villa, J. Florian (2000) Remarkable rate enhancement of orotidine-5′-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization, Biochemistry 39, 14728-14738.
-
(2000)
Biochemistry
, vol.39
, pp. 14728-14738
-
-
Warshel, A.1
Strajbl, M.2
Villa, J.3
Florian, J.4
-
21
-
-
0034639902
-
13C kinetic isotope effects and the mechanism of the uncatalyzed decarboxylation of orotic acid
-
13C kinetic isotope effects and the mechanism of the uncatalyzed decarboxylation of orotic acid, J. Am. Chem. Soc. 122, 3296-3300.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 3296-3300
-
-
Singelton, D.A.1
Merrigan, S.A.2
Kim, B.J.3
Beak, P.4
Phillips, L.M.5
Lee, J.K.6
-
22
-
-
0032817361
-
Active site probes for yeast OMP decarboxylase: Inhibition constants of UMP and thio-substituted UMP analogues and greatly reduced activity toward CMP-6-carboxylate
-
J. A. Smiley, L. Saleh (1999) Active site probes for yeast OMP decarboxylase: inhibition constants of UMP and thio-substituted UMP analogues and greatly reduced activity toward CMP-6-carboxylate, Bioorg. Chem. 27, 297-306.
-
(1999)
Bioorg. Chem.
, vol.27
, pp. 297-306
-
-
Smiley, J.A.1
Saleh, L.2
-
23
-
-
0033588155
-
Activity of yeast orotidine-5′-phosphate decarboxylase in the absence of metals
-
B. G. Miller, J. A. Smiley, S. A. Short, R. Wolfenden (1999) Activity of yeast orotidine-5′-phosphate decarboxylase in the absence of metals, J. Biol. Chem. 274, 23841-23843.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23841-23843
-
-
Miller, B.G.1
Smiley, J.A.2
Short, S.A.3
Wolfenden, R.4
-
24
-
-
0033612737
-
Evidence for a stepwise mechanism of OMP decarboxylase
-
J. I. Ehrlich, C.-C. Hwang, P. F. Cook, J. S. Blanchard (1999) Evidence for a stepwise mechanism of OMP decarboxylase, J. Am. Chem. Soc. 121, 6966-6967.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 6966-6967
-
-
Ehrlich, J.I.1
Hwang, C.-C.2
Cook, P.F.3
Blanchard, J.S.4
-
25
-
-
0030912339
-
A proficient enzyme revisited: The predicted mechanism for orotidine monophosphate decarboxylase
-
J. K. Lee, K. N. Houk (1997) A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase, Science 276, 942-945.
-
(1997)
Science
, vol.276
, pp. 942-945
-
-
Lee, J.K.1
Houk, K.N.2
-
26
-
-
0028938397
-
Expression of an orotate decarboxylating catalytic antibody confers 5-fluoro-orotate sensitivity to a pyrimidine auxotrophic Escherichia coli: An example of intracellular prodrug activation
-
J. A. Smiley, S. J. Benkovic (1995) Expression of an orotate decarboxylating catalytic antibody confers 5-fluoro-orotate sensitivity to a pyrimidine auxotrophic Escherichia coli: an example of intracellular prodrug activation, J. Am. Chem. Soc. 117, 3877-3878.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 3877-3878
-
-
Smiley, J.A.1
Benkovic, S.J.2
-
27
-
-
0028068780
-
Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichia coli: Antibodies for orotate decarboxylation
-
J. A. Smiley, S. J. Benkovic (1994) Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichia coli: antibodies for orotate decarboxylation, Proc. Natl. Acad. Sci U. S. A. 91, 8319-8323.
-
(1994)
Proc. Natl. Acad. Sci U. S. A.
, vol.91
, pp. 8319-8323
-
-
Smiley, J.A.1
Benkovic, S.J.2
-
28
-
-
0026622110
-
A unique catalytic and inhibitor-binding role for Lys93 of yeast orotidylate decarboxylase
-
J. A. Smiley, M. E. Jones (1992) A unique catalytic and inhibitor-binding role for Lys93 of yeast orotidylate decarboxylase, Biochemistry 31, 12162-12168.
-
(1992)
Biochemistry
, vol.31
, pp. 12162-12168
-
-
Smiley, J.A.1
Jones, M.E.2
-
29
-
-
0026677723
-
Orotidylate decarboxylase: Insights into the catalytic mechanism from substrate-specificity studies
-
K. Shostak, M. E. Jones (1992) Orotidylate decarboxylase: insights into the catalytic mechanism from substrate-specificity studies, Biochemistry 31, 12155-12161.
