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Volumn 80, Issue 6, 2005, Pages 877-886

Fluorescence resonance energy transfer analysis of apolipoprotein E C-terminal domain and amyloid β peptide (1-42) interaction

Author keywords

AEDANS; Amyloid peptide; Apolipoprotein E Alzheimer's disease; Fluorescence; Fluorescence resonance energy; Oligomerization; Quenching; Transfer; Tryptophan

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; CYSTEINE; ETHYLENEDIAMINE DERIVATIVE; N (IODOACETYL) N' (5 SULFO 1 NAPHTHYL)ETHYLENEDIAMINE; POTASSIUM IODIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

EID: 21844473805     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20503     Document Type: Article
Times cited : (21)

References (57)
  • 1
    • 0023937366 scopus 로고
    • Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- And carboxyl-terminal domains
    • Aggerbeck LP, Wetterau JR, Weisgraber KH, Wu CS, Lindgren FT. 1988. Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains. J Biol Chem 263:6249-6258.
    • (1988) J Biol Chem , vol.263 , pp. 6249-6258
    • Aggerbeck, L.P.1    Wetterau, J.R.2    Weisgraber, K.H.3    Wu, C.S.4    Lindgren, F.T.5
  • 2
    • 0030867936 scopus 로고    scopus 로고
    • Interaction of nascent apoE2, apoE3, and apoE4 isoforms expressed in mammalian cells with amyloid peptide â(1-40): Relevance to Alzheimer's disease
    • Aleshkov SB, Abraham C, Zannis VI. 1997. Interaction of nascent apoE2, apoE3, and apoE4 isoforms expressed in mammalian cells with amyloid peptide â(1-40): relevance to Alzheimer's disease. Biochemistry 36:10571-10580.
    • (1997) Biochemistry , vol.36 , pp. 10571-10580
    • Aleshkov, S.B.1    Abraham, C.2    Zannis, V.I.3
  • 3
    • 0033551431 scopus 로고    scopus 로고
    • Contribution of cysteine 158, the glycosylation site threonine 194, the amino- And carboxy-terminal domains of apolipoprotein e in the binding to amyloid peptide β(1-40)
    • Aleshkov SB, Li X, Lavrentiadou SN, Zannis VI. 1999. Contribution of cysteine 158, the glycosylation site threonine 194, the amino- and carboxy-terminal domains of apolipoprotein E in the binding to amyloid peptide β(1-40). Biochemistry 38:8918-8925.
    • (1999) Biochemistry , vol.38 , pp. 8918-8925
    • Aleshkov, S.B.1    Li, X.2    Lavrentiadou, S.N.3    Zannis, V.I.4
  • 5
    • 0037103744 scopus 로고    scopus 로고
    • Apolipoprotein e structural requirements for the formation of SDS-stable complexes with β-amyloid-(1-40): The role of salt bridges
    • Bentley NM, Ladu MJ, Rajan C, Getz GS, Reardon CA. 2002. Apolipoprotein E structural requirements for the formation of SDS-stable complexes with β-amyloid-(1-40): the role of salt bridges. Biochemistry 366:273-279.
    • (2002) Biochemistry , vol.366 , pp. 273-279
    • Bentley, N.M.1    Ladu, M.J.2    Rajan, C.3    Getz, G.S.4    Reardon, C.A.5
  • 7
    • 0029905421 scopus 로고    scopus 로고
    • Native complex formation between apolipoprotein e isoforms and the Alzheimer's disease peptide Aβs
    • Chan W, Fornwald J, Brawner M, Wetzel R. 1996. Native complex formation between apolipoprotein E isoforms and the Alzheimer's disease peptide Aβs. Biochemistry 35:7123-7130.
    • (1996) Biochemistry , vol.35 , pp. 7123-7130
    • Chan, W.1    Fornwald, J.2    Brawner, M.3    Wetzel, R.4
  • 8
    • 0242662225 scopus 로고    scopus 로고
    • Inter molecular coiled-coil formation in human apolipoprotein e C-terminal domain
    • Choy N, Raussens V, Narayanaswami V. 2003. Inter molecular coiled-coil formation in human apolipoprotein E C-terminal domain. J Mol Biol 334:527-539.
