Molecular pathogenesis of cervical cancer;Molekulare pathogenese des zervixkarzinoms und seiner vorstufen

Pathologe

Volumn 26, Issue 4, 2005, Pages 283-290

  Trunk, M J ^a   Wentzensen, N ^b   Von Knebel Doeberitz, M ^b,c  

^a MTM Laboratories AG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cervical carcinoma; Cervical intraepithelial neoplasia; Human papillomavirus; Oncogenes; p16 INK4a

Indexed keywords

PROTEIN E6; PROTEIN E7; PROTEIN P16INK4A;

ANEUPLOIDY; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL STRUCTURE; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; DISEASE COURSE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; MOLECULAR DYNAMICS; PATHOGENESIS; PROTEIN EXPRESSION; REVIEW; UTERINE CERVIX CANCER; VIRUS INFECTION; VIRUS VIRULENCE; WART VIRUS;

CELL CYCLE; CELL DIFFERENTIATION; FEMALE; HUMANS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; TUMOR VIRUS INFECTIONS; UTERINE CERVICAL NEOPLASMS;

EID: 21844452693     PISSN: 01728113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00292-005-0763-4     Document Type: Review

References (35)

1. Brake T, Connor JP, Petereit DG, Lambert PF (2003) Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Cancer Res 63:8173-8180
2. Casas-Cordero M, Morin C, Roy M et al. (1981) Origin of the koilocyte in condylomata of the human cervix: ultrastructural study. Acta Cytol 25:383-392
3. De Villiers EM, Fauquet C, Broker TR et al. (2004) Classification of papillomaviruses. Virology 324:17-27
4. Duensing S, Münger K (2004) Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins. Int J Cancer 109:157-162
5. (INK4a) and hybrid capture 2 human papillomavirus testing for high-grade cervical intraepithelial neoplasia. Am J Clin Pathol 122:894-901
6. Ho GY, Bierman R, Beardsley L et al. (1998) Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 338:423-428
7. INK4a are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol 25:884-891
8. Khleif SN, DeGregori J, Yee CL et al. (1996) Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A 93:4350-4354
9. Klaes R, Woerner SM, Ridder R et al. (1999) Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 59:6132-6136
10. INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 92:276-284
11. INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 26:1389-1399
12. Koutsky L (1997) Epidemiology of genital human papillomavirus infection. Am J Med 102:3-8
13. Longworth MS, Laimins LA (2004) Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev 68:362-372
14. Luft F, Klaes R, Nees M et al. (2001) Detection of integrated papillomavirus sequences by ligation-mediated PCR (DIPS-PCR) and molecular characterization in cervical cancer cells. Int J Cancer 92:9-17
15. Mantovani F, Banks L (2001) The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 20:7874-7887
16. Middleton K, Peh W, Southern S et al. (2003) Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers. J Virol 77:10186-10201
17. Münger K, Basile JR, Duensing S et al. (2001) Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Oncogene 20:7888-7898
18. Munoz N, Bosch FX, Castellsague X et al. (2004) Against which human papillomavirus types shall we vaccinate and screen? The international perspective. Int J Cancer 111:278-285
19. Munoz N, Bosch FX, de Sanjose S et al. (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518-527
20. INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immunocytochemical correlations. Am J Surg Pathol 27:187-193
21. INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri. Virchows Arch 445:616-620
22. Papanicolaou GN, Traut HF (1997) The diagnostic value of vaginal smears in carcinoma of the uterus. 1941. Arch Pathol Lab Med 121:211-224
23. Parkin DM, Bray FI, Devesa SS (2001) Cancer burden in the year 2000. The global picture. Eur J Cancer 37 [Suppl 8]:S4-66
24. Richardson H, Kelsall G, Tellier P et al. (2003) The natural history of type-specific human papillomavirus infections in female university students. Cancer Epidemiol Biomarkers Prev 12:485-490
25. Rosenfeld WD, Rose E, Vermund SH et al. (1992) Follow-up evaluation of cervicovaginal human papillomavirus infection in adolescents. J Pediatr 121:307-311
26. Sano T, Oyama T, Kashiwabara K et al. (1998) Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 153:1741-1748
27. Solomon D, Schiffman M, Tarone R (2001) Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial. J Natl Cancer Inst 93:293-299
28. Stanley M (2003) Genital human papillomavirus infections - current and prospective therapies. J Natl Cancer Inst Monogr, Chapter 17:117-124
29. Tavassoli F, Devilee P (eds) (2003) World Health Organization Classification of Tumours. Pathology and genetics of tumours of the breast and female genital organs. IARC, Lyon
30. INK4a-positive cells in cervical cytology samples. Acta Cytol 48:771-782
31. INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev 13:1355-1360
32. Wentzensen N, Vinokurova S, von Knebel Doeberitz M (2004) Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res 64:3878-3884
33. Yoon CS, Kim KD, Park SN, Cheong SW (2001) alpha(6) integrin is the main receptor of human papillomavirus type 16 VLP. Biochem Biophys Res Commun 283:668-673
34. Yoshida T, Fukuda T, Sano T et al. (2004) Usefulness of liquid-based cytology specimens for the immunocytochemical study of p16 expression and human papillomavirus testing: a comparative study using simultaneously sampled histology materials. Cancer 102:100-108
35. Zur Hausen H (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2:342-350