Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: Effect of enhanced aqueous solubility

Antiviral Chemistry and Chemotherapy

Volumn 11, Issue 6, 2000, Pages 383-393

  Brancale, A ^a   Srinivasan, S ^a   McGuigan, C ^a   Andrei, G ^a   Snoeck, R ^a   De Clercq, E ^a   Balzarini, J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

5 iodo 2 deoxyuridine; Antiviral; Nucleoside inhibitors; Varicella zoster virus

Indexed keywords

ACICLOVIR; ALKYNE DERIVATIVE; ANTIVIRUS AGENT; COPPER DERIVATIVE; GLYCOL; IDOXURIDINE; NUCLEOSIDE DERIVATIVE; PALLADIUM;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SOLUBILITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIPOPHILICITY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; VARICELLA ZOSTER VIRUS;

EID: 0034487641     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020001100605     Document Type: Article

References (15)

1. A formal total synthesis of (±)-Strigol
2. Bicyclic nucleoside inhibitors of varicella-zoster virus: The effect of a terminal halogen substitution in the side-chain
3. (E)-5-(2-Bromovinyl)-2′-deoxyuridine; a potent and selective anti-herpes agent
4. Antiviral and antitumor activities of 5-substituted 2′-deoxyuridines
5. Comparative efficacy of anti-herpes drugs against different strains of herpes simplex virus
6. Biochemical aspects of the selective antiherpes activity of nucleoside analogues
7. Steric fixation of bromovinyluracil - Synthesis of furo[2,3-d] pyrimidine nucleosides
8. Novel reagent system for converting a hydroxy-group into an iodo-group in carbohydrates with inversion of configuration
9. Synthesis and properties of 5-(1,2-dihaloethyl)-2′-deoxyuridines and related analogues
10. Synthesis of 5-(1-azidovinyl) and 5-[-(1-azirinyl)] analogs of 2′-deoxyuridine
11. Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base
12. Fluorescent bicyclic furo deoxynucleoside analogues as potent and selective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles
13. Highly potent and selective inhibition of varicella-zoster virus (VZV) by bicyclic furo pyrimidine nucleosides bearing an aryl side-chain
14. Nucleic acid-related compounds. 39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides
15. Preparation of alkynes and dialkynes by reaction of monohalo- and dihaloalkanes with lithium acetylenide-ethylene diamine complex