Synthesis and evaluation of 3-(4-chlorobenzyl)-8-[11C]methoxy-1,2,3,4-tetrahydrochromeno [3,4-c]pyridin-5-one: A PET tracer for imaging sigma1 receptors

Nuclear Medicine and Biology

Volumn 29, Issue 4, 2002, Pages 469-476

  Zhang, Ming Rong ^a   Haradahira, Terushi ^c   Maeda, Jun ^a,b   Okauchi, Takashi ^a,b   Kawabe, Kouichi ^a   Kida, Takayo ^a,b   Suzuki, Kazutoshi ^c   Suhara, Tetsuya ^a,c  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c 141 0032   (Japan)

Author keywords

Autoradiography; Carbon 11; Dopamine D4 receptors; PET; Sigma1 receptors

Indexed keywords

3 (4 CHLOROBENZYL) 8 HYDROXY 1,2,3,4 TETRAHYDROCHROMENO[3,4 C]PYRIDIN 5 ONE; 3 (4 CHLOROBENZYL) 8 METHOXY 1,2,3,4 TETRAHYDROCHROMENO[3,4 C]PYRIDIN 5 ONE; 3 (4 CHLOROBENZYL) 8 METHOXY 1,2,3,4 TETRAHYDROCHROMENO[3,4 C]PYRIDIN 5 ONE C 11; 3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BRAIN RECEPTOR; KETAMINE; PENTAZOCINE; RADIOPHARMACEUTICAL AGENT; RBI 254; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG; 3 (4 CHLOROBENZYL) 8 METHOXY 1,2,3,4 TETRAHYDROCHROMENO(3,4 C)PYRIDIN 5 ONE; 3-(4-CHLOROBENZYL)-8-METHOXY-1,2,3,4-TETRAHYDROCHROMENO(3,4-C)PYRIDIN-5-ONE; COUMARIN DERIVATIVE; DIAGNOSTIC AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DRD4 PROTEIN, RAT; PYRIDINE DERIVATIVE; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DIAGNOSTIC IMAGING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; METHYLATION; MONKEY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRECURSOR; PURIFICATION; RADIOACTIVITY; RADIOCHEMISTRY; REDUCTION; THALAMUS; ANIMAL; BRAIN; COMPARATIVE STUDY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; EVALUATION; FRONTAL LOBE; MACACA; MALE; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; RAT; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMAL; BRAIN; CEREBELLUM; COMPARATIVE STUDY; CORPUS STRIATUM; COUMARINS; FRONTAL LOBE; IN VITRO; MACACA MULATTA; MALE; METABOLIC CLEARANCE RATE; PENTAZOCINE; PYRIDINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, SIGMA; SENSITIVITY AND SPECIFICITY; THALAMUS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED; ANIMALS; RECEPTORS, DOPAMINE D4;

EID: 0035988215     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(02)00293-7     Document Type: Article

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