p63-specific activation of the BPAG-1e promoter

Journal of Investigative Dermatology

Volumn 125, Issue 1, 2005, Pages 52-60

  Osada, Motonobu ^a   Nagakawa, Yuichi ^a   Park, Hannah Lui ^a   Yamashita, Keishi ^a   Wu, Guojun ^a   Kim, Myoung Sook ^a   Fomenkov, Alexey ^a   Trink, Barry ^a   Sidransky, David ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BPAG 1; p53; p53 response element; p63

Indexed keywords

BULLOUS PEMPHIGOID ANTIGEN 1; COMPLEMENTARY DNA; LUCIFERASE; PROTEIN P63;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ECTODERMAL DYSPLASIA; ENZYME ASSAY; FOOT MALFORMATION; GENODERMATOSIS; HAND MALFORMATION; IMMUNOHISTOCHEMISTRY; MOUSE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN EPITHELIUM; SYNDROME DELINEATION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

EID: 22144464469     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23801.x     Document Type: Article

References (47)

1. Amiel J, Bougeard G, Francannet C, Raclin V, Munnich A, Lyonnet S, Frebourg T: TP63 gene mutation in ADULT syndrome. Eur J Hum Genet 9:642-645, 2001
2. Borradori L, Sonnenberg A: Structure and function of hemidesmosomes: More than simple adhesion complexes. J Invest Dermatol 112:411-418, 1999
3. Brunner HG, Hamel BC, Van Bokhoven H: Thep63 gene in EEC and other syndromes. J Med Genet 39:377-381, 2002
4. Celli J, Duijf P, Hamel BC, et al: Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell 99:143-153, 1999
5. Chen PL, Chen YM, Bookstein R, Lee WH: Genetic mechanisms of tumor suppressor by the human p53 gene. Science 250:1576-1580, 1990
6. Dohn M, Zhang S, Chen X: p63alpha and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene 20:3193-3205, 2001
7. Diller L, Kassel J, Nelson CE, et al: p53 function as a cell cycle control protein in osteosarcomas. Mol Cell Biol 10:5772-5781, 1990
8. el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B: Definition of a consensus binding site for p53. Nat Genet 1:45-49, 1992
9. Fontao L, Favre B, Riou S, et al: Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus. Mol Biol Cell 14: 1978-1992, 2003
10. Ghioni P, Bolognese F, Duijf PH, Van Bokhoven H, Mantovani R, Guerrini L: Complex transcriptional effects of p63 isoforms: Identification of novel activation and repression domains. Mol Cell Biol 22:8659-8668, 2002
11. Ianakiev P, Kilpatrick MW, Toudjarska I, Basel D, Beighton P, Tsipouras P: Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27. Am J Hum Genet 67:59-66, 2000
12. Inga A, Storici F, Darden TA, Resnick MA: Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol Cell Biol 22:8612-8625, 2002
13. Johnson SAS, Dubeau L, White RJ, Johnson DL: The TATA-binding protein as regulator of cellular transformation. Cell Cycle 2:442-444, 2003
14. King KE, Ponnamperuma RM, Yamashita T, Tokino T, Lee LA, Young MF: Weinberg WC:ΔNp63α functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. Oncogene 22:3635-3644, 2003
15. Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR: p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 18:126-131, 2004
16. Lehman TA, Modali R, Boukamp P, et al: p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14:833-839, 1993
17. Leung CL, Green KJ, Liem RK: Plakins: A family of versatile cytolinker proteins. Trends Cell Biol 12:37-45, 2002
18. Leung CL, Liem RK, Parry DA, Green KJ: The plakin family. J Cell Sci 114: 3409-3410, 2001
19. Matsuzaki Y, Tamai K, Kon A, Sawamura D, Uitto J, Hashimoto I: Keratinocyte responsive element 3: Analysis of a keratinocyte-specific regulatory sequence in the 230-kDa bullous pemphigoid antigen gene promoter. J Invest Dermatol 120:308-312, 2003
20. McGrath JA, Duijf PH, Doetsch V, et al: Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Hum Mol Genet 10:221-229, 2001
21. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A: p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398: 708-713, 1999
22. Nylander K, Vojtesek B, Nenutil R, et al: Differential expression of p63 isoforms in normal tissues and neoplastic cells. J Pathol 198:417-427, 2002
