Modification of epileptiform discharges in neocortical neurons following glutamate uptake inhibition

Epilepsia

Volumn 46, Issue SUPPL. 5, 2005, Pages 129-133

  Campbell, Susan ^a   Hablitz, John J ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Cortical dysplasia; Epilepsy; Glutamate uptake; Neocortex; TBOA

Indexed keywords

3 BENZYLOXYASPARTIC ACID; AMINO ACID TRANSPORTER; ASPARTIC ACID DERIVATIVE; BICUCULLINE; GLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CORTICAL DYSPLASIA; DEPOLARIZATION; DOSE RESPONSE; EPILEPSY; EPILEPTIC DISCHARGE; NEOCORTEX; NERVE CELL EXCITABILITY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ASPARTIC ACID; BICUCULLINE; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; FREEZING; GLUTAMATES; HIPPOCAMPUS; NEOCORTEX; PATCH-CLAMP TECHNIQUES; PREFRONTAL CORTEX; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE;

EID: 21844443810     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2005.01020.x     Document Type: Conference Paper

References (34)

1. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001;65:1-105.
2. +-dependent glutamate uptake in rat hippocampal astrocyte cultures. J Neurochem 1996;67:277-86.
3. Springer JE, Azbill RD, Mark RJ, Begley JG, Waeg G, Mattson MP. 4-Hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake. J Neurochem 1997;68:2469-76.
4. Lin CL, Bristol LA, Jin L, et al. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron 1998;20:589-602.
5. Rossi DJ, Oshima T, Attwell D. Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature 2000;403:316-21.
6. Miller HP, Levey AI, Rothstein JD, Tzingounis AV, Conn PJ. Alterations in glutamate transporter protein levels in kindling-induced epilepsy. J Neurochem 1997;68:1564-70.
7. Gorter JA, Van Vliet EA, Proper EA, et al. Glutamate transporters alterations in the reorganizing dentate gyrus are associated with progressive seizure activity in chronic epileptic rats. J Comp Neurol 2002;442:365-77.
8. Ueda Y, Doi T, Tokumaru J, et al. Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. J Neurochem 2001;76:892-900.
9. Tanaka K, Watase K, Manabe T, et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 1997;276:1699-702.
10. Rothstein JD, Dykes-Hoberg M, Pardo CA, et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitatory and clearance of glutamate. Neuron 1996;16:675-86.
11. Isaacson JS, Nicoll RA. The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus. J Neurophysiol 1993;70:2187-91.
12. Barbour B, Keller BU, Llano I, Many A. Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar purkinje cells. Neuron 1994;12:1331-43.
13. Kinney GA, Overstreet LS, Slater NT. Prolonged physiological entrapment of glutamate in the synaptic cleft of cerebellar unipolar brush cells. J Neurophysiol 1997;78:1320-33.
14. Kidd FL, Isaac JTR. Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance. J Neurophysiol 2001;86:1139-48.
15. Avoli M, Mattia D, Siniscalchi P, Perreault P, Tomaiuolo F. Pharmacology and electrophysiology of a synchronous GABA-mediated potential in the human neocortex. Neuroscience 1994;62:655-66.
16. Ayala GF, Matsumoto H, Gumnit RJ. Excitability changes and inhibitory mechanisms in neocortical neurons during seizures. J Neurophysiol 1970;33:73-85.
17. Mattia D, Olivier A, Avoli M. Seizure-like discharges recorded in human dysplastic neocortex maintained in vitro. Neurology 1995;45:1391-5.
18. Gutnick MJ, Connors BW, Prince DA. Mechanisms of neocortical epileptogenesis in vitro. J Neurophysiol 1982;48:1321-35.
19. Hablitz JJ. Spontaneous ictal-like discharges and sustained potential shifts in the developing rat neocortex. J Neurophysiol 1987;58:1052-65.
20. Zhang WQ, Hudson PM, Sobotka TJ, Hong JS, Tilson HA. Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after the development of kindling. Brain Res 1991;540:315-8.
21. During MJ, Spencer DD. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 1993;341:1607-10.
22. Overstreet LS, Kinney GA, Liu YB, Billups D, Slater NT. Glutamate transporters contribute to die time course of synaptic transmission in cerebellar granule cells. J Neurosci 1999;19:9663-73.
23. Shimamoto K, LeBrun B, Yasuda-Kamatani Y, et al. DL-threo-β- Benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol 1998;53:195-201.
24. Campbell SL, Hablitz JJ. Glutamate uptake inhibition enhances epileptiform activity in rat neocortex. Epilepsia 2001;42(suppl 7):95-6.
25. DeFazio RA, Hablitz JJ. Alterations in NMDA receptors in a rat model of cortical dysplasia. J Neurophysiol 2000;83:315-21.
26. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 3 Ed. Academic Press, San Diego, 1997.
27. Jacobs KM, Gutnick MJ, Prince DA. Hyperexcitability in a model of cortical maldevelopment. Cereb Cortex 1996;6:514-23.
28. Jacobs KM, Hwang BJ, Prince DA. Focal epileptogenesis in a rat model of polymicrogyria. J Neurophysiol 1999;81:159-73.
29. Luhmann HJ, Raabe K. Characterization of neuronal migration disorders in neocortical structures: I. Expression of epileptiform activity in an animal model. Epilepsy Res 1996;26:67-74.
30. Jabaudon D, Shimamoto K, Yasuda-Kamatani Y, Scanziani M, Gähwiler BH, Gerber U. Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc Natl Acad Sci USA 1999;96:8733-8.
31. Himi T, Ikeda M, Yashuhara T, Murota S. Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons. J Neurosci Res 2002;71:679-88.
32. Bonde C, Sarup A, Schousboe A, Gegelashvili G, Zimmer J, Noraberg J. Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) during physiological and ischemia-like conditions. Neurochem Int 2003;43:371-80.
33. Izumi Y, Shimamoto K, Benz AM, Hammerman SB, Olney JW, Zorumski CF. 2002. Glutamate transporters and retinal excitotoxicity. Glia 2002;39:58-68.
34. Mathews GC, Diamond JS. Neuronal glutamate uptake contributes to GABA synthesis and inhibitory synaptic strength. J Neurosci 2003;23:2040-8.