Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex

Biochemical Journal

Volumn 389, Issue 2, 2005, Pages 365-371

  Kumar, Mukesh ^a   Prashar, Vishal ^a   Mahale, Smita ^b   Hosur, Madhusoodan V ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

^b NATIONAL INSTITUTE FOR RESEARCH IN REPRODUCTIVE HEALTH   (India)

Author keywords

Catalysis; HIV 1 protease; Inhibitor; Reaction intermediate; Transition state; X ray crystallography

Indexed keywords

CATALYSIS; COMPLEXATION; CRYSTAL STRUCTURE; DRUG DOSAGE; ENZYME INHIBITION; HYDROGEN BONDS; REACTION KINETICS; SUBSTRATES; X RAY ANALYSIS;

DRUG DESIGN; HIV-1 PROTEASE; REACTION INTERMEDIATES; TRANSITION STATES;

ENZYMES;

HISTIDYLLYSYLALANYLARGINYLVALYLLEUCYLNITROPHENYLALANYLGLUTAMYLALANYLNORLEUCYLSERINE; OLIGOPEPTIDE; PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONFORMATION; CRYSTAL STRUCTURE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; PRIORITY JOURNAL;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HIV PROTEASE; HYDROGEN BONDING; MODELS, MOLECULAR; PEPTIDES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 22544467240     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041804     Document Type: Article

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