2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A2A antagonists. Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 16, 2005, Pages 3670-3674

  Matasi, Julius J ^a   Caldwell, John P ^a   Zhang, Hongtao ^a   Fawzi, Ahmad ^a   Cohen Williams, Mary E ^a   Varty, Geoffrey B ^a   Tulshian, Deen B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Adenosine receptor; Antagonist; Arylindenopyrimidines

Indexed keywords

2 (2 FURANYL) 7 PHENYL[1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 5 AMINE; ADENOSINE A2A RECEPTOR ANTAGONIST; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CATALEPSY; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; MALE; MOLECULAR STRUCTURE; PYRIMIDINES; RATS; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 22844440107     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.086     Document Type: Article

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