Sequence-specific interaction of U1 snRNA with the SMN complex

EMBO Journal

Volumn 21, Issue 5, 2002, Pages 1188-1196

  Yong, Jeongsik ^a   Pellizzoni, Livio ^a   Dreyfuss, Gideon ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

SMN; snRNP; Spinal muscular atrophy; Stem loop 1; U1 snRNA

Indexed keywords

CELL PROTEIN; SMALL NUCLEAR RNA; SURVIVAL MOTOR NEURON PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BIOGENESIS; CELL SURVIVAL; COMPLEX FORMATION; MICROINJECTION; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA BINDING; RNA SEQUENCE; SEQUENCE HOMOLOGY; SPLICEOSOME; XENOPUS;

ANIMALS; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; HELA CELLS; HUMANS; MACROMOLECULAR SUBSTANCES; METHYLATION; MUTAGENESIS; NERVE TISSUE PROTEINS; NUCLEIC ACID CONFORMATION; OOCYTES; PROTEIN BINDING; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; RNA CAPS; RNA, SMALL NUCLEAR; RNA-BINDING PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

ANIMALIA;

EID: 0036500546     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.5.1188     Document Type: Article

References (51)

1. The conformation of chicken, rat and human U1A RNAs in solution
2. U2 RNA shares a structural domain with U1, U4 and U5 RNAs
3. Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: Implications for spinal muscular atrophy
4. When is a deletion not a deletion? When it is converted
5. Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product and is a component of gems
6. Gemin4: A novel component of the SMN complex that is found in both gems and nucleoli
7. 3G cap in the transport of U1 snRNP to the nucleus
8. 3G cap
9. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis
10. Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)
11. SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets
12. The methylosome: A 20S complex containing JBP1 and pIC1n produces dimethylarginine-modified Sm proteins
13. Gemin5: A novel WD repeat protein component of the SMN complex that binds Sm proteins
14. In vitro assembly of U1 snRNPs
15. Loop I of U1 small nuclear RNA is the only essential RNA sequence for binding of specific UI small nuclear ribonucleoprotein particle proteins
16. The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal
17. Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing
18. Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein
19. A simple and rapid method for generating a deletion by PCR
20. Nuclear export of different classes of RNA is mediated by specific factors
21. Direct interaction of the spinal muscular atrophy disease protein SMN with the small nucleolar RNA-associated protein fibrillarin
22. Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs
23. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
24. Identification and characterization of a spinal muscular atrophy-determining gene
25. A novel nuclear structure containing the survival of motor neurons protein
26. Molecular characterization of the protein products of the fragile X syndrome gene and the survival of motor neurons gene
27. The spinal muscular atrophy disease gene product, SMN and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins
28. The domain encoded by exon 2 of the survival motor neuron protein mediates nucleic acid binding
29. Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding
30. Ribonucleoprotein assembly: Clues from spinal muscular atrophy
31. Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins
32. Nucleocytoplasmic transport and snRNP assembly
33. Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins
34. A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs
35. Spinal muscular atrophy
36. Sequence of U1 RNA from Drosophila melanogaster: Implications for U1 secondary structure and possible involvement in splicing
37. SMN interacts with a novel family of hnRNP and spliceosomal proteins
38. Structure and assembly of the spliceosomal snRNPs. Novartis Medal Lecture
39. The association of the U1-specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins
40. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing
41. SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins
42. The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1
43. A functional interaction between the survival motor neuron complex and RNA polymerase II
44. Purification of native SMN complexes and identification of Gemin6 as a novel component
45. 3G cap hypermethylation of U1 small nuclear ribonucleoprotein (snRNP) in vitro: Evidence that the U1 small nuclear RNA-(guanosine-N2)methyltransferase is a non-snRNP cytoplasmic protein that requires a binding site on the Sm core domain
46. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein
47. A specific 31nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component
48. Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA
49. Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle
50. Direct, sequence-specific binding of the human U1-70K ribonucleoprotein antigen protein to loop I of U1 small nuclear RNA
51. Spliceosomal UsnRNP biogenesis, structure and function