Modulation of vasorelaxant responses to potassium channel openers by basal nitric oxide in the rat isolated superior mesenteric arterial bed

British Journal of Pharmacology

Volumn 117, Issue 5, 1996, Pages 859-866

  McCulloch, Audrey I ^a   Randall, Michael D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Adenosine; ATP sensitive potassium (K(ATP)) channels; Cyclic GMP; Endothelium; Levcromakalim; Mesenteric arterial bed; N(G) nitro L arginine methyl ester (L NAME); Nitric oxide; Pinacidil; Potassium channel openers KCOs

Indexed keywords

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 1 PROPANESULFONIC ACID; 8 BROMO CYCLIC GMP; 8 PHENYLTHEOPHYLLINE; ADENOSINE; ARGININE METHYL ESTER; CYCLIC GMP; LEMAKALIM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PAPAVERINE; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUPERIOR MESENTERIC ARTERY; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0029865314     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15272.x     Document Type: Article

References (50)

1. 2 receptor mediated coronary vasodilatation in the dog. Cardiovasc. Res., 28, 906-911.
2. ASHCROFT, S.J.H. & ASHCROFT, F.M. (1990). Properties and functions of ATP-sensitive K-channels. Cell. Signalling, 2, 197-214.
3. ASHFORD, M.L.J., STURGESS, N.C., TROUT, N.J., GARDNER, N.J. & HALES, C.N. (1988). Adenosine-5′-triphosphate-sensitive ion channels in neonatal rat cultured central neurones. Pflügers Arch. Pharmacol., 412, 297-304.
4. BOLOTINA, V.M., NAJIBI, S., PALACINO, J.J., PAGANO, P.J. & COHEN, R.A. (1994). Nitric oxide directly activates Ca-activated potassium channels in vascular smooth muscle. Nature, 368, 850-853.
5. + channels in pancreatic β-cells. Nature, 311, 271-273.
6. + channels in trachealis muscle: electrophysiological and mechanical studies in guinea-pig tissue. Br. J. Pharmacol., 109, 1140-1148.
7. DART, C. & STANDEN, N.B. (1993). Adenosine-activated potassium current in smooth muscle cells isolated from the pig coronary artery. J. Physiol., 471, 767-786.
8. EDWARDS, G. & WESTON, A.H. (1990). Potassium channel openers and vascular smooth muscle relaxation. Pharmacol. Ther., 48, 237-258.
9. EDWARDS, G. & WESTON, A.H. (1993). The pharmacology of ATP-sensitive potassium channels. Annu. Rev. Pharmacol. Toxicol., 33, 597-637.
10. + channels by internal acidification in insulin secreting cells. Am. J. Physiol., 267, C1036-C1044.
11. + channels in insulinoma cells via a G-protein. FEBS Lett., 242, 94-96.
12. FURCHGOTT, R.F. & ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
13. G-nitro-L-arginine methyl ester on vasodilator responses to adrenaline or BRL 38227 in conscious rats. Br. J. Pharmacol., 104, 731-737.
14. GRIFFITH, T.M., EDWARDS, D.H., DAVIES, R. Ll., HARRISON, T.J. & EVANS, K.T. (1987). EDRF coordinates the behaviour of vascular resistance vessels. Nature, 329, 442-445.
15. HERITY, N.A., ALLEN, J.D., SILKE, B. & ADGEY, A.A.J. (1994). Assessment of the ability of levcromakalim and sodium nitroprusside to reverse the cardiovascular effects of nitric oxide synthase inhibition in the anaesthetised pig. Cardiovasc. Res., 28, 894-900.
16. + channels in rat aorta and brain microvascular endothelial cells. Am. J. Physiol., 265, C812-C821.
17. JIANG, H., SHABB, J.B. & CORBIN, J.D. (1992). Cross-activation: overiding cAMP/cGMP selectivities of protein kinases in tissues. Biochem. Cell Biol., 70, 1283-1289.
18. 1 receptors by G proteins in rat ventricular myocytes. Am. J. Physiol., 259, H820-H826.
19. KOSTIC, M.M. & SCHRADER, J. (1992). Role of nitric oxide in reactive hyperaemia of guinea pig heart. Circ. Res., 70, 208-212.
20. KRIPPEIT-DREWS, P., MOREL, N. & GODFRAIND, T. (1992). Effect of nitric oxide on membrane potential and contraction of rat aorta J. Cardiovasc. Pharmacol., 20 (Suppl. 12), S72-S75.
21. + channels in isolated membrane patches. J. Physiol., 419, 193-211.
22. + channel opening by stimulation of adenylate cyclase in rat isolated aorta. Br. J. Pharmacol., 115, 515-521.