    • (2003) J Mol Biol , vol.334 , pp. 527-539
    • Choy, N.1    Raussens, V.2    Narayanaswami, V.3
  • 9
    • 4143105546 scopus 로고    scopus 로고
    • Apolipoprotein e is a prime suspect, not just an accomplice, in Alzheimer's disease
    • Crutcher KA. 2004. Apolipoprotein E is a prime suspect, not just an accomplice, in Alzheimer's disease. J Mol Neurosci 23:181-188.
    • (2004) J Mol Neurosci , vol.23 , pp. 181-188
    • Crutcher, K.A.1
  • 10
    • 0037200117 scopus 로고    scopus 로고
    • Oligomeric and fibrillar species of amyloid-b peptides differentially affect neuronal viability
    • Dahlgren KN, Manelli AM, Stine WB Jr, Baker LK, Krafft GA, LaDu MJ. 2002. Oligomeric and fibrillar species of amyloid-b peptides differentially affect neuronal viability. J Biol Chem 277:32046-32053.
    • (2002) J Biol Chem , vol.277 , pp. 32046-32053
    • Dahlgren, K.N.1    Manelli, A.M.2    Stine Jr., W.B.3    Baker, L.K.4    Krafft, G.A.5    Ladu, M.J.6
  • 11
    • 0028092997 scopus 로고
    • Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms
    • Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA. 1994. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J Biol Chem 269:22358-22365.
    • (1994) J Biol Chem , vol.269 , pp. 22358-22365
    • Dong, L.M.1    Wilson, C.2    Wardell, M.R.3    Simmons, T.4    Mahley, R.W.5    Weisgraber, K.H.6    Agard, D.A.7
  • 12
    • 0029766916 scopus 로고    scopus 로고
    • Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins
    • Dong LM, Weisgraber KH. 1996. Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J Biol Chem 271:19053-19057.
    • (1996) J Biol Chem , vol.271 , pp. 19053-19057
    • Dong, L.M.1    Weisgraber, K.H.2
  • 13
    • 0004982358 scopus 로고
    • Apolipoprotein e mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets
    • Elshourbagy NA, Liao WS, Mahley RW, Taylor JM. 1985. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci USA 82:203-207.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 203-207
    • Elshourbagy, N.A.1    Liao, W.S.2    Mahley, R.W.3    Taylor, J.M.4
  • 14
    • 0034663336 scopus 로고    scopus 로고
    • Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-β deposition in vivo
    • Fagan AM, Holtzman DM. 2000. Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-β deposition in vivo. Microsc Res Tech 50:297-304.
    • (2000) Microsc Res Tech , vol.50 , pp. 297-304
    • Fagan, A.M.1    Holtzman, D.M.2
  • 15
    • 0032101868 scopus 로고    scopus 로고
    • Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury
    • Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM. 1998. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp Neurol 151: 314-325.
    • (1998) Exp Neurol , vol.151 , pp. 314-325
    • Fagan, A.M.1    Murphy, B.A.2    Patel, S.N.3    Kilbridge, J.F.4    Mobley, W.C.5    Bu, G.6    Holtzman, D.M.7
  • 16
    • 0034721777 scopus 로고    scopus 로고
    • The lipid-associated conformation of the low density lipoprotein receptor binding domain of human apolipoprotein E
    • Fisher CA, Narayanaswami V, Ryan RO. 2000. The lipid-associated conformation of the low density lipoprotein receptor binding domain of human apolipoprotein E. J Biol Chem 275:33601-33606.
    • (2000) J Biol Chem , vol.275 , pp. 33601-33606
    • Fisher, C.A.1    Narayanaswami, V.2    Ryan, R.O.3
  • 17
    • 0030611858 scopus 로고    scopus 로고
    • Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrations
    • Garzon-Rodriguez W, Sepulveda-Becerra M, Milton S, Glabe CG. 1997. Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrations. J Biol Chem 272:21037-21044.