23. Okumura M, Yamakawa H, Ohara O, Owaribe K: Novel alternative splicings of BPAG1 (bullous pemphigoid antigen 1) including the domain structure closely related to MACF (microtubule actin cross-linking factor). J Biol Chem 277:6682-6687, 2002
24. Osada M, Inaba R, Shinohara H, Hagiwara M, Nakamura M, Ikawa Y: Regulatory domain of protein stability of human P51/TAP63, a P53 homologue. Biochem Biophys Res Commun 283:1135-1141, 2001
25. Osada M, Ohba M, Kawahara C, et al: Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med 4: 839-843, 1998
26. Papoutsaki M, Lanza M, Marinari B, et al: The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene. J Invest Dermatol 123:1162-1168, 2004
27. Pellegrini G, Dellambra E, Golisano O, et al. p63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 98:3156-3161, 2001
28. Roper K, Gregory SL, Brown NH: The 'spectraplakins': Cytoskeletal giants with characteristics of both spectrin and plakin families. J Cell Sci 115: 4215-4225, 2002
29. Sasaki Y, Ishida S, Morimoto I, et al. The p53 family member genes are involved in the Notch signal pathway. J Biol Chem 277:719-724, 2002
30. Sasaki Y, Mita H, Toyota M, et al: Identification of the interleukin 4 receptor alpha gene as a direct target for p73. Cancer Res 63:8145-6152, 2003
31. Schmale H, Bamberger C: A novel protein with strong homology to the tumor suppressor p53. Oncogene 15:1363-1367, 1997
32. Senoo M, Seki N, Ohira M, et al: A second p53-related protein, p73L, with high homology to p73. Biochem Biophys Res Commun 248:603-607, 1998
33. Serber Z, Lai HC, Yang A, et al: A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol Cell Biol 22: 8601-8611, 2002
34. Sim EU, Smith A, Szilagi E, Rae F, Ioannou P, Lindsay MH, Little MH: Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1. Oncogene 21: 2948-2960, 2002
35. Stappenbeck TS, Bornslaege EA, Corcoran CM, Luu HH, Virata ML, Green KJ: Functional analysis of desmoplakin domains: Specification of the interaction with keratin versus vimentin intermediate filament networks. J Cell Biol 123:691-705, 1993
36. Tamai K, Li K, Uitto J: Identification of a DNA-binding protein (keratinocyte transcriptional protein-1) recognizing a keratinocyte-specific regulatory element in the 230-kDa bullous pemphigoid antigen gene. J Biol Chem 269:493-502, 1994a
37. Tamai K, Sawamura D, Choi Do HY, Li K, Uitto J: Molecular biology of the 230-kD bullous pemphigoid antigen. Cloning of the BPAG1 gene and its tissues-pecific expression. Dermatology 189 Suppl 1:27-33, 1994b
38. Tamai K, Sawamura D, Do HC, Tamai Y, Li K, Uitto J: The human 230-kD bullous pemphigoid antigen gene (BRAGJ). Exon-intron organization and identification of regulatory tissue specific elements in the promoter region. J Clin Invest 92:814-822, 1993
39. Tamai K, Silos SA, Li K, Korkeela E, Ishikawa H, Uitto J: Tissue-specific expression of the 230-kDa bullous pemphigoid antigen gene (BPAG1). Identification of a novel keratinocyte regulatory cis-element KRE3. J Biol Chem 270:7609-7614, 1995
40. Tokino T, Thiagalingam S, el-Deiry WS, Waldman T, Kinzler KW, Vogelstein B: p53 tagged sites from human genomic DNA. Hum Mol Genet 3:1537-1542, 1994
41. Trink B, Okami K, Wu L, Sriuranpong V, Jen J, Sidransky D: A new human p53 homologue. Nat Med 4:747-748, 1998
42. van Bokhoven H, Brunner HG: Splitting p63. Am J Hum Genet 71:1-13, 2002
43. van Bokhoven H, McKeon F: Mutations in the p53 homolog p63: Allele-specific developmental syndromes in humans. Trends Mol Med 8:133-139, 2002
44. Vogelstein B, Kinzler KW: p53 function and dysfunction. Cell 70:523-526, 1992
45. Wu G, Osada M, Quo Z, et al: ΔNp63α up-regulates the hsp70 gene in human cancer. Cancer Res 65:758-766, 2005
46. Yang A, Kaghad M, Wang Y: p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2:305-316, 1998
47. Yang A, Schweitzer R, Sun D: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398:714-713, 1999