Dopamine D4 receptor antagonist 3-(4-[18F] fluorobenzyl)-8-methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one([ 18F]FMTP): Radiosynthesis and in vivo characterization in rats

Applied Radiation and Isotopes

Volumn 63, Issue 3, 2005, Pages 333-342

  Hai Bin, Tian ^a   Duan Zhi, Yin ^a   Lan, Zhang ^a   Li Hua, Wang ^a   Chun Fu, Zhang ^a   Ming Wei, Wang ^a   Chun Ying, Wu ^b   Gu Cai, Li ^a   Yong Xian, Wang ^a  

^a SHANGHAI INSTITUTE OF APPLIED PHYSICS   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Chromeno 3; 4 c pyridin; Dopamine D4 receptor; Fluorine 18; Metabolism; PET; Tissue distribution

Indexed keywords

BRAIN; FLUORINE COMPOUNDS; LIVING SYSTEMS STUDIES; NEUROLOGY; PURIFICATION; RADIOACTIVE ELEMENTS; REDUCTION; SYNTHESIS (CHEMICAL);

NONRADIOACTIVE; RADIOLIGANDS; RADIOSYNTHESIS; TISSUE DISTRIBUTIONS;

RADIOISOTOPES;

3 (4 FLUOROBENZYL) 8 METHOXY 1,2,3,4 TETRAHYDROCHROMENO[3,4 C]PYRIDIN 5 ONE F 18; BRAIN EXTRACT; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; FLUORINE 18; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; REACTION ANALYSIS; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

ANIMALS; BENZOPYRANS; BRAIN; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MALE; MOLECULAR STRUCTURE; PYRIDONES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; TISSUE DISTRIBUTION;

EID: 22044445239     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2005.04.004     Document Type: Article

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