Effect of sildenafil on the isolated rat aortic rings

Fundamental and Clinical Pharmacology

Volumn 19, Issue 4, 2005, Pages 449-456

  Sharabi, F M ^a   Daabees, T T ^a   El Metwally, M A ^a   Senbel, A M ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Isolated aortic rings; NO cGMP pathway; Sildenafil

Indexed keywords

ACETYLCHOLINE; CYCLIC GMP; METHYLENE BLUE; N(G) NITROARGININE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; SILDENAFIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; ENDOTHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; VASCULAR RING; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; CYCLIC GMP; MALE; NITRIC OXIDE; NITROPRUSSIDE; OMEGA-N-METHYLARGININE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; RATS; VASODILATION;

EID: 22344450035     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2005.00345.x     Document Type: Article

References (50)

1. Boolell M., Gepi-Attee S., Gingell J.C. et al. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br. J. Urol. (1996) 78 257-261.
2. Moreland R.B., Goldstein L, Kim N.N. et al. Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: research and clinical implications in erectile dysfunction. Trends Endocrinol. Met. (1999) 10 97-102.
3. Rajfer J., Aronson W.J., Bush P.A. et al. Nitric oxide as a mediator of relaxation of the corpus cavernosum on response to nonadrenergic noncholinergic neurotransmission. N. Engl. J. Med. (1992) 326 90-94.
4. Langtry H.D., Markham A. Sildenafil: a review of its use in erectile dysfunction. Drugs (1999) 57 967-989.
5. Ballard S.A., Gingell J.C., Tang K. et al. Effects of Sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J. Urol. (1998) 159 2164-2171.
6. Knispel H.H., Goessl C., Beckman R. Basal and acetylcholine-stimulated nitric oxide formation mediates relation of rabbit cavernous smooth muscle. J. Urol. (1991) 146 1429-1433.
7. Saenz De Tejada T., Blanco R., Goldstein T. Cholinergic neurotransmission in human corpus cavernosum. I. Responses of isolated tissue. Am. J. Physiol. (1988) 254 H459-H467.
8. Ignarro L.J., Kadowitz P.J. The pharmacological and physiological role of cGMP in vascular smooth muscle relaxation. Ann. Rev. Pharmacol. Toxicol. (1985) 25 171-191.
9. Jeremy J.Y., Ballard S.A., Naylor A.M. et al. Effects of Sildenafil, a type 5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro. Br. J. Urol. (1997) 79 958-963.
10. G-nitro-L-arginine in rats. Am. J. Physiol. (1992) 263 H1090-H1094.
11. Fahim M., EL-Mas M.M., Abdel Rahman A.A. et al. Influence of aortic baroreceptor denervation on adenosine receptor-mediated relaxation of isolated rat aorta. Eur. J. Pharmacol. (1994) 254 183-191.
12. Laight D.W., Anggard E.E., Carrier M.J. Modulation of nitric oxide-dependent vascular and platelet function in-vitro by the novel phosphodiesterase Type V inhibitor, ONO-1505. J. Pharm. Pharmacol. (1999) 51 1429-1433.
13. Okamura T., Ayajiki K., Fujioka H. et al. Effects of endothelial impairment by saponin on the responses to vasodilators and nitrergic nerve stimulation in isolated canine corpus cavernosum. Br. J. Pharmacol. (1999) 127 802-808.
14. Ignarro L.J., Burke T.M., Wood K.S. et al. Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of intrapulmonary artery. J. Pharmacol. Exp. Ther. (1984) 228 682-690.
15. Holzmann S. Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips. J. Cyclic Nucleotide Res. (1982) 8 409-419.
16. Martin W., Villani G.M., Jothianandan D. et al. Selective blockade of endothelium-dependent and glyceryl trinitrate induced relaxation by hemoglobin and methylene blue in rabbit aorta. J. Pharmacol. Exp. Ther. (1985) 232 S2470-S2476.
17. Rapoport R.M., Murad F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res. (1983) 52 352-357.
18. Kukovetz W.R., Holzmann S., Poch G. Function of cyclic GMP in acetylcholine-induced contraction of coronary smooth muscle. Naunyn Schmiedebergs Arch. Pharmacol. (1982) 319 29-33.
19. Graven P.A., De Rubertis F.R. Restoration of the responsiveness of activated guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemoproteins. J. Biol. Chem. (1978) 253 8433-8443.
20. w-nitro-L-arginine and diphenyleneiodonium. Br. J. Pharmacol. (1995) 114 194-202.
21. Satake N., Imanishi M., Shobata S. Increased nitroglycerin induced relaxation by genistein in rat aortic rings. Eur. J. Pharmacol. (1999) 377 193-197.
22. Schultz K.D., Schultz K., Schultz G. Sodium nitroprusside and other smooth muscle relaxants increase cyclic GMP levels in rat ductus deferens. Nature (1977) 265 750-761.
23. Katsuki S., Murad F. Regulation of adenosine cyclic-3′,5′- monophosphate and guanosine cyclic-3′,5′-monophosphate levels and contractility in bovine tracheal smooth muscle. Mol. Pharmacol. (1977) 13 330-341.
24. Katsuki S., Arnold W., Mittal C. et al. Stimulation of guanylate cyclase by sodium nitroprusside nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J. Cyclic Nucleotide Res. (1977) 3 23-35.
