-
1
-
-
0020118322
-
A convenient procedure for purification of thymidylate synthase from L1210 cells
-
Banerjee, C. K., L. L. Bennett, Jr., R. W. Brockman, B. P. Sani, and C. Temple, Jr. 1982. A convenient procedure for purification of thymidylate synthase from L1210 cells. Anal. Biochem. 121:275-280.
-
(1982)
Anal. Biochem.
, vol.121
, pp. 275-280
-
-
Banerjee, C.K.1
Bennett Jr., L.L.2
Brockman, R.W.3
Sani, B.P.4
Temple Jr., C.5
-
2
-
-
0001651897
-
Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthetase gene
-
Bzik, D. J., W. Li, T. Horii, and J. Insulburg. 1987. Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthetase gene. Proc. Natl. Acad. Sci. USA 84:8360-8364.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 8360-8364
-
-
Bzik, D.J.1
Li, W.2
Horii, T.3
Insulburg, J.4
-
3
-
-
0029036377
-
The catalytic mechanism and structure of thymidylate synthase
-
Carreras, C. W., and D. V. Santi. 1995. The catalytic mechanism and structure of thymidylate synthase. Annu. Rev. Biochem. 64:721-762.
-
(1995)
Annu. Rev. Biochem.
, vol.64
, pp. 721-762
-
-
Carreras, C.W.1
Santi, D.V.2
-
4
-
-
0023497634
-
Purification of the bifunctional thymidylate synthase-dihydrofolate reductase complex from the human malaria parasite Plasmodium falciparum
-
Chen, G., and J. W. Zolg. 1987. Purification of the bifunctional thymidylate synthase-dihydrofolate reductase complex from the human malaria parasite Plasmodium falciparum. Mol. Pharmacol. 32:723-730.
-
(1987)
Mol. Pharmacol.
, vol.32
, pp. 723-730
-
-
Chen, G.1
Zolg, J.W.2
-
5
-
-
0008614282
-
Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica
-
Coderre, J. A., S. M. Beverly, T. R. Schimke, and D. V. Santi. 1983. Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc. Natl. Acad. Sci. USA 80:2132-2136.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 2132-2136
-
-
Coderre, J.A.1
Beverly, S.M.2
Schimke, T.R.3
Santi, D.V.4
-
6
-
-
33947093786
-
Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5′-fluoro-2′-deoxyuridylate from thymidylate synthase: Evidence for an ordered mechanism
-
Danenberg, P. V., and K. D. Danenberg. 1978. Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5′-fluoro-2′-deoxyuridylate from thymidylate synthase: evidence for an ordered mechanism. Biochemistry 17:4018-4024.
-
(1978)
Biochemistry
, vol.17
, pp. 4018-4024
-
-
Danenberg, P.V.1
Danenberg, K.D.2
-
7
-
-
0019383730
-
Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase
-
Danenberg, P. V., and A. Lockshin. 1981. Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase. Pharmacol. Ther. 13:69-90.
-
(1981)
Pharmacol. Ther.
, vol.13
, pp. 69-90
-
-
Danenberg, P.V.1
Lockshin, A.2
-
8
-
-
0024333859
-
Expression of human thymidylate synthase in Escherichia coli
-
Davisson, V. J., W. Sirawaraporn, and D. V. Santi. 1989. Expression of human thymidylate synthase in Escherichia coli. J. Biol. Chem. 264:9145-9148.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 9145-9148
-
-
Davisson, V.J.1
Sirawaraporn, W.2
Santi, D.V.3
-
9
-
-
0017727278
-
Human thymidylate synthetase derived from blast cells of patients with acute myelocytic leukemia. Purification and characterization
-
Dolnick, B. J., and Y.-C. Cheng. 1977. Human thymidylate synthetase derived from blast cells of patients with acute myelocytic leukemia. Purification and characterization. J. Biol. Chem. 252:7697-7703.
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 7697-7703
-
-
Dolnick, B.J.1
Cheng, Y.-C.2
-
10
-
-
0014442219
-
Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates
-
Ferone, R., J. J. Burchall, and G. H. Hitchings. 1969. Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates. Mol. Pharmacol. 5:49-59.
-
(1969)
Mol. Pharmacol.
, vol.5
, pp. 49-59
-
-
Ferone, R.1
Burchall, J.J.2
Hitchings, G.H.3
-
11
-
-
0019179251
-
Dihydrofolate reductase: Thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata
-
Ferone, R., and S. Roland. 1980. Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata. Proc. Natl. Acad. Sci. USA 77:5802-5806.
-
(1980)
Proc. Natl. Acad. Sci. USA
, vol.77
, pp. 5802-5806
-
-
Ferone, R.1
Roland, S.2
-
12
-
-
0021287749
-
A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa
-
Garrett, C. E., J. A. Coderre, T. D. Meek, E. P. Garvey, D. Claman, S. M. Beverly, and D. V. Santi. 1984. A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa. Mol. Biochem. Parasitol. 11:257-265.