    • (1997) J Biol Chem , vol.272 , pp. 21037-21044
    • Garzon-Rodriguez, W.1    Sepulveda-Becerra, M.2    Milton, S.3    Glabe, C.G.4
  • 18
    • 0033869207 scopus 로고    scopus 로고
    • Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid β-peptide with the N-terminal, receptor binding domain of apolipoprotein E
    • Golabek AA, Kida E, Walus M, Perez C, Wisniewski T, Soto C. 2000. Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid β-peptide with the N-terminal, receptor binding domain of apolipoprotein E. Biophys J 779:1008-1015.
    • (2000) Biophys J , vol.779 , pp. 1008-1015
    • Golabek, A.A.1    Kida, E.2    Walus, M.3    Perez, C.4    Wisniewski, T.5    Soto, C.6
  • 19
    • 0029866177 scopus 로고    scopus 로고
    • The interaction between apolipoprotein e and Alzheimer's amyloid β-peptide is dependent on β-peptide conformation
    • Golabek AA, Soto C, Vogel T, Wisniewski T. 1996. The interaction between apolipoprotein E and Alzheimer's amyloid β-peptide is dependent on β-peptide conformation. J Biol Chem 271:10602-10606.
    • (1996) J Biol Chem , vol.271 , pp. 10602-10606
    • Golabek, A.A.1    Soto, C.2    Vogel, T.3    Wisniewski, T.4
  • 20
    • 0037343967 scopus 로고    scopus 로고
    • Apolipoprotein e enhances uptake of soluble but not aggregated amyloid-b protein into synaptic terminals
    • Gylys KK, Fein JA, Tan AM, Cole GM. 2003. Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-b protein into synaptic terminals. J Neurochem 84:1442-1451.
    • (2003) J Neurochem , vol.84 , pp. 1442-1451
    • Gylys, K.K.1    Fein, J.A.2    Tan, A.M.3    Cole, G.M.4
  • 21
    • 0032491408 scopus 로고
    • Genetic classification of primary neurodegenerative disease
    • Hardy J, Gwinn-Hardy K. 1988. Genetic classification of primary neurodegenerative disease. Science 282:1075-1079.
    • (1988) Science , vol.282 , pp. 1075-1079
    • Hardy, J.1    Gwinn-Hardy, K.2
  • 23
    • 0034122869 scopus 로고    scopus 로고
    • Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease
    • Hyman BT, Strickland D, Rebeck GW. 2000. Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease. Arch Neurol 57:646-650.
    • (2000) Arch Neurol , vol.57 , pp. 646-650
    • Hyman, B.T.1    Strickland, D.2    Rebeck, G.W.3
  • 25
    • 0027258525 scopus 로고
    • The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • Jarrett JT, Berger EP, Lansbury PT Jr. 1993. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-4697.
    • (1993) Biochemistry , vol.32 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury Jr., P.T.3
  • 28
    • 0001252358 scopus 로고    scopus 로고
    • Energy transfer
    • New York: Kluwer Academic/Plenum Publishers
    • Lakowicz JR. 1999. Energy transfer. In: Principles of Fluorescence Spectroscopy. New York: Kluwer Academic/Plenum Publishers p. 367-394.
    • (1999) Principles of Fluorescence Spectroscopy , pp. 367-394
    • Lakowicz, J.R.1
  • 30
    • 0032802312 scopus 로고    scopus 로고
    • Molecular determinants of the interaction between the C-terminal domain of Alzheimer's b-amyloid peptide and apolipoprotein E alpha-helices
    • Lins L, Thomas-Soumarmon A, Pillot T, Vandekerckhove J, Rosseneu, Brasseur R. 1999. Molecular determinants of the interaction between the C-terminal domain of Alzheimer's b-amyloid peptide and apolipoprotein E alpha-helices. J Neurochem 73:758-769.
    • (1999) J Neurochem , vol.73 , pp. 758-769
    • Lins, L.1    Thomas-Soumarmon, A.2    Pillot, T.3    Vandekerckhove, J.4    Rosseneu5    Brasseur, R.6
  • 31
    • 0032839621 scopus 로고    scopus 로고
    • Apolipoprotein E: From atherosclerosis to Alzheimer's disease and beyond
    • Mahley RW, Huang Y. 1999. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr Opin Lipidol 10:207-217.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 207-217
    • Mahley, R.W.1    Huang, Y.2
  • 35
    • 0025971426 scopus 로고
    • Apolipoprotein e immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
    • Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. 1991. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 541:163-166.
