Rapid screening for HIV-1 protease inhibitor leads through X-ray diffraction

Acta Crystallographica Section D: Biological Crystallography

Volumn 60, Issue 3, 2004, Pages 594-596

  Pillai, Bindu ^a   Kannan, K K ^a   Bhat, S V ^b   Hosur, M V ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTICOAGULANT AGENT; COUMARIN DERIVATIVE; LIGAND; PEPSTATIN; PROTEINASE; PROTEINASE INHIBITOR; STREPTOMYCES PEPSIN INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; HYDROGEN BOND; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; ANTICOAGULANTS; CATALYTIC DOMAIN; COUMARINS; CRYSTALLOGRAPHY, X-RAY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HYDROGEN BONDING; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PEPSTATINS; PROTEIN STRUCTURE, TERTIARY;

EID: 4644223773     PISSN: 09074449     EISSN: None     Source Type: Journal    
DOI: 10.1107/S0907444903029676     Document Type: Article

References (17)

1. Brünger, A. T., Adams, P. D, Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewki, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T. & Warren, G. L. (1998). Acta Cryst. D54, 905-921.
2. Cheng, Y. E., Yin, F. H., Foundling, S., Blomstrom, D. & Kettner, C. A. (1990). Proc. Natl Acad. Sci. USA, 87, 9660-9664.
3. Dreyer, G. B., Lambert, D. M., Meek, T. D., Carr, T. J., Tomazek, T. A., Fernandez, A. V., Bartus, H., Cacciavillani, E., Hassell, A. M., Minnick, M., Petteway, S. R. & Metcalf, B. W. (1992). Biochemistry, 31, 6646-6659.
4. Erickson, J. W., Neidhart, D. J., Vandrie, J., Kempf, D. J., Wang, X. C., Norbeck, D. W., Plattner, J. J., Rittenhouse, J. W., Turon, M., Wideburgh, N., Kohlbrenner, W. E., Simmer, R., Helfrich, R., Paul, D. A. & Knigge, M. (1990). Science, 249, 527-533.
5. Fitzgerald, P. M. D., McKeever, B. M., Van Middlesworth, J. F., Springer, J. P., Heimbach, J. C., Leu, C. T., Herber, W. K., Dixon, R. A. F. & Darke, P. L. (1990). J. Biol Chem. 265, 14209-14219.
6. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. (1991). Acta Cryst. A47, 110-119.
7. Lapatto, R., Blundell, T., Hemmings, A., Overington, J., Widerspin, A. M., Wood, S., Merson, J. R., Whittle, P. J., Danley, D. E., Geoghegan, K. F., Hawrylik, S. J., Lee, S. E., Scheld, K. & Hobart, P. M. (1989). Nature (London), 342, 299-302.
8. Lunney, E. A., Hagen, S. E., Domagala, J. M., Humblet, C., Kosinski, J., Tait, B. D., Warmus, J. S., Wilson, M., Ferguson, D., Hupe, D., Tummino, P. J., Baldwin, E. T., Bhat, T. N., Liu, B. & Erickson, J. W. (1994). J. Med. Chem. 37, 2664-2677.
9. Munshi, S., Chen, Z., Li, Y., Olsen, D. B., Fraley, M. E., Hungate, R. W. & Kuo, L. C. (1998). Acta Cryst. D54, 1053-1060.
10. Navia, M. A., Fitzgerald, P. M. D., McKeever, B. M., Leu, C. T., Heimbach, J. C., Herber, W. K., Sigal, I. S., Darke, P. L. & Springer, J. P. (1989). Nature (London), 337, 615-620.
11. Otwinowski, Z. (1993). Proceedings of the CCP4 Study Weekend. Data Collection and Processing, edited by L. Sawyer, N. Isaacs & S. Bailey, pp. 56-62. Warrington: Daresbury Laboratory.
12. Pillai, B., Kannan, K. K. & Hosur, M. V. (2001). Proteins Struct. Funct. Genet. 43, 57-64.
13. Spinnelli, S., Liq, Q. Z., Alzari, P. M., Hirel, P. H. & Poljak, R. J. (1991). Biochimie, 73, 1391-1393.
14. Tomasselli, A. G. & Heinrikson, R. L. (2000). Biochim. Biophys. Acta, 1477, 189-214.
15. Wlodawer, A. & Erickson, J. W. (1993). Annu. Rev. Biochem. 62, 543-585.
16. Wlodawer, A., Miller, M., Jaskolski, M., Sathyanarayana, B. K., Baldwin, E., Weber, I. T., Selk, L. M., Clawson, L., Schneider, J. & Kent, S. B. H. (1989). Science, 245, 616-621.
17. Wlodawer, A. & Vondrasek, J. (1998). Annu. Rev. Biophys. Biomol. Struct. 27, 249-284.