25. Gruetter C.A., Barry B.K., Mc-Namada D.B. et al. Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N-nitrosonornicotine and nitric oxide. J. Pharmacol. Exp. Ther. (1980) 214 9-15.
26. Diamondo J., Chu E.B. Possible role of or cyclic GMP in endothelium dependent relaxation of rabbit aorta by acetylcholine. Comparison with nitroglycerin. Res. Commun. Chem. Pathol. Pharmacol. (1983) 41 369-381.
27. Bauersachs J., Popp R., Hecker M. et al. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation (1996) 94 3341-3347.
28. Deka O.K., Raviprakash V., Mishara S.K. Basal nitric oxide release differentially modulates vasodilations by pinacidil and levcromakalim in goat coronary artery. Eur. J. Pharmacol. (1998) 348 11-23.
29. McCulloch A.L., Randall M.D. Modulation of vasorelaxant responses to potassium channel openers by basal nitric oxide in the rat isolated superior mesenteric arterial bed. Br. J. Pharmacol. (1996) 117 859-866.
30. G-substituted analogues of L-arginine on NANC relaxation of the rat anococcygeus and bovine retractor penis muscle and the bovine penile artery. Br. J. Pharmacol. (1991) 104 53-58.
31. Sharabi P.M., El-Gowelly S.M., Mohy El-Din M.M. Modulatory effect of dopamine on nitrergic transmission of the rat anococcygeus muscle. XIIITh International Congress of Pharmacology, Munchen, Germany, July 26-31, 1998; 749.
32. Kaya T., Sarioglu Y., Goksu O.C. et al. Effect of additional testosterone on purinergic responses in isolated rabbit corpus cavernosum strips. Pharmacol. Res. (1998) 37 227-232.
33. Shirasaki Y., Su C. Endothelium removal augments vasodilation by sodium nitroprusside and sodium nitrite. Eur. J. Pharmacol. (1985) 114 93-96.
34. Rubanyi G., Vanhoutte P.M. Endothelium removal decreases relaxations of canine coronary arteries caused by β-adrenergic agonists and adenosine. J. Cardiovasc. Pharmacol. (1985) 7 139-144.
35. Deply E., Coste H., De Gouville A. Effects of cyclic GMP elevation on isoprenaline induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br. J. Pharmacol. (1996) 119 471-478.
36. Kukovetz W.R., Holzmann S., Wurm A. et al. Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle. Naunyn Schmiedebergs Arch. Pharmacol. (1979) 310 129-138.
37. Dundore R.L., Clas D.M., Wheeler L.T. et al. Zaprinast increases cyclic GMP levels in plasma and in aortic tissue of rats. Eur. J. Pharmacol. (1993) 249 293-297.
38. Noto T., Inoue H., Ikeo T. et al. Potentiation of penile tumescence by T-1032, a new potent and specific phosphodiesterase type V inhibitor, in dogs. J. Pharmacol. Exp. Ther. (2000) 294 870-875.
39. Harris A.L., Lemp B.M., Bentley R.G. et al. Phosphodiesterase isozyme inhibition and the potentiation by zaprinast of derived relaxing factor and guanylate cyclase stimulating agents in vascular smooth muscle. J. Pharmacol. Exp. Ther. (1989) 249 394-400.
40. Merkel L.A., Revera L.M., Perrone M.H. et al. In vitro and in vivo interactions of nitrovasodilators and zaprinast, a cGMP selective phosphodiesterase inhibitor. Eur. J. Pharmacol. (1992) 216 29-35.
41. Sharabi F.M., Daabees T.T., El-Metwally M.A. et al. Comparative effects of sildenafil, phentolamine, yohimbine and L-arginine on the rabbit corpus cavernosum. Fund. Clin. Pharmacol. (2004) 18 187-194.
42. Webb D.J., Freestone S., Allen M.J. et al. Sildenafil citrate and blood pressure lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist. Am. J. Cardiol. (1999) 83 21C-28C.
43. Choi S., O'connell L., Min K. et al. Efficacy of vardenafil and sildenafil in facilitating penile erection in an animal model. J. Andrology (2002) 23 123-128.
44. McAuley I.W., Kim N.N., Min K. et al. Intracavernosal sildenafil facilitates penile erection independent of the nitric oxide pathways. J. Androl. (2001) 22 623-628.
45. Pauvert O., Lugnier C., Keravis T. et al. Effect of sildenafil on cyclic neucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery. Br. J. Pharmacol. (2003) 139 513-522.
46. Mantelli L., Amerini S., Ledda F. et al. The potent relaxant effect of adenosine in rabbit corpus cavernosa is nitric oxide independent and mediated by A-receptors. J. Androl. (1995) 16 312-317.
47. Tong Y.C., Broderick G., Hypolite J. et al. Correlation of purinergic, cholinergic and adrenergic functions in rabbit corporal cavernosal tissue. Pharmacology (1992) 45 241-249.
48. Mochida H., Inoue H., Takagi M. et al. Sildenafil and T-1032, phosphodiesterase type 5 inhibitors, showed a different vasorelaxant property in the isolated rat aorta. Eur. J. Pharmacol. (2002) 440 45-52.
49. Komas N., Lugnier C., Stoclet J. Endothelium dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors. Br. J. Pharmacol. (1991) 104 495-503.
50. Trapani A.J., Smits G.J., McGraw D.E. et al. Haemodynamic basis for the depression activity of zaprinast, a selective cyclic GMP phosphodiesterase inhibitor. J. Pharmacol. Exp. Ther. (1991) 268 269-274.