Will it be steroids for ever?

Clinical and Experimental Allergy

Volumn 35, Issue 7, 2005, Pages 843-845

  Barnes, P J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; GLUCOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; NEW DRUG;

ALLERGIC DISEASE; ANTIINFLAMMATORY ACTIVITY; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CORTICOSTEROID THERAPY; DOSE RESPONSE; DRUG DNA BINDING; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SAFETY; HUMAN; INFLAMMATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; SIDE EFFECT; SIGNAL TRANSDUCTION;

ADRENAL CORTEX HORMONES; ANTI-INFLAMMATORY AGENTS; ASTHMA; DNA; DRUG RESISTANCE; GENES; HISTONE DEACETYLASES; HUMANS; HYPERSENSITIVITY; RECEPTORS, GLUCOCORTICOID; REPRESSOR PROTEINS;

EID: 22744434231     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2005.02292.x     Document Type: Short Survey

References (17)

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2. Barnes PJ, Adcock IM, Ito K. Histone acetylation: an important role in inflammatory lung diseases. Eur Respir Dis 2005;25: 552-63.
3. Barnes PJ, Adcock IM. How do corticosteroids work in asthma? Ann Intern Med 2003; 139:359-70.
4. Ito K, Barnes PJ, Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits IL-1b-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 2000; 20: 6891-903.
5. Schacke H, Schottelius A, Docke WD et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc Natl Acad Sci USA 2004; 101:227-32.
6. Bledsoe RK, Montana VG, Stanley TB et al. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell 2002; 110:93-105.
7. Barnes PJ. New drugs for asthma. Nat Rev Drug Discov 2004; 3:831-44.
8. Adcock IM, Lane SJ. Corticosteroid-insensitive asthma: molecular mechanisms. J Endocrinol 2003; 178:347-55.
9. Irusen E, Matthews JG, Takahashi A, Barnes PJ, Chung KF, Adcock IM. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol 2002; 109: 649-57.
10. Matthews JG, Ito K, Barnes PJ, Adcock IM. Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 2004; 113:1100-8.
11. Barnes PJ, Ito K, Adcock IM. A mechanism of corticosteroid resistance in COPD: inactivation of histone deacetylase. Lancet 2004; 363:731-3.
12. Ito K, Tomita T, Barnes PJ, Adcock IM. Oxidative stress reduces histone deacetylase (HDAC)2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun 2004; 315:240-5.
13. Hansel TT, Kharitonov SA, Donnelly LE et al. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J 2003; 17:1298-300.
14. Ito K, Lim S, Caramori G et al. A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA 2002; 99:8921-6.
15. Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, Barnes PJ. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 2004; 200: 689-95.
16. Barnes PJ, Hansel TT. Prospects for new drugs for chronic obstructive pulmonary disease. Lancet 2004; 364:985-96.
17. 2-agonists and corticosteroids. Eur Respir J 2002; 19:182-91.