Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection

Journal of Chromatography B: Biomedical Applications

Volumn 677, Issue 1, 1996, Pages 178-182

  Frye, Reginald F ^a   Branch, Robert A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

4 Hydroxydebrisoquine; Cytochrome P450; Debrisoquine

Indexed keywords

4 HYDROXYDEBRISOQUINE; DEBRISOQUINE; DRUG METABOLITE;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; ENZYME ACTIVITY; FLUORESCENCE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROXYLATION; MUTATION; ORAL DRUG ADMINISTRATION; PHENOTYPE; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TECHNIQUE; URINALYSIS;

EID: 0030005161     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4347(95)00380-0     Document Type: Article

References (20)

1. N.M. Woolhouse, B. Andoh, A. Mahgoub, T.P. Sloan, J.R. Idle and R.L. Smith, Clin. Pharmacol. Ther., 26 (1979) 584.
2. M. Eichelbaum and A.S. Gross, Pharmacol. Ther., (1988) 243.
3. L. Bertilsson, Y.Q. Lou, Y.L. Du, Y. Liu, T.Y. Kuang, X.M. Liao, K.Y. Wang, J. Reviriego, L. Iselius and F. Sjoqvist, Clin. Pharmacol. Ther., 51 (1992) 388.
4. A. Kaisary, P. Smith, E. Jacqz, C.B. McAllister, G.R. Wilkinson, W.A. Ray and R.A. Branch, Cancer Res., 47 (1987) 5488.
5. D.A.P. Evans, A. Mahgoub, T.P. Sloan, J.R. Idle and R.L. Smith, J. Med. Genet., 17 (1980) 102.
6. M.S. Lennard, J.H. Silas, A.J. Smith and G.T. Tucker, J. Chromatogr., 133 (1977) 161.
7. J.G. Allen, P.B. East and J.L. Haigh, Drug. Metab. Dispos., 3 (1975) 332.
8. P. Erdtmansky and T.J. Goehl, Anal. Chem., 47 (1975) 750.
9. J. Moncrieff, J. Chromatogr., 428 (1988) 178.
10. D. Decolin, A. Nicolas, N. Motassim and G. Siest, J. Chromatogr., 419 (1987) 469.
11. B.E. Westwood, P.J. Harman and M.L. Mashford, J. Chromatogr., 374 (1986) 200.
12. P.M. Harrison, A.M. Tonkin, S.T. Dixon and A.J. McLean, J. Chromatogr., 374 (1986) 204.
13. K. Rona, L. Vereczkey and B. Gachalyi, J. Chromatogr., 378 (1986) 509.
14. C.O. Meese, P. Thalheimer and M. Eichelbaum, J. Chromatogr., 423 (1987) 344.
15. K. Chan, J. Chromatogr., 425 (1988) 311.
16. J. Kallio, Int. J. Clin. Pharmacol. Ther. Toxicol., 28 (1990) 223.
17. J. Hempenius, B. Staal, H.J. Jeuring, C.K. Mensink and J.H.G. Jonkman, J. Liq. Chromatogr., 13 (1990) 1627.
18. S.D. Fox, G.L. Shaw, N.B. Caporaso, S.E. Welsh, D.W. Mellini, R. Falk and H.J. Issaq, J. Liq. Chromatogr., 16 (1993) 1315.
19. A. Bozkurt, N.B. Basci, A. Isimer and S.O. Kayaalp, J. Pharm. Biomed. Anal., 11 (1993) 745.
20. L. Bertilsson, C.O. Meese, Q.Y. Yue, M.L. Dahl, M. Ingelman-Sundberg, I. Johansson, J. Sawe and M. Eichelbaum, Pharmacogenetics, 3 (1993) 94.