Regulatory T Cells in Maintenance and Reversal of Peripheral Tolerance in Vivo

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5284-5289

  Kong, Young Yun ^a,c   Eto, Masatoshi ^b   Omoto, Kazuya ^a   Umesue, Masatoshi ^a   Hashimoto, Asako ^a   Nomoto, Kikuo ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CYTOTOXICITY; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MALE; MOUSE; PASSIVE IMMUNIZATION; REGULATORY T LYMPHOCYTE; SKIN TRANSPLANTATION; T LYMPHOCYTE;

ANIMALS; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; IMMUNE TOLERANCE; IMMUNIZATION, PASSIVE; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SKIN TRANSPLANTATION; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 0030589240     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. + thymocytes. Nature 333:742.
2. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
3. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
4. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
5. Miller, J. F. A. P., and W. R. Heath. 1993. Self-ignorance in the peripheral T-cell pool. Immunol. Rev. 133:131.
6. Bloom, B. R., P. Salgame, and B. Diamond. 1992. Revisiting and revising suppressor T cells. Immunol. Today 13:131.
7. Sercarz, E., and U. Krzych. 1991. The distinctive specificity of antigen-specific suppressor T cells. Immunol. Today 12:111.
8. Qin, S., S. P. Cobbold, H. Pope, J. Elliott, D. Kioussis, J. Davies, and H. Waldmann. 1993. "Infectious" transplantation tolerance. Science 259:974.
9. Miller, A., O. Lider, A. B. Robert, M. B. Sporn, and H. L. Weiner. 1992. Suppressor T cells generated by oral totalization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering. Proc. Natl. Acad. Sci. USA 89:421.
10. Scully, R., S. Qin, S. Cobbold, and H. Waldmann. 1994. Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur. J. Immunol. 24:2383.
11. + T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177:627.
12. + β islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice. J. Exp. Med. 182:87.
13. Lafaille, J. J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78:388.
14. + T cells. J. Exp. Med. 178: 237.
15. Miller, A., O. Lider, and H. L. Weiner. 1991. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med. 174:791.
16. Wildner, G., and S. R. Thurau. 1995. Orally induced bystander suppression in experimental autoimmune uveoretinitis occurs only in the periphery and not in the eye. Eur. J. Immunol. 25:1292.
17. Lombardi, G., S. Sidhu, R. Batchelor, and R. Lechler. 1994. Anergic T cells as suppressor cells in vitro. Science 264:1587.
18. + suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-β. J. Immunol. 146:1163.
19. Mayumi, H., K. Nomoto, and R. A. Good. 1988. A surgical technique for experimental free skin grafting in mice. Jpn. J. Surg. 18:548.
20. + T cells in cyclophosphamide-induced tolerance to H-2-compatible, Mls-disparate antigens. J. Exp. Med. 171:97.
21. Eto, M., H. Mayumi, Y. Tomita, Y. Yoshikai, Y. Nishimura, and K. Nomoto. 1990. Sequential mechanisms of cyclophosphamide-induced skin allograft tolerance including the intrathymic clonal deletion followed by late breakdown of the clonal deletion. J. Immunol. 145:1303.
22. Maeda, T., M. Eto, Y. Nishimura, K. Nomoto, Y.-Y. Kong, and K. Nomoto. 1993. Role of peripheral hemopoietic chimerism in achieving donor-specific tolerance in adult mice. J. Immunol. 150:753.
23. Essery, G., M. Feldmann, and J. R. Lamb. 1988. Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. Immunology 64:413.
24. + T cells in allograft rejection. J. Immunol. 139:4022.
25. Guerder, S., and P. Matinger. 1992. A fail-safe mechanism for maintaining self-tolerance. J. Exp. Med. 176:553.
26. + helper T cells, and reversal of tolerance through introduction of third-party helper T cells. J. Exp. Med. 172:105.
27. Stach, R. M., and D. A. Rowley. 1993. A first or dominant immunization. II. Induced immunoglobulin carries transforming growth factor β and suppresses cytolytic T cell responses to unrelated alloantigens. J. Exp. Med. 178:841.
28. Rosenberg, A. S., T. Mizuochi, S. O. Sharrow, and A. Singer. 1987. Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection. J. Exp. Med. 165:1296.
29. + T cells. J. Exp. Med. 177:1587.
30. Hammerling, G. J., G. Schönrich, I. Ferber, and B. Arnold. 1993. Peripheral tolerance as a multi-step mechanism. Immunol. Rev. 133:93.
31. Morahan, G., J. Allison, and J. F. A. P. Miller. 1989. Tolerance of class I histocompatibility antigens expressed extrathymically. Nature 339:622.
32. a expressing cells. Nature 339:541.
33. + T cells by B7-transfected melanoma cells. Science 259:368.
34. Chen, Y., V. K. Kuchroo, J. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
35. Lehmann, P. V., T. Forsthuber, A. Miller, and E. E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
36. Isobe, M., H. Yagita, K. Okumura, and A. Ihara. 1992. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 255:1125.
37. Lenschow, D. J., Y. Zeng, J. R. Thristlethwaite, A. Montag, W. Brady, M. G. Gibson, P. S. Linsley, and J. A. Bluestone. 1992. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 257:789.
38. Hall, B. M., M. E. Jelbart, and S. E. Dorsch. 1984. Suppressor T cells in rats with prolonged cardiac allograft survival after treatment with cyclosporin A. Transplantation 37:595.
39. Hall, B. M. 1985. Mechanisms maintaining enhancement of allografts. J. Exp. Med. 161:123.
40. Nagao, T., D. J. G. White, and R. Y. Calne. 1982. Kinetics of unresponsiveness induced by a short course of cyclosporin A. Transplantation 33:31.