A new platform for oligonucleotide delivery utilizing the PEG prodrug approach

Bioconjugate Chemistry

Volumn 16, Issue 4, 2005, Pages 758-766

  Zhao, Hong ^a   Greenwald, Richard B ^a   Reddy, Prasanna ^a   Xia, Jing ^a   Peng, Ping ^a  

^a Enzon Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMA STABILITY;

AREAS UNDER THE CURVES; DIHYDROPYRAN; ENHANCED STABILITY; HALF LIVES; IN-VITRO; PRODRUGS; PROTECTING GROUP; RAT PLASMA; SOLID-STATE SYNTHESIS;

OLIGONUCLEOTIDES;

ALCOHOL; MACROGOL; NUCLEASE; OBLIMERSEN; OLIGONUCLEOTIDE; PRODRUG; PYRAN DERIVATIVE;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CHEMICAL MODIFICATION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; SOLID STATE;

MAMMALIA;

EID: 22644432989     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc049804k     Document Type: Article

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