Porphyrins and porphines bind strongly and specifically to tRNA, precursor tRNA and to M1 RNA and inhibit the ribonuclease P ribozyme reaction

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1730, Issue 1, 2005, Pages 47-55

  Hori, Yoshiaki ^b   Rogert, Maria C ^a   Tanaka, Terumichi ^b   Kikuchi, Yo ^b   Bichenkova, Elena V ^a   Wilton, Amanda N ^a   Gbaj, Abdul ^a   Douglas, Kenneth T ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Fluorescence binding studies; Inhibition kinetics; Ribozyme inhibitors; Transfer RNA

Indexed keywords

BILIRUBIN; CHLOROPHYLL; DEUTEROPORPHYRIN IX; HEMATIN; HEMATOPORPHYRIN; HEMIN; PORPHYRIN DERIVATIVE; PROTOPORPHYRIN; RIBONUCLEASE P; RIBOZYME; RNA PRECURSOR; TETRACARBOXYPHENYLPORPHINE; TETRAKIS(N METHYLPYRIDYL)PORPHINE; TETRAKIS[4 (TRIMETHYLAMMONIO)PHENYL]PORPHINE; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CELL NUCLEUS; COMPLEX FORMATION; DISSOCIATION CONSTANT; DRUG BINDING; DRUG DETERMINATION; DRUG SPECIFICITY; ENVIRONMENT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBUNIT; ESCHERICHIA COLI; EXCITATION; FLAME PHOTOMETRY; FLUORESCENCE SPECTROSCOPY; GENETIC VARIABILITY; LINEAR SYSTEM; PRIORITY JOURNAL; RNA ANALYSIS; RNA BINDING; RNA TRANSLATION;

ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; KINETICS; PORPHYRINS; PROTEIN BINDING; RIBONUCLEASE P; RNA PRECURSORS; RNA, TRANSFER; SPECTROMETRY, FLUORESCENCE;

ESCHERICHIA COLI;

EID: 22444432810     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2005.06.003     Document Type: Article

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