-
(1984)
Mol. Biochem. Parasitol.
, vol.11
, pp. 257-265
-
-
Garrett, C.E.1
Coderre, J.A.2
Meek, T.D.3
Garvey, E.P.4
Claman, D.5
Beverly, S.M.6
Santi, D.V.7
-
13
-
-
0025281764
-
Antimalarial activity of a 5-fluoroorotate and uridine combination in mice
-
Gomez, Z., and P. K. Rathod. 1990. Antimalarial activity of a 5-fluoroorotate and uridine combination in mice. Antimicrob. Agents Chemother. 34:1371-1375.
-
(1990)
Antimicrob. Agents Chemother.
, vol.34
, pp. 1371-1375
-
-
Gomez, Z.1
Rathod, P.K.2
-
14
-
-
0014740189
-
Incorporation of radioactive precursors into DNA and RNA of Plasmodium knowlesi in vitro
-
Gutteridge, W. E., and P. I. Trigg. 1970. Incorporation of radioactive precursors into DNA and RNA of Plasmodium knowlesi in vitro. J. Protozool. 17:89-96.
-
(1970)
J. Protozool.
, vol.17
, pp. 89-96
-
-
Gutteridge, W.E.1
Trigg, P.I.2
-
15
-
-
0026066990
-
Functional expression of the dihydrofolate reduclase and thymidylate synthase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli
-
Hall, S. J., P. F. G. Sims, and J. Hyde. 1991. Functional expression of the dihydrofolate reduclase and thymidylate synthase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli. Mol. Biochem. Parasitol. 45:317-330.
-
(1991)
Mol. Biochem. Parasitol.
, vol.45
, pp. 317-330
-
-
Hall, S.J.1
Sims, P.F.G.2
Hyde, J.3
-
16
-
-
0017317663
-
Culture of human malaria parasites, Plasmodium falciparum
-
Haynes, J. D., C. L. Diggs, F. A. Hines, and R. E. Desjardines. 1976. Culture of human malaria parasites, Plasmodium falciparum. Nature (London) 263: 767-769.
-
(1976)
Nature (London)
, vol.263
, pp. 767-769
-
-
Haynes, J.D.1
Diggs, C.L.2
Hines, F.A.3
Desjardines, R.E.4
-
18
-
-
2642696023
-
Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency
-
Houghton, P. J., G. S. Germain, B. J. Hazelton, J. W. Pennington, and J. A. Houghton. 1989. Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency. Proc. Natl. Acad. Sci. USA 86:1377-1381.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 1377-1381
-
-
Houghton, P.J.1
Germain, G.S.2
Hazelton, B.J.3
Pennington, J.W.4
Houghton, J.A.5
-
19
-
-
0022506923
-
DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate
-
Ingraham, H. A., L. Dickey, and M. Goulian. 1986. DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate. Biochemistry 25:3225-3230.
-
(1986)
Biochemistry
, vol.25
, pp. 3225-3230
-
-
Ingraham, H.A.1
Dickey, L.2
Goulian, M.3
-
20
-
-
0025997350
-
ICI D1694, a quinozoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
-
Jackman, A. L., G. A. Taylor, W. Gibson, R. Kimbel, M. Brown, A. H. Calvert, I. R. Judson, and L. R. Hughes. 1991. ICI D1694, a quinozoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Res. 51:5579-5586.
-
(1991)
Cancer Res.
, vol.51
, pp. 5579-5586
-
-
Jackman, A.L.1
Taylor, G.A.2
Gibson, W.3
Kimbel, R.4
Brown, M.5
Calvert, A.H.6
Judson, I.R.7
Hughes, L.R.8
-
21
-
-
0028322120
-
Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability
-
Kuntz, B. A., S. E. Kohalmi, T. A. Kunkel, C. K. Mathews, et al. 1994. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability. Mutat. Res. 318:1-64.
-
(1994)
Mutat. Res.
, vol.318
, pp. 1-64
-
-
Kuntz, B.A.1
Kohalmi, S.E.2
Kunkel, T.A.3
Mathews, C.K.4
-
22
-
-
0343970310
-
-
A. S. V. Burger and G. C. K. Roberts (ed.), Elsevier/North-Holland Biomedical Press, New York
-
Lewis, C. A., and R. B. Dunlap. 1981. In A. S. V. Burger and G. C. K. Roberts (ed.), Topics in molecular biology, p. 169-219. Elsevier/North-Holland Biomedical Press, New York.
