Effect of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in rats

Annals of Nutrition and Metabolism

Volumn 49, Issue 1, 2005, Pages 49-53

  Valenzuela, Alfonso ^a,b   Valenzuela, Viviana ^a   Sanhueza, Julio ^b   Nieto, Susana ^b  

^a UNIVERSIDAD DE LOS ANDES   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Docosahexaenoic acid bioavailability; Docosahexaenoic acid supplementation; Erythrocyte fatty acid composition; Plasma fatty acid composition

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; DOCOSAHEXAENOIC ACID ETHYL ESTER; SN 2 DOCOSAHEXAENYL MONOACYLGLYCERIDE; UNCLASSIFIED DRUG; 4,7,10,13,16,19 DOCOSAHEXAENOIC ACID ETHYL ESTER; 4,7,10,13,16,19-DOCOSAHEXAENOIC ACID ETHYL ESTER; EDIBLE OIL; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; ERYTHROCYTE; FEMALE; GAS CHROMATOGRAPHY; LIPID COMPOSITION; LIPID DIET; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD; CHEMISTRY; ERYTHROCYTE MEMBRANE; INTESTINE ABSORPTION; METABOLISM; RANDOMIZATION; WISTAR RAT;

ALGAE; MAMMALIA;

ANIMALS; ARACHIDONIC ACID; CHROMATOGRAPHY, GAS; DIETARY FATS, UNSATURATED; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; ERYTHROCYTE MEMBRANE; FATTY ACIDS, UNSATURATED; FEMALE; INTESTINAL ABSORPTION; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 22844436453     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000084177     Document Type: Article

References (21)

1. Uauy R, Treen M, Hoffmann DR: Essential fatty acid metabolism and requirements during development. Semin Perinatol 1989;13:118-130.
2. Carlson S, Neuringer M: Polyunsaturated fatty acid status and neurodevelopment: A summary and critical analysis of the literature. Lipids 1999;34:171-178.
3. Clandinin MT: Brain development and assessing the supply of polyunsaturated fatty acids. Lipids 1999;34:131-137.
4. Jensen RG: The lipids in human milk. Prog Lipid Res 1996;35:53-92.
5. Simopoulos AP, Leaf A, Salem N: Essentially and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann Nutr Metab 1999;43:127-130.
6. Koletzko B, Sinclair A: Long-chain polyunsaturated fatty acids in diets for infants: Choices for recommending and regulating bodies and for manufacturers of dietary products. Lipids 1999;34:215-220.
7. Koo W: Efficacy and safety of docosahexaenoic acid and arachidonic acid addition to infant formulas: Can one buy better vision and intelligence? J Am Coll Nutr 2003;22:101-107.
8. Uauy R, Valenzuela A: Marine oils: The health benefits of n-3 fatty acids. Nutrition 2000;16:680-684.
9. Nieto S, Gutierrez J, Sanhueza J, Valenzuela A: Preparation of sn-2 long-chain polyunsaturated monoacylglycerols from fish oil by hydrolysis with a stereospecific lipase from Mucor miehei. Grasas & Aceites 1999;50:111-113.
10. Bracco H: Effect of triglyceride structure on fat absorption. Am J Clin Nutr 1994;60(suppl):S1002-S1009.
11. Decsi T, Koletzko B: Polyunsaturated fatty acid in infant nutrition. Acta Paediatr Suppl 1994;395:31-37.
12. Saito M, Oh-Hashi A, Kuborta M, Nishide E, Yamagushi M: Mixed function oxidases in response to different types of dietary lipids in rats. Br J Nutr 1990;63:249-257.
13. Bligh E, Dyer W: A rapid method of total lipid extraction and purification. Can J Physiol 1959;37:911-917.
14. Morrison W, Smith LM: Preparation of fatty acid methyl esters and dimethyl acetals from lipids with boron fluoride-methanol. J Lipid Res 1964;25:600-608.
15. Duncan DB: Multiple range test for correlated and heterocedastics means. Biometrics 1957;13:164-176.
16. Wallace J, McCabe A, Robson P, Keogh M, Murray C, Kelly P, Márquez-Ruiz G, McGlynn H, Gilmore W, Strain J: Bioavailability of n-3 polyunsaturated fatty acids (PUFA) in foods enriched with microencapsulated fish oil. Ann Nutr Metab 2000;44:157-162.
17. Sprecher H, Luthria D, Mohamed B, Baykousheva S: Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J Lipid Res 1995;36:2471-2477.
18. Lawson L, Hughes B: Human absorption of fish oil fatty acids as triacylglycerols, free fatty acids, or ethyl esters. Biochim Biophys Acta 1988;152:328-335.
19. Zuijdgeest-van Leeuwen S, Dagniele P, Rietvelt T, Willem J, van den Berg O, Wilson JHP: Incorporation and washout of orally administered n-3 fatty acid ethyl esters in different plasma lipid fraction. Br J Nutr 1999;82:481-488.
20. Valenzuela A, von Bernhardi R, Valenzuela V, Ramírez G, Alarcón R, Sanhueza J, Nieto S: Supplementation of female rats with alpha-linolenic (LNA) or docosahexaenoic acid (DHA) leads to the same omega-6/omega-3 LC-PUFA accretion in mother tissues and in the fetal and newborn brain. Ann Nutr Metab 2004;48:28-35.
21. Thomson A, Keelan M, Garg M, Clandinin M: Intestinal aspects of lipid absorption: In review. Can J Physiol Pharmacol 1988;67:179-191.