Effects of sodium aescinate on Bcl-2 and Caspase-3 expression and apoptosis after focal cerebral ischemia reperfusion injury in rats

Journal of Central South University (Medical Sciences)

Volumn 30, Issue 3, 2005, Pages

  Fan, Xue Jun ^a   Guo, Ke ^a   Xiao, Bo ^b   Zi, Xiao Hong ^a   Song, Zhi ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2; Caspase 3; Ischemical reperfusion injury; Sodiun aescinate

Indexed keywords

CASPASE 3; PROTEIN BCL 2; SODIUM CHLORIDE; SODIUM DERIVATIVE; SODIUM ESCINATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CELL COUNT; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY; MIDDLE CEREBRAL ARTERY OCCLUSION; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ALGINATES; ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CASPASE 3; CASPASES; GLUCURONIC ACID; HEXURONIC ACIDS; MALE; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RATS; RATS, WISTAR; REPERFUSION INJURY; SAPONINS;

EID: 22244433193     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Linnik MD, Zahos P, Geschwind MD, et al. Expression of bcl-2 from defective herpes simplex vector limits neuronal death in focal cerebral ischemia[J]. Stroke, 1995,26(9):1670-1675.
2. Chen J, Graham SH, Nakayama M, et al. Apoptosis represser gene bcl-2 and bcl-xl are expressed in the rat brain following global ischemia[J]. J Cereb Blood Flow Metab, 1997,11(1):1-10.
3. Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral ar-tery occlusion without carniectomy in rats[J]. Stroke, 1989,20(1):84-91.
4. Shi J, Panickar KS, Yang SH, et al. Estrogen attenuates over expression of beta amyloid precursor protein messenger RNA in an animal model of focal ischemia[J]. Brain Res, 1998,810(12):87-92.
5. Lipton P. Ischemic cell death in brain neurons[J]. Physiol Rev, 1999,79(4):1431-1568.
6. Dirnagl U, adecola C, Moskowitz MA. Pathobiology of ischemic strokeran integrated view[J]. Trends Neurosci 1999,22(9):391-397.
7. Chinese Source
8. Martinou JC, Dubois DM, Staple JK, et al. Overexpression of Bcl-2 in transgene mice protects neurons from naturally occuring cell death and experimental ischemia[J]. Neuron, 1994,13(4):1017-1025.
9. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspase: structure, acti-vation, substrates, and functions during apoptisos [J]. Annu Rev Biochem, 1999,68(1):383424.
10. Yuan J, Yankner BA. Apoptosis in the nervous system [J]. Nature, 2000,407(6805):802-809.
11. Chen J, Nagayama T, Jin K, et al. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia[J]. Neurosci, 1998,18(13):4914-4928.
12. Granville DJ, Jiang H, An MT, et al. Bcl-2 overexpression blocks Caspase activation and downstream apoptotic events instigated by photodynamic therapy[J]. Br J Cancer, 1999,79(1):95-100.
13. Swanton E, Savory P, Cosulich S, et al. Bcl-2 regulates a Caspase/Caspase-2 apoptotic cascade in cytosolic extraxts[J]. Oncogene, 1999,18(10):1781-1792.
14. Patel M. Inhibition of the neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic [J]. J Neurochem, 1998,71(3): 1068-1074.
15. Guillaume M, Padioleau F. Veinotonic effect, vascular protection, anti-inflammatory and free radical scavenging properties of horse chestnut extract [J]. Arzneim ittel-forschung, 1994,44(1):25-35.