23. LÜSCHER, T.F. & VANHOUTTE, P.M. (1986). Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension, 8, 344-348.
24. MCCULLOCH, A.I. & RANDALL, M.D. (1995). Modulation of vasorelaxation to potassium channels openers by basal nitric oxide in isolated perfused rat superior mesenteric arterial bed. Br. J. Pharmacol., 116, 174P.
25. MCCULLOCH, A.I. & RANDALL, M.D. (1996). Characterisation of endothelium-dependent relaxations in the isolated perfused rat superior mesenteric arterial bed: the involvement of EDHF. Br. J. Pharmacol., (Proc. Suppl. in press).
26. MILLER, R.C., MONY, M., SCHINI, V., SCHOEFFTER, P. & STOCLET, J.C. (1984). Endothelial mediated inhibition of contraction and increase in cyclic GMP levels evoked by the α-adrenoceptor agonist B-HT 920 in rat isolated aorta. Br. J. Pharmacol., 83, 903-908.
27. + channel in cultured vascular smooth muscle cells. J. Mol. Cell. Cardiol., 26, 1487-1495.
28. + channels of vascular smooth muscle cells. FEBS Lett., 345, 47-49.
29. G-nitro arginine (L-NOARG), a novel, (L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br. J. Pharmacol., 99, 408-412.
30. MURPHY, M.E. & BRAYDEN, J.E. (1995). Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels. J. Physiol., 486, 47-58.
31. + channels. Nature, 344, 770-773.
32. NICHOLS, C.G. & LEDERER, W.J. (1991). Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am. J. Physiol., 261, H1675-H1686.
33. + channels in cardiac muscle. Nature, 305, 147-148.
34. OLAH, M.E. & STILES, G.L. (1992). Adenosine receptors. Annu. Rev. Physiol., 54, 211-225.
35. + current is promoted by internal GDP in frog atrial myocytes. Pflügers Arch. Pharmacol., 414 (Suppl. 1), S177.
36. + channels. Trends Pharmacol. Sci., 10, 431-435.
37. RANDALL, M.D. (1995). The involvement of ATP-sensitive potassium channels and adenosine in the regulation of coronary flow in the isolated perfused rat heart. Br. J. Pharmacol., 116, 3068-3074.
38. RANDALL, M.D. & GRIFFITH, T.M. (1993). Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil. Br. J. Pharmacol., 109, 386-393.
39. RANDALL, M.D. & HILEY, C.R. (1988). Effect of phenobarbitone pretreatment upon endothelium-dependent relaxation to acetylcholine in rat superior mesenteric arterial bed. Br. J. Pharmacol., 94, 977-983.
40. RANDALL, M.D. & MCCULLOCH, A.I. (1995). The involvement of ATP-sensitive potassium channels in β-adrenoceptor-mediated vasorelaxation in the rat isolated mesenteric arterial bed. Br. J. Pharmacol., 115, 607-612.
41. RANDALL, M.D., UJIIE, H. & GRIFFITH, T.M. (1994). Modulation of vasodilatation by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation. Br. J. Pharmacol., 112, 49-54.
42. RAPOPORT, R.M. & MURAD, F. (1983). Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res., 52, 352-357.
43. + channels in cerebral artery smooth muscle cells. Am. J. Physiol., 265, C299-C303.
44. SPRUCE, A.E., STANDEN, N.B. & STANFIELD, P.R. (1985). Voltage-dependent ATP-sensitive potassium channels of skeletal muscle membrane. Nature, 316, 736-738.
45. + channels in arterial smooth muscle. Science, 24, 177-180.
46. STURGESS, NC, ASHFORD, M.L.J., COOK, D.L. & HALES, C.N. (1985). The sulphonylurea receptor may be an ATP-sensitive potassium channel. Lancet, ii, 474-475.
47. TARE, M., PARKINGTON, H.C., COLEMAN, H.A., NEILD, T.O. & DUSTING, G.J. (1990). Hyperpolarisation and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium. Nature, 346, 69-71.
48. VERBEUREN, T.J., JORDAENS, F.H., ZONNEKEYN, L.L., VAN HOVE, C.E., COENE, M-C. & HERMAN, A.C. (1986). Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Circ. Res., 58, 552-564.
49. VON BEKERATH, N., CYRYS S., DISCHNER, A. & DAUT, J. (1991). Hypoxic vasodilatation in isolated, perfused guinea-pig heart: an analysis of the underlying mechanisms. J. Physiol., 442, 297-319.
50. + channels in vascular smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A., 85, 9360-9364.