-
(1981)
Topics in Molecular Biology
, pp. 169-219
-
-
Lewis, C.A.1
Dunlap, R.B.2
-
23
-
-
0000423899
-
Thymidylate synthase purified to homogeneity from human leukemia cells
-
Lockshin, A., R. G. Moran, and P. V. Danenberg. 1979. Thymidylate synthase purified to homogeneity from human leukemia cells. Proc. Natl. Acad. Sci. USA 76:750-754.
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 750-754
-
-
Lockshin, A.1
Moran, R.G.2
Danenberg, P.V.3
-
24
-
-
0003806169
-
-
National Academy Press, Washington, D.C.
-
Oaks, S. C., Jr., V. S. Mitchell, G. W. Pearson, and C. C. J. Pearson (ed.). 1991. Malaria. Obstacles and opportunities. National Academy Press, Washington, D.C.
-
(1991)
Malaria. Obstacles and Opportunities
-
-
Oaks Jr., S.C.1
Mitchell, V.S.2
Pearson, G.W.3
Pearson, C.C.J.4
-
25
-
-
0023921794
-
Plasmodium falciparum: Cloning by single erythrocyte manipulation and heterogeneity in vitro
-
Oduola, A. M. J., N. F. Weatherly, J. H. Bowdre, and R. E. Desjardins. 1988. Plasmodium falciparum: cloning by single erythrocyte manipulation and heterogeneity in vitro. Exp. Parasitol. 66:86-95.
-
(1988)
Exp. Parasitol.
, vol.66
, pp. 86-95
-
-
Oduola, A.M.J.1
Weatherly, N.F.2
Bowdre, J.H.3
Desjardins, R.E.4
-
26
-
-
0021904294
-
Comparative studies on thymidylate synthetase from P. berghei and mouse reticulocytes
-
Pattanakitsakul, S.-N., A. Ratanaphan, and P. Ruenwongsa. 1985. Comparative studies on thymidylate synthetase from P. berghei and mouse reticulocytes. Comp. Biochem. Physiol. 808:583-587.
-
(1985)
Comp. Biochem. Physiol.
, vol.808
, pp. 583-587
-
-
Pattanakitsakul, S.-N.1
Ratanaphan, A.2
Ruenwongsa, P.3
-
27
-
-
0023840063
-
Characteristics of thymidylate synthase purified from a human colon adenocarcinoma
-
Radparvar, S., P. J. Houghton, and J. A. Houghton. 1988. Characteristics of thymidylate synthase purified from a human colon adenocarcinoma. Arch. Biochem. Biophys. 260:342-350.
-
(1988)
Arch. Biochem. Biophys.
, vol.260
, pp. 342-350
-
-
Radparvar, S.1
Houghton, P.J.2
Houghton, J.A.3
-
28
-
-
0026251337
-
Plasmodium yoelii: Oral delivery of 5-fluoroorotate to treat malaria in mice
-
Rathod, P. K., and Z. M. Gomez. 1991. Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice. Exp. Parasitol. 73:512-514.
-
(1991)
Exp. Parasitol.
, vol.73
, pp. 512-514
-
-
Rathod, P.K.1
Gomez, Z.M.2
-
29
-
-
0024400016
-
Selective activity of 5-fluoroorotate against Plasmodium falciparum in vitro
-
Rathod, P. K., A. Khatri, T. Hubbert, and W. K. Milhous. 1989. Selective activity of 5-fluoroorotate against Plasmodium falciparum in vitro. Antimicrob. Agents Chemother. 33:1090-1094.
-
(1989)
Antimicrob. Agents Chemother.
, vol.33
, pp. 1090-1094
-
-
Rathod, P.K.1
Khatri, A.2
Hubbert, T.3
Milhous, W.K.4
-
30
-
-
0026510588
-
Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum
-
Rathod, P. K., N. P. Leffers, and R. D. Young. 1992. Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum. Antimicrob. Agents Chemother. 36:704-711.
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 704-711
-
-
Rathod, P.K.1
Leffers, N.P.2
Young, R.D.3
-
31
-
-
0028295332
-
Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase
-
Rathod, P. K., and S. Reshmi. 1994. Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase. Antimicrob. Agents Chemother. 38:476-480.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 476-480
-
-
Rathod, P.K.1
Reshmi, S.2
-
32
-
-
0012395179
-
Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: Its mechanism of action and inhibition by fluorinated nucleotides
-
Reyes, P., and C. Heidelberger. 1965. Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides. Mol. Pharmacol. 1:14-30.
-
(1965)
Mol. Pharmacol.
, vol.1
, pp. 14-30
-
-
Reyes, P.1
Heidelberger, C.2
-
33
-
-
0020136030
-
Activities of purine and pyrimidine metabolizing enzymes of the human malarial parasite. Plasmodium falciparum
-
Reyes, P., P. K. Rathod, D. J. Sanchez, J. E. K. Mrema, K. H. Riekman, and H.-G. Heidrich. 1982. Activities of purine and pyrimidine metabolizing enzymes of the human malarial parasite. Plasmodium falciparum. Mol. Biochem. Parasitol. 5:275-290.