-
(1992)
Biochemistry
, vol.31
, pp. 12155-12161
-
-
Shostak, K.1
Jones, M.E.2
-
30
-
-
0025775806
-
Investigation of the enzymatic mechanism of yeast orotidine-5′- monophosphate decarboxylase using C-13 kinetic isotope effects
-
J. A. Smiley, P. Paneth, M. H. O'Leary, J. B. Bell, M. E. Jones (1991) Investigation of the enzymatic mechanism of yeast orotidine-5′- monophosphate decarboxylase using C-13 kinetic isotope effects, Biochemistry 30, 6216-6223.
-
(1991)
Biochemistry
, vol.30
, pp. 6216-6223
-
-
Smiley, J.A.1
Paneth, P.2
O'Leary, M.H.3
Bell, J.B.4
Jones, M.E.5
-
31
-
-
0025272740
-
Orotidine-5′-monophosphate decarboxylase catalysis: Kinetic isotope effects and the state of hybridization of a bound transition-state analog
-
S. A. Acheson, J. B. Bell, M. E. Jones, R. Wolfenden (1990) Orotidine-5′-monophosphate decarboxylase catalysis: kinetic isotope effects and the state of hybridization of a bound transition-state analog, Biochemistry 29, 3198-3202.
-
(1990)
Biochemistry
, vol.29
, pp. 3198-3202
-
-
Acheson, S.A.1
Bell, J.B.2
Jones, M.E.3
Wolfenden, R.4
-
32
-
-
0019334745
-
Inhibition of orotidine-5′-phosphate decarboxylase by 1-(5′-phospho-β-D-ribofuranosyl)barbituric acid, 6-azauridine 5′-phosphate, and uridine 5′- phosphate
-
H. L. Levine, R. S. Brody, F. H. Westheimer (1980) Inhibition of orotidine-5′-phosphate decarboxylase by 1-(5′-phospho-β-D- ribofuranosyl)barbituric acid, 6-azauridine 5′-phosphate, and uridine 5′- phosphate, Biochemistry 19, 4993-4999.
-
(1980)
Biochemistry
, vol.19
, pp. 4993-4999
-
-
Levine, H.L.1
Brody, R.S.2
Westheimer, F.H.3
-
33
-
-
0017302117
-
Mechanism of decarboxylation of 1,3-dimethylorotic acid. A model for orotidine-5′-phosphate decarboxylase
-
P. Beak, B. Siegel (1976) Mechanism of decarboxylation of 1,3-dimethylorotic acid. A model for orotidine-5′-phosphate decarboxylase, J. Am. Chem. Soc. 98, 3601-3606.
-
(1976)
J. Am. Chem. Soc.
, vol.98
, pp. 3601-3606
-
-
Beak, P.1
Siegel, B.2
-
34
-
-
0025874328
-
Purification and characterization of yeast orotidine 5′- monophosphate decarboxylase overexpressed from plasmid pGU2
-
J. B. Bell, M. E. Jones (1991) Purification and characterization of yeast orotidine 5′-monophosphate decarboxylase overexpressed from plasmid pGU2, J. Biol. Chem. 266, 12662-12667.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 12662-12667
-
-
Bell, J.B.1
Jones, M.E.2
-
35
-
-
0018169995
-
Conversion of uridine nucleotides to the 6-cyano derivatives: Synthesis of orotidylic acid
-
T. Ueda, M. Yamamoto, A. Yamane, M. Imazawa, H. Ioue (1978) Conversion of uridine nucleotides to the 6-cyano derivatives: synthesis of orotidylic acid, J. Carbohydr. 5, 261-271.
-
(1978)
J. Carbohydr.
, vol.5
, pp. 261-271
-
-
Ueda, T.1
Yamamoto, M.2
Yamane, A.3
Imazawa, M.4
Ioue, H.5
-
36
-
-
0022511769
-
Sequence analysis of the pyr-4 (orotidine-5′-phosphate decarboxylase) gene of Neurospora crassa
-
S. F. Newbury, J. A. Glazebrook, A. Radford (1986) Sequence analysis of the pyr-4 (orotidine-5′-phosphate decarboxylase) gene of Neurospora crassa, Gene (Amst.) 43, 51-58.
-
(1986)
Gene (Amst.)
, vol.43
, pp. 51-58
-
-
Newbury, S.F.1
Glazebrook, J.A.2
Radford, A.3
-
38
-
-
0004270170
-
-
F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, K. Struhl, Eds., Greene Publishing Associates and John Wiley & Sons, Inc., New York
-
F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, K. Struhl, Eds. (1994) Current Protocols in Molecular Biology, Greene Publishing Associates and John Wiley & Sons, Inc., New York.
-
(1994)
Current Protocols in Molecular Biology
-
-
-
39
-
-
0018362441
-
The purification of orotidine-5′-phosphate decarboxylase from yeast by affinity chromatography
-
R. S. Brody, F. H. Westheimer (1979) The purification of orotidine-5′-phosphate decarboxylase from yeast by affinity chromatography, J. Biol. Chem. 254, 4238-4244.
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 4238-4244
-
-
Brody, R.S.1
Westheimer, F.H.2
|