Anti-varicella-zoster virus bicyclic nucleosides: Replacement of furo by pyrro base reduces antiviral potency

Antiviral Chemistry and Chemotherapy

Volumn 11, Issue 5, 2000, Pages 343-348

  McGuigan, C ^a   Pathirana, R N ^a   Jones, G ^a   Andrei, G ^a   Snoeck, R ^a   De Clercq, E ^a   Balzarini, J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Bicyclic nucleosides; Nucleoside analogues; Shingles; Varicella zoster virus; Zoster

Indexed keywords

NUCLEOSIDE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES ZOSTER; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VARICELLA ZOSTER VIRUS;

EID: 0034532969     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020001100505     Document Type: Article

References (10)

1. Antiviral and antitumor activities of 5-substituted 2′-deoxyuridines
2. Biochemical aspects of the selective antiherpes activity of nucleoside analogs
3. (E)-5-(2-bromovinyl)-2′-deoxyuridine, a potent and selective antiherpes agent
4. Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus
5. Steric fixation of bromovinyluracil - Synthesis of furo[2,3-D]pyrimidine nucleosides
6. Synthesis and biological evaluation of 5-(1-Alkoxy-2-Haloethyl)-2′-deoxyuridines and related uracil analogs
7. Synthesis of 5-(1-azidovinyl) and 5-[2-(1-azirinyl)] analogs of 2′-deoxyuridine
8. Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base
9. Nucleic-acid related-compounds.39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides
10. G/C-modified oligodeoxynucleotides with selective complementarity: Synthesis and hybridization properties