Bacterial cell wall components as immunomodulators - I. Lipopeptides as adjuvants for parenteral and oral immunization

International Journal of Immunopharmacology

Volumn 19, Issue 9-10, 1997, Pages 547-550

  Bessler, W G ^a   Heinevetter, L ^b   Wiesmuller K H ^c   Jung, G ^d   Baier, W ^a   Huber, M ^a   Lorenz, A R ^a   Esche, U V D ^a   Mittenbuhler K ^a   Hoffmann, P ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Adjuvants; Immunization; Lipopeptide; Vaccines

Indexed keywords

ANTIGEN; FOOT AND MOUTH DISEASE VACCINE; HAPTEN; IMMUNOLOGICAL ADJUVANT; LIPOPEPTIDE; SALMONELLOSIS VACCINE; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIAL CELL WALL; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; DRUG CONJUGATION; FOOT AND MOUTH DISEASE; GRAM NEGATIVE BACTERIUM; GUINEA PIG; IMMUNIZATION; IMMUNOMODULATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARENTERAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SALMONELLOSIS;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; ANTIGENS; BACTERIAL VACCINES; CELL WALL; EPITOPES, T-LYMPHOCYTE; FOOT-AND-MOUTH DISEASE; FREUND'S ADJUVANT; GRAM-NEGATIVE BACTERIA; GUINEA PIGS; IMMUNIZATION; MICE; OLIGOPEPTIDES; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; VIRAL VACCINES; VIRUS DISEASES;

EID: 17944402056     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(97)00054-4     Document Type: Conference Paper

References (15)

1. Bessler, W. G., Baier, W., v. d., Esche, U., Hoffmann, P., Heinevetter, L., Wiesmüller, K.-H. & Jung, G. (1997) Bacterial lipopeptides constitute efficient novel immunogens and adjuvants in parenteral and oral immunization. Behring Inst. Mitt., 98, 390-399.
2. Bessler, W. G., Kleine, B., Biesert, L., Schlecht, S. D., Wiesmüller, K.-H., Metzger, J. & Jung, G. (1990). Bacterial Surface Components as Immunomodulators. In Immunotherapeutic Prospects of Infectious Deseases (eds Masihi, K. N. and Lange, W.), pp. 37-48. Springer Verlag, Berlin.
3. Böltz, T., Jung, G., Wiesmüller, K.-H., Metzger. L. & Bessler, W. G. (1988). Enhancement of the immune response using a synthetic B-lymphocyte mitogen covalently linked to antigens. In Lymphocyte Activation and Differentiation (eds Mani, J. and Dornang, J.), pp. 379-382. Walter de Gruyter, Berlin.
4. Deres, K., Schild, H., Wiesmüller, K. -H., Jung, G. & Rammensee, H. G. (1989) In vivo priming of virus-specific cytotoxic T-lymphocytes with synthetic lipopeptide vaccine. Nature, 342, 561-564.
5. Hoffmann, P., Jiménez-Diaz, M., Loleit, M., Tröger, W., Wiesmüller, K.-H., Metzger, J., Jung, G., Kaiser, L, Stöcklin, I., Lenzner, S., Peters, J. H., Grimm, R., Schäfer, E. & Bessler, W. G. (1990). Preparation of human and murine monoclonal antibodies: antigens combined with or conjugated to lipopeptides constitute potent immunogens for in vitro and in vivo immunizations. Hum. Antibod. Hybridomas, 1, 137-144.
6. h)-cell epitope. FEMS Immunol. Med Microbiol., 17, 225-234.
7. 3CSS induce in vivo B and T helper cell responses to HIV-1 reverse transcriptase. Immunobiology, 195, 61-76.
8. Loleit, M., Tröger, W., Wiesmüller, K. -H., Jung, G., Strecker, M. & Bessler, W. G. (1990) Conjugates of synthetic lymphocyte-activating lipopeptides with segments from HIV proteins induce protein-specific antibody formation. Biol. Chem. Hoppe-Seyler, 371, 967-975.
9. Muller, C. P., Bühring, H. J., Becker, G., Jung, C. C., Jung, G., Tröger, W., Saalmüller, A., Wiesmüller, K. H. & Bessler, W. G. (1989) Specific antibody response towards predicted epitopes of the epeidermal growth factor receptor induced by a thermostable synthetic peptide adjuvant conjugate. Clin. Exp. Immunol., 78, 499-504.
10. Reitermann, A., Metzger, J., Wiesmüller, K. -H., Jung, G. & Bessler, W. G. (1989) Lipopeptide derivatives of bacterial lipoprotein constitute potent immune adjuvants combined with or covalently coupled to antigen or hapten. Biochem. Hoppe-Seyler, 370, 343-352.
11. Schlecht, S., Wiesmüller, K. -H., Jung, G. & Bessler, W. G. (1993) Lipopeptide als natürliche Adjuvantien für Impfstoffe aus Gram-negativen Bakterien. Naturwissenschaften, 80, 9-17.
12. 3C) conjugates. Pathol., 164, 265-271.
13. Wiesmüller, K. H., Bessler, W. G. & Jung, G. (1983) Synthesis of the mitogenic S-(2,3-bis(palmitoloxy)propyl)-N-palmitoyl pentapeptide from the Escherichia coli lipoprotein. Hoppe Seyler's Z Physiol. Chem., 364, 593-606.
14. Wiesmüller, K. -H., Bessler, W. G. & Jung, G. (1992) Solid phase peptide synthesis of lipopeptide vaccines eliciting epitope-specific B-, T-helper and T-killer cell response. Int. J Peptide Protein Res., 40, 255-260.
15. Wiesmüller, K.-H., Metzger, J., Schaude, R., Beck, A., Hess, G., Haas, B., Bessler, W. G. & Jung G. (1990). Synthetic low-molecular weight foot-and-mouth disease virus vaccine and novel lipopeptides for the synthesis of immunogenic lipopeptide-of lipopeptide vaccines eliciting epitope-specific B-, T-helper and T antigen conjugates. Innovation and Perspectives in Solid Phase Synthesis; First International Symposium (R. Epton Hrsg), SPCC (UK) Ltd, Birmingham, pp. 601-607.