Metallothionein-enriched hepatocytes are resistant to ferric nitriloacetate toxicity during conditions of glutathione depletion

Toxicology Letters

Volumn 158, Issue 2, 2005, Pages 108-115

  Min, Kyong Son ^a   Tanaka, Naoko ^a   Horie, Taeko ^a   Kawano, Hiroko ^a   Tetsuchikawahara, Noriko ^a   Onosaka, Satomi ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Hydroxyl radical scavenger; Metallothionein; Oxidative damage; Secondary antioxidant

Indexed keywords

ANTIOXIDANT; CADMIUM; CHELATING AGENT; FERRIC NITRILOACETATE; GLUTATHIONE; METALLOTHIONEIN; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL PROTECTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; CARCINOGENS; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRIC COMPOUNDS; FREE RADICAL SCAVENGERS; GLUTATHIONE; HEPATOCYTES; L-LACTATE DEHYDROGENASE; MALE; METALLOTHIONEIN; NITRILOTRIACETIC ACID; RATS; RATS, WISTAR;

EID: 22544485060     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.03.001     Document Type: Article

References (32)

1. G.K. Andrews Regulation of metallothionein gene expression by oxidative stress and metal ions Biochem. Pharmacol. 59 2000 95 104
2. M. Awai Intraperitoneal injection of a chelate iron complex salt causes diabetes in rat and rabbits Nippon Ketsueki Gakkai Zasshi 41 1978 1293 1300
3. L. Cai, and M.G. Cherian Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium- metallothioneins Toxicol. Lett. 136 2003 193 198
4. C.C. Conrad, D.T. Grabowski, C.A. Walter, M. Sabia, and A. Richardson Using MT(-/-) mice to study metallothionein and oxidative stress Free Radic. Biol. Med. 28 2000 447 462
5. S.R. Davis, D.A. Samuelson, and R.J. Cousins Metallothionein expression protects against carbon tetrachloride-induced hepatotoxicity, but overexpression and dietary zinc supplementation provide no further protection in metallothionein transgenic and knockout mice J. Nutr. 131 2001 215 222
6. B. Halliwell, and J.M. Gutteridge Role of free radicals and catalytic metal ions in human disease: an overview Methods Enzymol. 186 1990 1 85
7. S. Inoue, and S. Kawanishi Hydroxyl radical production and human DNA damage induced by ferric nitrilotriacetate and hydrogen peroxide Cancer Res. 47 1987 6522 6527
8. B. Kaina, H. Lohrer, M. Karin, and P. Herrlich Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents Proc. Natl. Acad. Sci. U.S.A. 87 1990 2710 2714
9. Y.J. Kang, Y. Chen, A. Yu, M. Voss-McCowan, and P.N. Epstein Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity J. Clin. Invest. 100 1997 1501 1506
10. Y.J. Kang, G. Li, and J.T. Saari Metallothionein inhibits ischemia-reperfusion injury in mouse heart Am. J. Physiol. 276 1999 993 997
11. Y.J. Kang The antioxidant function of metallothionein in the heart Proc. Soc. Exp. Biol. Med. 222 1999 263 273
12. M.V. Kumari, M. Hiramatsu, and M. Ebadi Free radical scavenging actions of metallothionein isoforms I and II Free Radic. Res. 29 1998 93 101
13. J.S. Lazo, Y. Kondo, D. Dellapiazza, A.E. Michalska, K.H. Choo, and B.R. Pitt Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes J. Biol. Chem. 270 1995 5506 5510
14. X. Li, H. Chen, and P.N. Epstein Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species J. Biol. Chem. 279 2004 765 771
15. J.L. Li, S. Okada, S. Hamazaki, Y. Ebina, and O. Midorikawa Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate Cancer Res. 47 1987 1867 1869
16. J. Liu, B.F. Kimler, Y. Liu, and C.D. Klaassen Metallothionein-I transgenic mice are not protected from gamma-radiation Toxicol. Lett. 104 1999 183 187
17. J. Liu, Y. Liu, D. Hartley, C.D. Klaassen, S.E. Shehin-Johnson, A. Lucas, and S.D. Cohen Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity J. Pharmacol. Exp. Ther. 289 1999 580 586
18. K.S. Min, F. Morishita, N. Tetsuchikawahara, and S. Onosaka Induction of hepatic and renal metallothionein synthesis by ferric nitrilotriacetate in mice: the role of MT as an antioxidant Toxicol. Appl. Pharmcol. 204 2005 9 17
19. K.S. Min, K. Nishida, and S. Onosaka Protective effect of metallothionein to ras DNA damage induced by hydrogen peroxide and ferric ion-nitrilotriacetic acid Chem. Biol. Interact. 122 1999 137 152
20. K.S. Min, Y. Terano, S. Onosaka, and K. Tanaka Induction of metallothionein synthesis by menadione or carbon tetrachloride is independent of free radical production Toxicol. Appl. Pharmacol. 113 1992 74 79
21. I. Nakagawa, M. Suzuki, N. Imura, and A. Naganuma Involvement of oxidative stress in paraquat-induced metallothionein synthesis under glutathione depletion Free Radic. Biol. Med. 24 1998 1390 1395
22. S. Onosaka, and M.G. Cherian Comparison of metallothionein determination by polarographic and cadmium-saturation methods Toxicol. Appl. Pharmacol. 63 1982 270 274
23. M.J. Perez, and A.I. Cederbaum Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity Free Radic. Biol. Med. 34 2003 443 455
24. D.J. Reed, J.R. Babson, P.W. Beatty, A.E. Brodie, W.W. Ellis, and D.W. Potter High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides Anal. Biochem. 106 1980 55 62
25. M. Sato Dose-dependent increases in metallothionein synthesis in the lung and liver of paraquat-treated rats Toxicol. Appl. Pharmacol. 107 1991 98 105
26. N. Shiraishi, H. Yamamoto, Y. Takeda, S. Kondoh, H. Hayashi, K. Hashimoto, and K. Aono Increased metallothionein content in rat liver and kidney following X-irradiation Toxicol. Appl. Pharmacol. 85 1986 128 134
27. K. Tanaka, M. Sato, Y. Tomita, and A. Ichihara Biochemical studies on liver functions in primary cultured hepatocytes of adult rats. Part I: hormonal effects on cell viability and protein synthesis J. Biochem. (Tokyo) 84 1978 937 946
28. P.J. Thornalley, and M. Vasak Possible role for metallothionein in protection against radiation-induced oxidative stress: kinetics and mechanism of its reaction with superoxide and hydroxyl radicals Biochim. Biophys. Acta 827 1985 36 44
29. M. Webb Functions of hepatic and renal metallothioneins in the control of the metabolism of cadmium and certain other bivalent cations Exp. Suppl. 34 1979 313 320
30. H. Zheng, J. Liu, Y. Liu, and C.D. Klaassen Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity Toxicol. Lett. 87 1996 139 145
31. Z. Zhou, X. Sun, and Y.Z. Kang Metallothionein protection against alcoholic liver injury through inhibition of oxidative stress Exp. Biol. Med. 227 2002 214 222
32. Z. Zhou, X. Sun, J.C. Lambert, J.T. Saari, and Y.J. Kang Metallothionein-independent zinc protection from alcoholic liver injury Am. J. Pathol. 160 2002 2267 2274