Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 5, 2000, Pages 1705-1712

  Crouser, Elliott D ^a   Julian, Mark W ^a   Weinstein, David M ^a   Fahy, Ruairi J ^a   Bauer, John A ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAT; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENDOTOXEMIA; ILEUM MUCOSA; INTESTINE INJURY; MALE; MICROCIRCULATION; MITOCHONDRION; MULTIPLE ORGAN FAILURE; NECROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TISSUE OXYGENATION;

EID: 0034067422     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.5.9907043     Document Type: Article

References (44)

1. 1. Knaus, W. A., and D. P. Wagner. 1989. Multiple systems organ failure: epidemiology and prognosis. Crit. Care Clin. 5:221-232.
2. 2. Deitch, E. A., R. D. Specian, and R. D. Berg. 1991. Endotoxin-induced bacterial translocation and mucosal permeability: role of xanthine oxidase, complement activation, and macrophage products. Crit. Care Med. 19:785-791.
3. 3. Nieuwenhuijzen, G. A., E. A. Deitch, and R. J. Goris. 1996. The relationship between gut-derived bacteria and the development of the multiple organ dysfunction syndrome. J. Anatomy 189:537-548.
4. 4. Hiramatsu, M., R. S. Hotchkiss, I. E. Karl, and T. G. Buchman. 1997. Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 7:247-253.
5. 5. Bohlinger, I., M. Leist, F. Gantner, S. Angermuller, G. Tiegs, and A. Wendel. 1996. DNA fragmentation in mouse organs during endotoxic shock. Am. J. Pathol. 149:13871-13893.
6. 6. Stamler, J. S., D. J. Singel, and J. Loscalzo. 1992. Biochemistry of nitric oxide and its redox-activated forms. Science 258:1898-1901.
7. 7. Salzman, A. L. 1995. Nitric oxide in the gut. New Horizons 3:352-364.
8. 8. Gianotti, L., J. W. Alexander,T. Pyles, and R. Fukushima. 1993. Argininesupplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance: the role of nitric oxide. Ann. Surg. 217:644-653.
9. 9. Ford, H., S. Watkins, K. Reblock, and M. Rowe. 1997. The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis. J. Pediatr. Surg. 32:275-282.
10. 10. Parrat, J. R. 1998. Nitric oxide in sepsis and endotoxaemia. J. Antimicrob. Ther. 41:S31-S39.
11. 11. Chen, K., M. Inoue, and A. Okada. 1996. Expression of inducible nitric oxide synthase mRNA in digestive tissues after endotoxin and its role in intestinal injury. Biochem. Biophys. Res. Commun. 224:703-708.
12. 12. Unno, N., H. Wang, M. J. Menconi, S. H. Tytgat. V. Larkin, M. Smith, M. J. Morin, A. Chavez, R. A. Hodin, and M. P. Fink. 1997. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 113:1246-1257.
13. 13. Chamulitrat, W., N. V. Skrepnik, and J. J. Spitzer. 1996. Endotoxin-induced oxidative stress in the rat small intestine: role of nitric oxide. Shock 5:217-222.
14. 14. Sandoval, M., X. Liu, E. E. Mannick, D. A. Clark, and M. J. Miller. 1997. Peroxynitrite-induced apoptosis in human intestinal epithelial cells is attenuated by mesalamine. Gastroenterology 113:1480-1488.
15. 15. Beckman, J. S., and W. H. Koppenol. 1996. Nitric oxide, superoxide and peroxynitrite: the good, the bad, and the ugly. Am. J. Physiol. 271: C1427-C1437.
16. 16. Pryor, W. A., and G. L. Squadrito. 1995. The chemistry of peroxynitrite: a product from reaction of nitric oxide with superoxide. Am. J. Physiol. 268:L699-L722.
17. 2 alterations induced by endotoxin correlate with severity of mitochondrial injury. Am. J. Respir. Crit. Care Med. 160:1347-1353.
18. 2 alterations do not correlate with the severity of ileal injury. J. Crit. Care 12:83-91.
19. 3 in vivo. J. Appl. Physiol. 43:858-872.
20. 20. Kitai, T., A. Tanaka, A. Tokuka, K. Tanaka, Y. Yamaoka, K. Ozawa, and K. Hirao. 1993. Quantitative detection of hemoglobin saturation in the liver with near-infrared spectroscopy. Hepatology 18:926-936.
21. 21. Trump. B. F., I. K. Berezesky, K. U. Laiho, A. R. Osornio, W. J. Mergner, and M. W. Smith. 1980. The role of calcium in cell injury: a review. Scanning Electron Microsc. 2:437-462.
22. 22. Negoescu, A., P. Lorimier, F. Labat-Moleur, C. Drouet, C. Robert, C. Guillermet, C. Brambilla, and E. Brambilla. 1996. In situ apoptotic cell labeling by the TUNEL method: improvement and evaluation on cell preparations. J. Histochem. Cytochem. 44:959-968.
