Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

Oncogene

Volumn 24, Issue 29, 2005, Pages 4701-4709

  Sun, Jiazhi ^a,b   Wang, De An ^a,b   Jain, Rishi K ^c   Carie, Adam ^a,b   Paquette, Steve ^a,b   Ennis, Eileen ^c   Blaskovich, Michelle A ^a   Baldini, Laura ^c   Coppola, Domenico ^b   Hamilton, Andrew D ^c   Sebti, Saïd M ^a,b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Angiogenesis inhibitors; Growth factor binders; PDGF; Tumorigenesis; VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; CALIXARENE; GFB 201; GFB 202; GFB 203; GFB 204; GFB 205; GFB 206; GFB 207; GFB 208; GFB 209; GFB 210; GFB 211; GFB 212; GFB 213; GFB 214; GFB 215; GFB 216; GFB 217; GFB 218; GFB 219; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; STAT3 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CAPILLARY; CELL MIGRATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BLOCKING;

ANIMALS; CALIXARENES; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 22744445537     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208391     Document Type: Article

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