    • (1991) Brain Res , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 36
    • 0027518128 scopus 로고
    • Protein-lipid interactions and Torpedo californica nicotinic acetylcholine receptor function. 1. Spatial disposition of cysteine residues in the gamma subunit analyzed by fluorescence-quenching and energy-transfer measurements
    • Narayanaswami V, Kim J, McNamee MG. 1993. Protein-lipid interactions and Torpedo californica nicotinic acetylcholine receptor function. 1. Spatial disposition of cysteine residues in the gamma subunit analyzed by fluorescence-quenching and energy-transfer measurements. Biochemistry 32:12413-12419.
    • (1993) Biochemistry , vol.32 , pp. 12413-12419
    • Narayanaswami, V.1    Kim, J.2    McNamee, M.G.3
  • 37
    • 0033991858 scopus 로고    scopus 로고
    • Molecular basis of exchangeable apolipoprotein function
    • Narayanaswami V, Ryan RO. 2000. Molecular basis of exchangeable apolipoprotein function. Biochim Biophys Acta 1483:15-36.
    • (2000) Biochim Biophys Acta , vol.1483 , pp. 15-36
    • Narayanaswami, V.1    Ryan, R.O.2
  • 38
    • 0035851137 scopus 로고    scopus 로고
    • Lipid-association induced N- And C-terminal domain reorganization in human apolipoprotein E3
    • Narayanaswami V, Szeto S, Ryan RO. 2001. Lipid-association induced N- and C-terminal domain reorganization in human apolipoprotein E3. J Biol Chem 276:37853-37860.
    • (2001) J Biol Chem , vol.276 , pp. 37853-37860
    • Narayanaswami, V.1    Szeto, S.2    Ryan, R.O.3
  • 39
    • 0034711265 scopus 로고    scopus 로고
    • Self-association of human apolipoprotein E3 and E4 in the presence and absence of phospholipid
    • Perugini MA, Schuck P, Howlett GJ. 2000. Self-association of human apolipoprotein E3 and E4 in the presence and absence of phospholipid. J Biol Chem 275:36758-36765.
    • (2000) J Biol Chem , vol.275 , pp. 36758-36765
    • Perugini, M.A.1    Schuck, P.2    Howlett, G.J.3
  • 40
    • 0032951957 scopus 로고    scopus 로고
    • Amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: Relevance to Alzheimer's disease
    • Pillot T, Goethals M, Najib J, Labeur C, Lins L, Chambaz J, Brasseur R, Vandekerckhove J, Rosseneu M. 1999. β-Amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease. J Neurochem 72:230-237.
    • (1999) J Neurochem , vol.72 , pp. 230-237
    • Pillot, T.1    Goethals, M.2    Najib, J.3    Labeur, C.4    Lins, L.5    Chambaz, J.6    Brasseur, R.7    Vandekerckhove, J.8    Rosseneu, M.9
  • 41
    • 0023280054 scopus 로고
    • Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B, E (LDL) receptors in the brain
    • Pitas RE, Boyles JK, Lee SH, Hui D, Weisgraber KH. 1987a. Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B, E (LDL) receptors in the brain. J Biol Chem 262:14352-14360.
    • (1987) J Biol Chem , vol.262 , pp. 14352-14360
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3    Hui, D.4    Weisgraber, K.H.5
  • 42
    • 0023080585 scopus 로고
    • Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E containing lipoproteins
    • Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW. 1987b. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E containing lipoproteins. Biochim Biophys Acta 917:148-161.
    • (1987) Biochim Biophys Acta , vol.917 , pp. 148-161
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3    Foss, D.4    Mahley, R.W.5
  • 43
    • 3242656580 scopus 로고    scopus 로고
    • Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins
    • Saito H, Lund-Katz S, Phillips MC. 2004. Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins. Prog Lipid Res 43:350-380.
