Synthetic bacterial lipopeptide analogs facilitate naive CD4+ T cell differentiation and enhance antigen-specific HLA-II-restricted responses

European Journal of Immunology

Volumn 35, Issue 8, 2005, Pages 2434-2442

  Ghielmetti, Mascia ^a   Zwicker, Marianne ^a   Ghielmetti, Tanja ^b   Simon, Markus M ^c   Villiger, Peter M ^a   Padovan, Elisabetta ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Universitats Frauenklinik   (Switzerland)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Adjuvant; Antigen; CD4; Lipopeptide; T cell differentiation

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; IMMUNOLOGICAL ADJUVANT; LIPOPEPTIDE; PADGEM PROTEIN; TETANUS TOXOID;

ANTIGEN SPECIFICITY; ANTIGENICITY; ARTICLE; BORRELIA BURGDORFERI; CELL CULTURE; CELL KINETICS; CONTROLLED STUDY; COVALENT BOND; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG STRUCTURE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; PALMITOYLATION; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADJUVANTS, IMMUNOLOGIC; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; EPITOPES, T-LYMPHOCYTE; G0 PHASE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOGLOBULINS; KINETICS; LIPOPROTEINS; PEPTIDES;

EID: 22644447190     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200526241     Document Type: Article

References (29)

1. Pardoll, D. M., Spinning molecular immunology into successful immunotherapy. Nat. Rev. Immunol. 2002. 2: 227-238.
2. Zinkernagel, R. M., On natural and artificial vaccinations. Annu. Rev. Immunol. 2003. 21: 515-546.
3. Zajac, P., Oertli, D., Marti, W., Adamina, M., Bolli, M., Güller, U., Noppen, C. et al., Phase I/II clinical trial of a nonreplicative vaccinia virus expressing multiple HLA-A0201-restricted tumor-associated epitopes and costimulatory molecules in metastatic melanoma patients. Hum. Gene Ther. 2003. 14: 1497-1510.
4. Pashine, A., Valiante, N. M. and Ulmer, J. B., Targeting the innate immune response with improved vaccine adjuvants. Nat. Med. 2005. 11: S63-S68.
5. Wiesmueller, K. H., Fleckenstein, B. and Jung, G., Peptide vaccines and peptide libraries. Biol. Chem. 2001. 382: 571-579.
6. Zhu, X., Ramos, T. V., Gras-Masse, H., Kaplan, B. E. and BenMohamed, L., Lipopeptide epitopes extended by an N epsilon-palmitoyl-lysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity. Eur. J. Immunol. 2004. 34: 3102-3114.
7. Vitiello, A., Ishioka, G., Grey, H. M., Rose, R., Farness, P., LaFond, R., Yuan, L. et al., Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans. J. Clin. Invest. 1995. 95: 341-349.
8. Deres, K., Schild, H., Wiesmuller, K. H., Jung, G. and Rammensee, H. G., In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine. Nature 1989. 342: 561-564.
9. Bessler, W. G. and Jung, G., Synthetic lipopeptides as novel adjuvants. Res. Immunol. 1992. 143: 548-553.
10. Wiedemann, F., Link, R., Pumpe, K., Jacobshagen, U., Schaefer, H. E., Wiesmuller, K. H., Hummel, R. P. et al., Histopathological studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates. J. Pathol. 1991. 164: 267-271.
11. Huber, M., Baier, W., Bessler, W. G. and Heinevetter, L., Modulation of the Th1/Th2 bias by lipopeptide and saponin adjuvants in orally immunized mice. Immunobiology 2002. 205: 61-73.
12. + T lymphocytes. Eur. J. Immunol. 2003. 33: 2044-2052.
13. 4 lipopeptide does not impair antigen up-take by human dendritic cells. Immunology, Medimond International Proceeding 2004, pp 321-325.
14. Hertz, C. J., Kiertscher, S. M., Godowski, P. J., Bouis, D. A., Norgard, M. V., Roth, M. D. and Modlin, R. L., Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J. Immunol. 2001. 166: 2444-2450.
15. Caux, C., Vanbervliet, B., Massacrier, C., Azuma, M., Okumura, K., Lanier, L. L. and Banchereau, J., B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 1994. 180: 1841-1847.
16. Sallusto, F., Lening, D., Förster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
17. + T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur. J. Immunol. 2003. 33: 474-482.
18. Kapsenberg, M., Dendritic-cell control of pathogen-driven T-cell polarization. Nat. Rev. Immunol. 2003. 3: 984-993.
19. Sieling, P. A., Chung, W., Duong, B. T., Godowski, P. J., Modlin, R. L., Toll-like receptor 2 ligands as adjuvants for human Th1 responses. J. Immunol. 2003. 170: 194-200.
20. Gern, L., Capiau, C., Hauser, P., Lobet, Y., Simoen, E., Voet, P. and Petre, J., Immunization of mice by recombinant OspA preparations and protection against Borrelia burgdorferi infection induced by Ixodes ricinustick bites. Immunol. Lett. 1994. 39: 249-258.
21. Wallich, R., Siebers, A., Jahraus, O., Brenner, C., Stehle, T. and Simon, M. M., DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce protective antibodies suitable for prophylaxis but not for resolution of Lyme disease. Infect. Immun. 2001. 69: 2130-2136.
22. Altenschmidt, U., Riccardi-Castagnoli, P., Modolell, M., Otto, H., Wiesmueller, K. H., Jung, G. and Simon, M. M., Bone marrow-derived macrophage lines and immortalized cloned macrophage and dendritic cells support priming of Borrelia burgdorferi-specific T cell responses in vitro and/or in vivo. Immunol. Lett. 1996. 50: 41-49.
23. Demotz, S., Barbey, C., Corradin, G., Amoroso, A. and Lanzavecchia, A., The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86. Eur. J. Immunol. 1993. 23: 425-432.
24. Alexander, J., Del Guercio, M. F., Maewal, A., Qiao, L., Fikes, J. R., Chesnut, W., Paulson, J. et al., Linear PADRE T helper epitope and carbohydrate B cell epitope conjugate induce specific high titer IgG antibody responses. J. Immunol. 2000. 164: 1625-1633.
25. + effector and memory T cell generation. Nat. Immunol. 2003. 4: 835-842.
26. Sallusto, F., Geginat, J. and Lanzavecchia, A., Central memory and effector memory T cell subsets: Function, generation, and maitenance. Annu. Rev. Immunol. 2004. 22: 745-763.
27. Komai-Koma, M., Jones, L., Ogg, G. S., Xu, D. and Liew, F. Y., TLR2 is expressed on activated T cells as a costimulatory receptor. Proc. Natl. Acad. Sci. USA 2004. 101: 3029-3034.
28. Sobek, V., Birkner, N., Falk, I., Würch, A., Kirschning, C. J., Wagner, H., Wallich, R., Lamers, M. C. and Simon, M. M., Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease. Arthritis Res. Ther. 2004. 6: 433-446.
29. Sallusto, F. and Lanzavecchia, A., Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1994. 179: 1109-1118.