Characterization of hemodynamic events following intravascular infusion of recombinant adenovirus reveals possible solutions for mitigating cardiovascular responses

Molecular Therapy

Volumn 12, Issue 2, 2005, Pages 254-263

  Machemer, Todd ^a   Engler, Heidrun ^a   Tsai, Van ^a   Lee, Seoju ^a   Cannon Carlson, Susan ^a   Voloch, Marcio ^a   Schluep, Thomas ^a   Ravindran, Sundari ^a   Vellekamp, Gary ^a   Brin, Elena ^a   Cornell, Douglas ^a   Sutjipto, Suganto ^a   Wen, Shu Fen ^a   Horn, Mark ^a   Van Rooijen, Nico ^b   Maneval, Dan ^a   Hutchins, Beth ^a   LaFace, Drake ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Bradycardia; Cardiovascular response; Electrocardiogram analysis; Hemodynamics; Intravascular; Kupffer cells; Neutralizing antibody; Recombinant adenovirus; SA node block; Tachyphylaxis

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; NEUTRALIZING ANTIBODY; PROBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BRADYCARDIA; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; DRUG ADMINISTRATION ROUTE; DRUG INFUSION; DRUG SAFETY; ELECTROCARDIOGRAM; HEART HEMODYNAMICS; HUMAN; HUMAN CELL; HYPOTENSION; HYPOTHERMIA; INTRAVASCULAR INFUSION; KUPFFER CELL; MOUSE; NONHUMAN; RETICULOENDOTHELIAL SYSTEM; SINUS NODE; TACHYPHYLAXIS; TELEMETRY; VIRAL GENE DELIVERY SYSTEM; VIRUS CELL INTERACTION; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; BLOOD PRESSURE; CARCINOMA, NON-SMALL-CELL LUNG; CARDIAC OUTPUT; CARDIOVASCULAR SYSTEM; ELECTROCARDIOGRAPHY; GENE THERAPY; GENETIC VECTORS; HEART RATE; HUMANS; INFLUENZA A VIRUS; KUPFFER CELLS; MICE; MICE, INBRED BALB C;

ADENOVIRIDAE; MURINAE;

EID: 22644437160     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.03.007     Document Type: Article

References (34)

1. H. Ben-Gary R.L. McKinney T. Rosengart M.L. Lesser and R.G. Crystal Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes Mol. Ther. 6 2002 287-297
2. G. Cichon et al. Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits J. Gene Med. 1 1999 360-371
3. A. Lieber et al. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors J. Virol. 71 1997 8798-8807
4. J.N. Lozier et al. Toxicity of a first-generation adenoviral vector in rhesus macaques Hum. Gene Ther. 13 2002 113-124
5. N. Morral et al. Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons Hum. Gene Ther. 13 2002 143-154
6. D.A. Muruve M.J. Barnes I.E. Stillman and T.A. Libermann Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo Hum. Gene Ther. 10 1999 965-976
7. S.E. Raper et al. A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency Hum. Gene Ther. 13 2002 163-175
8. T. Reid R. Warren and D. Kirn Intravascular adenoviral agents in cancer patients: Lessons from clinical trials Cancer Gene Ther. 9 2002 979-986
9. T. Reid et al. Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints Cancer Res. 62 2002 6070-6079
10. M.A. Schnell et al. Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors Mol. Ther. 3 2001 708-722
11. Y. Zhang et al. Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages Mol. Ther. 3 2001 697-707
12. S.E. Raper et al. Fatal systemic inflammatory response syndrome in an ornithine transcarbamylase deficient patient following adenoviral gene transfer Mol. Genet. Metab. 80 2003 148-158
13. W.K. O'Neal et al. Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing alpha1-antitrypsin after systemic delivery Hum. Gene Ther. 9 1998 1587-1598
14. A.N. Varnavski et al. Preexisting immunity to adenovirus in rhesus monkeys fails to prevent vector-induced toxicity J. Virol. 76 2002 5711-5719
15. Q. Liu et al. The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors Hum. Gene Ther. 14 2003 627-643
16. J.N. Lozier M.E. Metzger R.E. Donahue and R.A. Morgan Adenovirus-mediated expression of human coagulation factor IX in the rhesus macaque is associated with dose-limiting toxicity Blood 94 1999 3968-3975
17. J.N. Higginbotham P. Seth R.M. Blaese and W.J. Ramsey The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid Hum. Gene Ther. 13 2002 129-141
18. G. Wolff S. Worgall N. van Rooijen W.R. Song B.G. Harvey and R.G. Crystal Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ J. Virol. 71 1997 624-629
19. A.K. Zaiss Q. Liu G.P. Bowen N.C. Wong J.S. Bartlett and D.A. Muruve Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors J. Virol. 76 2002 4580-4590
20. D. Rea et al. Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset J. Virol. 73 1999 10245-10253
21. A. Oberholzer et al. Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells J. Immunol. 168 2002 3412-3418
22. G. Schiedner et al. A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells Hum. Gene Ther. 14 2003 1631-1641
23. A. Rahman et al. Specific depletion of human anti-adenovirus antibodies facilitates transduction in an in vivo model for systemic gene therapy Mol. Ther. 3 2001 768-778
24. E.J. Whalen A.K. Johnson and S.J. Lewis Functional evidence for the rapid desensitization of 5-HT(3) receptors on vagal afferents mediating the Bezold-Jarisch reflex Brain Res. 873 2000 302-305
25. E.J. Whalen A.K. Johnson and S.J. Lewis Beta-adrenoceptor dysfunction after inhibition of NO synthesis: Functional evidence for the rapid desensitization of 5-HT(3) receptors on vagal afferents mediating the Bezold-Jarisch reflex Hypertension 36 2000 376-382
26. M.D. Travis E.J. Whalen and S.J. Lewis Heterologous desensitization of beta-adrenoceptor signal transduction in vivo Eur. J. Pharmacol. 328 1997 R1-R3
27. J.J. Lopez et al. Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response Am. J. Physiol. 273 1997 H1317-H1323
28. J.K. Donahue et al. Focal modification of electrical conduction in the heart by viral gene transfer Nat. Med. 6 2000 1395-1398
29. R. Morrissey C.E.A.S. Horvath J.N.C. Patrick E. Evans and J. MacDonald Porcine toxicology studies of SCH 58500, an adenoviral vector for the p53 gene Toxicol. Sci. 65 2002 256-265
30. B.G. Huyghe et al. Purification of a type 5 recombinant adenovirus encoding human p53 by column chromatography Hum. Gene Ther. 6 1995 1403-1416
31. P.W. Shabram et al. Analytical anion-exchange HPLC of recombinant type-5 adenoviral particles Hum. Gene Ther. 8 1997 453-465
32. P. Shabram and E. Aguilar-Cordova Multiplicity of infection/multiplicity of confusion Mol. Ther. 2 2000 420-421
33. G. Vellekamp et al. Empty capsids in column-purified recombinant adenovirus preparations Hum. Gene Ther. 12 2001 1923-1936
34. N. Van Rooijen and A. Sanders Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes and applications J. Immunol. Methods 174 1994 83-93