23. 23. Robertson, F. M., B. W. Long, K. L. Tober, M. S. Ross, and T. M. Oberyszym. 1996. Gene expression and cellular sources of inducible nitric oxide synthase during tumor promotion. Carcinogenesis 17:2053-2059.
24. 24. Russ, J. C. 1998. Segmentation and thresholding. In J. C. Russ, editor. The Image Processing Handbook, 3rd ed. C.R.C. Press, Boca Raton. 371-430.
25. 25. Sokal, R. R., and F. J. Rohlf. 1981. Biometry, 2nd ed. W. H. Freeman, New York. 242-262, 324-344,606-616.
26. 26. VanderMeer, T. J., H. Wang, and M. P. Fink. 1995. Endotoxin causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic model of septic shock. Crit. Care Med. 22:1217-1226.
27. 27. Hayes, M. A., A. C. Timmins, E. H. S. Yau, M. Palazzo, C. J. Hinds, and D. Watson. 1994. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N. Engl. J. Med. 330:1717-1722.
28. 28. Gattinoni, L., L. Brazzi, P. Pelosi, R. Latini, G. Tognoni, A. Pesenti, and R. Fumagalli. 1995. A trial of goal-oriented hemodynamic therapy in critically ill patients. N. Engl. J. Med. 333:1025-1032.
29. 29. Taylor, D. E. 1998. Revving the motor of multiple organ disfunction syndrome: gut dysfunction in ARDS and multiorgan failure. Respir. Care Clin. North Am. 4:611-631.
30. 30. Boekstegers, P., S. Weidenhofer, T. Kapsner, and K. Werdan. 1994. Skeletal muscle partial pressure of oxygen in patients with sepsis. Circ. Shock 33:17-25.
31. 31. Revelly, J. P., T. Ayuse, N. Brienza, H. E. Fessler, and J. L. Robotham. 1996. Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit. Care Med. 24:1345-1351.
32. 32. Hotchkiss, R. S., P. E. Swanson, J. P. Cobb, A. Jacobson, T. G. Buchman, and I. E. Karl. 1997. Apoptosis in lymphoid and parenehymal cells during sepsis: findings in normal and T-and B-cell-deficient mice. Crit. Care Med. 25:1298-1307.
33. 33. Fukuyama, N., Y. Takebayashi, M. Hida, H. Ishida, K. Ichimori, and H. Nakazawa. 1997. Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock. Free Rad. Biol. Med. 22:771-774.
34. 34. Wyllie, A. H., J. F. R. Kerr, and A. R. Curie. 1980. Cell death: the significance of apoptosis. In G. H. Bourne, F. J. Danielli, and K. W. Jeon, editors. International Review of Cytology, Vol. 68. Academic Press, New York. 251-306.
35. 35. Morin, M. J., N. Unno, R. A. Hodin, and M. P. Fink. 1998. Differential expression of inducible nitric oxide synthase messenger RNA along the longitudinal and crypt-villus axes of the intestine in endotoxemic rats. Crit. Care Med. 26:1258-1264.
36. 36. Zingarelli, B., L. Virag, A. Szabo, S. Cuzzocrea, A. L. Salzman, and C. Szabo. 1998. Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide sythase. Int. J. Mol. Med. 1:787-795.
37. 2 extraction during endotoxemia: role of nitric oxide synthesis. Am. J. Respir. Crit. Care Med. 151:107-115.
38. 38. Faggioni, R., S. Gatti, M. T. Demitri, R. Delgado, B. Echtenacher, P. Gnoochi, H. Heremans, and P. Ghezzi. 1994. Role of xanthine-oxidase and reactive oxygen intermediates in LPS-induced and TNF-induced pulmonary edema. J. Lab. Clin. Med. 123:394-399.
39. 39. Wang, W., Y. Suzuki, T. Tanigaki, D. R. Rank, and T. A. Raffin. 1994. Effect of the NADPH oxidase inhibitor apocynin on septic lung injury in guinea pigs. Am. J. Respir. Crit. Care Med. 150:1449-1452.
40. 2+ and phosphorylation. Biochem. J. 311:189-195.
41. 41. Lee, F. Y., Y. Li, H. Zhu, S. Yang. H. Z. Lin, M. Trush, and A. M. Diehl. 1999. Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regeneratc ing mouse liver. Hepatology 29:677-687.
42. 2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s). J. Pharmacol. Exp. Ther. 274:427-436.
43. 43. Strand, O. A., K. A. Kirkenboen, and K. E. Giercksky. 1997. Inhibition of nitric oxide synthase doses not affect survival in a rat model of abdominal sepsis. Scand, J. Clin. Lab. Invest. 57:105-109.
44. 44. Spain, D. A., M. A. Wilson, M. F. Bar-Natan, and R. N. Garrison. 1994. Nitric oxide synthase inhibition aggravates intestinal microvascular vasoconstriction and hypoperfusion of bacteremia. J. Trauma 36: 720-725.