    • (2004) Prog Lipid Res , vol.43 , pp. 350-380
    • Saito, H.1    Lund-Katz, S.2    Phillips, M.C.3
  • 46
    • 0010731311 scopus 로고
    • Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells
    • Snipes GJ, McGuire CB, Norden JJ, Freeman JA. 1986. Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells. Proc Natl Acad Sci USA 83:1130-1134.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1130-1134
    • Snipes, G.J.1    McGuire, C.B.2    Norden, J.J.3    Freeman, J.A.4
  • 48
    • 0017795758 scopus 로고
    • Fluorescence energy transfer as a spectroscopic ruler
    • Stryer L. 1978. Fluorescence energy transfer as a spectroscopic ruler. Annu Rev Biochem 47:819-846.
    • (1978) Annu Rev Biochem , vol.47 , pp. 819-846
    • Stryer, L.1
  • 50
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. 2002. Nature 416:535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 51
    • 0029844205 scopus 로고    scopus 로고
    • Human apolipoprotein E: The Alzheimer's disease connection
    • Weisgraber KH, Mahley RW. 1996. Human apolipoprotein E: the Alzheimer's disease connection. FASEB J 10:1485-1494.
    • (1996) FASEB J , vol.10 , pp. 1485-1494
    • Weisgraber, K.H.1    Mahley, R.W.2
  • 52
    • 0028146969 scopus 로고
    • Lipoproteins, neurobiology, and Alzheimer's disease: Structure and function of apolipoprotein E
    • Weisgraber KH, Pitas RE, Mahley RW. 1994. Lipoproteins, neurobiology, and Alzheimer's disease: structure and function of apolipoprotein E. Curr Opin Struct Biol 4:507-515.
    • (1994) Curr Opin Struct Biol , vol.4 , pp. 507-515
    • Weisgraber, K.H.1    Pitas, R.E.2    Mahley, R.W.3
  • 53
    • 0027186135 scopus 로고
    • Discrete C-terminal segments of apolipoprotein e mediate lipoprotein association and protein oligomerization
    • Westerlund JA, Weisgraber KH. 1993. Discrete C-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization. J Biol Chem 268:15745-15750.
    • (1993) J Biol Chem , vol.268 , pp. 15745-15750
    • Westerlund, J.A.1    Weisgraber, K.H.2
  • 54
    • 0023900109 scopus 로고
    • Human apolipoprotein E3 in solution I. Evidence for two structural domains
    • Wetterau JR, Aggerbeck LP, Rall SC Jr, Weisgraber KH. 1988. Human apolipoprotein E3 in solution I. Evidence for two structural domains. J Biol Chem 263:6240-6248.
    • (1988) J Biol Chem , vol.263 , pp. 6240-6248
    • Wetterau, J.R.1    Aggerbeck, L.P.2    Rall Jr., S.C.3    Weisgraber, K.H.4
  • 55
    • 0025860481 scopus 로고
    • Three-dimensional structure of the LDL receptor binding domain of human apoE
    • Wilson C, Wardell MR, Weisgraber KH, Mahley RH, Agard DA. 1991. Three-dimensional structure of the LDL receptor binding domain of human apoE. Science 252:1817-1822.
    • (1991) Science , vol.252 , pp. 1817-1822
    • Wilson, C.1    Wardell, M.R.2    Weisgraber, K.H.3    Mahley, R.H.4    Agard, D.A.5
  • 56
    • 0027970307 scopus 로고
    • Acceleration of Alzheimer's fibril formation by apolipoprotein e in vitro
    • Wisniewski T, Castano EM, Golabek A, Vogel T, Frangione B. 1994. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am J Pathol 145:1030-1035.
    • (1994) Am J Pathol , vol.145 , pp. 1030-1035
    • Wisniewski, T.1    Castano, E.M.2    Golabek, A.3    Vogel, T.4    Frangione, B.5
  • 57
    • 0026542786 scopus 로고
    • Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid
    • Wisniewski T, Frangione B. 1992. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 135:235-238.
    • (1992) Neurosci Lett , vol.135 , pp. 235-238
    • Wisniewski, T.1    Frangione, B.2


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