-
(1982)
Mol. Biochem. Parasitol.
, vol.5
, pp. 275-290
-
-
Reyes, P.1
Rathod, P.K.2
Sanchez, D.J.3
Mrema, J.E.K.4
Riekman, K.H.5
Heidrich, H.-G.6
-
34
-
-
0013965282
-
An isotopic assay for thymidylate synthetase
-
Roberts, D. 1966. An isotopic assay for thymidylate synthetase. Biochemistry 5:3546-3548.
-
(1966)
Biochemistry
, vol.5
, pp. 3546-3548
-
-
Roberts, D.1
-
35
-
-
0345508847
-
Inhibition of thymidylate synthase: Mechanism, methods, and metabolic consequences
-
A. C. Sartorelli, J. S. Lazo, and J. R. Bertino (ed.), Academic Press, Inc., New York
-
Santi, D. V. 1981. Inhibition of thymidylate synthase: mechanism, methods, and metabolic consequences, p. 285-300. In A. C. Sartorelli, J. S. Lazo, and J. R. Bertino (ed.), Molecular actions and targets for cancer chemotherapeutic agents. Academic Press, Inc., New York.
-
(1981)
Molecular Actions and Targets for Cancer Chemotherapeutic Agents
, pp. 285-300
-
-
Santi, D.V.1
-
36
-
-
0015947608
-
A filter assay for thymidylate synthetase using 5-fluoro-2′-deoxyuridylate as an active site titrant
-
Santi, D. V., C. S. McHenry, and E. R. Perriard. 1974. A filter assay for thymidylate synthetase using 5-fluoro-2′-deoxyuridylate as an active site titrant. Biochemistry 13:467-470.
-
(1974)
Biochemistry
, vol.13
, pp. 467-470
-
-
Santi, D.V.1
McHenry, C.S.2
Perriard, E.R.3
-
37
-
-
0018633747
-
Biochemistry of Plasmodium (malarial parasites)
-
Sherman, I. W. 1979. Biochemistry of Plasmodium (malarial parasites). Microbiol. Rev. 43:453-495.
-
(1979)
Microbiol. Rev.
, vol.43
, pp. 453-495
-
-
Sherman, I.W.1
-
38
-
-
0025605441
-
Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum
-
Sirawaraporn, W., R. Sirawaraporn, A. F. Cowman, Y. Yuthavong, and D. V. Santi, 1990. Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry 29:10779-10785.
-
(1990)
Biochemistry
, vol.29
, pp. 10779-10785
-
-
Sirawaraporn, W.1
Sirawaraporn, R.2
Cowman, A.F.3
Yuthavong, Y.4
Santi, D.V.5
-
39
-
-
0017311840
-
Human malaria parasites in continuous culture
-
Trager, W., and J. B. Jensen. 1978. Human malaria parasites in continuous culture. Science 193:673-675.
-
(1978)
Science
, vol.193
, pp. 673-675
-
-
Trager, W.1
Jensen, J.B.2
-
40
-
-
0026519367
-
Kinetic characteristics of ICI D1694: A quinazoline antifolate which inhibits thymidylate synthase
-
Ward, W. H. J., R. Kimbell, and A. L. Jackman. 1992. Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase. Biochem. Pharmacol. 43:2029-2031.
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 2029-2031
-
-
Ward, W.H.J.1
Kimbell, R.2
Jackman, A.L.3
-
41
-
-
0023655202
-
Deoxyribonucleoside triphosphate imbalance, 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death
-
Yoshioka, A., S. Tanaka, O. Hiraoka, Y. Koyama, Y. Hirota, D. Ayusawa, T. Seno, C. Garrett, and Y. Wataya. 1987. Deoxyribonucleoside triphosphate imbalance, 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J. Biol. Chem. 262: 8235-8241.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 8235-8241
-
-
Yoshioka, A.1
Tanaka, S.2
Hiraoka, O.3
Koyama, Y.4
Hirota, Y.5
Ayusawa, D.6
Seno, T.7
Garrett, C.8
Wataya, Y.9
-
42
-
-
0027233039
-
Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate
-
Young, R. D., and P. K. Rathod. 1993. Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate. Antimicrob. Agents Chemother. 37:1102-1107.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1102-1107
-
-
Young, R.D.1
Rathod, P.K.2
-
43
-
-
0024460302
-
Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum
-
Zolg, J. W., J. R. Plitt, G.-X. Chen, and S. Palmer. 1989. Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum. Mol. Biochem. Parasitol. 36:253-262.
-
(1989)
Mol. Biochem. Parasitol.
, vol.36
, pp. 253-262
-
-
Zolg, J.W.1
Plitt, J.R.2
Chen, G.-X.3
Palmer, S.4
|