Prior exposure to indole-3-carbinol decreases the incidence of specific cyclophosphamide-induced developmental defects in mice

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 74, Issue 3, 2005, Pages 261-267

  Bailey, Melissa M ^a   Sawyer, Robert D ^a   Behling, Jeremy E ^a   Boohaker, Jonathan G ^a   Hicks, Justin G ^a   O'Donnell, Molly A ^a   Stringer, Kelli R ^a   Rasco, Jane F ^a   Hood, Ronald D ^a,b  

^a UNIVERSITY OF ALABAMA   (United States)

^b Ronald D Hood and Associates   (United States)

Author keywords

Glucobrassicin; Malformations; Mice; Teratogenicity

Indexed keywords

3 INDOLEMETHANOL; CYCLOPHOSPHAMIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FETUS; FETUS MALFORMATION; FOOT MALFORMATION; GESTATION PERIOD; LIMB MALFORMATION; MALE; MOUSE; NONHUMAN; ORGANOGENESIS; PREGNANCY; PRIORITY JOURNAL; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CYCLOPHOSPHAMIDE; FEMALE; FETAL DEVELOPMENT; FETUS; INDOLES; MALE; MICE; MICE, INBRED STRAINS; MUTAGENS; PREGNANCY;

ANIMALIA; MAMMALIA;

EID: 21744454669     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20046     Document Type: Article

References (43)

1. Agrawal RC, Kumar S. 1999. Prevention of chromosomal aberration in mouse bone marrow by indole-3-carbinol. Toxicol Lett 106:137-141.
2. Anderton MJ, Manson MM, Verschoyle RD, Gescher A, Lamb JH, Farmer PB, Steward WP, Williams ML. 2004. Pharmacokinetics and tissue distribution of indole-3-carbinol and its acid condensation products after oral administration to mice. Clin Cancer Res 10:5233-5241.
3. Arnao MB, Sanchez-Bravo J, Acosta M. 1996. Indole-3-carbinol as a scavenger of free radicals. Biochem Mol Biol Int 39:1125-1134.
4. Auborn KJ, Fan S, Rosen EM, Goodwin L, Chandraskaren A, Williams DE, Chen D, Carter TH. 2003. Indole-3-Carbinol is a negative regulator of estrogen. J Nutr 133:2470S-2475S.
5. Bogaards JJP, Verhagen H, Willems MI, van Poppel G, van Bladeren PJ. 1994. Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma. Carcinogenesis 15:1073-1075.
6. Bradlow HL, Michnovicz JJ, Halper M, Miller DG, Wong GY, Osborne MP. 1994. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 3:591-595.
7. Bradlow HL, Michnovicz JJ, Telang NT, Osborne MP. 1991. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12:1571-1574.
8. Brignall MS. 2001. Prevention and treatment of cancer with indole-3-carbinol. Altern Med Rev 6:580-589.
9. Broadbent TA, Broadbent HS. 1998a. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole. [Part I]. Curr Med Chem 5:337-352.
10. Broadbent TA, Broadbent HS. 1998b. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole. [Part II]. Curr Med Chem 5:469-491.
11. Brock N, Stekar J, Pohl J, Niemeyer U, Scheffler G. 1979. Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sulfosfamide. Arzneimittelforschung 29:659-661.
12. Chen D, Qi M, Auborn KJ, Carter TH. 2001. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-trangenic preneoplastic cervical epithelium. J Nutr 131:3294-3302.
13. Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. 2001. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene 20:2927-2936.
14. 1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J Biol Chem 273:3838-3847.
15. Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF, Firestones GF. 1999. Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells. Cancer Res 59:1244-1251.
16. Ge X, Yannai S, Rennert G, Gruener N, Fares FA. 1996. 3,3″-Diindolyl-methane induces apoptosis in human cancer cells. Biochem Biophys Res Commun 228:153-158.
17. Gomes-Carneiro MR, De-Oliveira ACAX, De-Carvalho IBA, Souza CAM, Kuriyama SN, Paumgartten FJR. 2003. Inhibition of cyclophosphamide-induced teratogenesis by β-ionine. Toxicol Lett 138: 205-213.
18. Greenaway JC, Fantal AG, Shepard TH, Juchau MR. 1982. The in vitro teratogenicity of cyclophosphamide in rat embryos. Teratology 25:335-343.
19. Hales BF. 1982. Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein. Cancer Res 42:3016-3021.
20. Han S-Y, Shin J-H, Kwon SC, Kang MO, Lee YM, Kim PG, Yang M, Park KL, Jang SJ. 1995. Effects of enzyme inducers and glutathione (GSH) on the embryotoxicity of cyclophosphamide (CP) in cultured rat embryos. Int Toxicol 7:12.
21. Huang D, Hales BF. 2002. Roles of caspases in murine limb bud cell death induced by 4-hydroperoxycyclophosphamide, and activated analog of cyclophosphamide. Teratology 66:288-299.
22. Larsen-Su SA, Williams DE. 2001. Transplacental exposure to indole-3-carbinol induces sex-specific expression of CYP1A1 and CYP1B1 in the liver of Fischer 344 neonatal rats. Toxicol Sci 64:162-168.
23. Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. 2003. Plant-derived 3,3′-diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem 278:21136-21145.
24. Li Y, Li X, Sarkar FH. 2003. Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis. J Nutr 133:1011-1019.
25. Marty MS, Zablotny CL, Stebbins KE, Woolhiser M, Andrus AK, Brzak KA, Kan HL, Carney EW. 2003. An integrated study design to evaluate reproductive, immune and nervous system effects of indole-3-carbinol (I3C) in CD rats exposed during gestation and lactation. Birth Defects Res Part A Clin Mol Teratol 67:351.
26. Mehta JR, Przybylski M, Ludlum DB. 1980. Alkylation of guanosine and deoxyguanosine by phosphoramide mustard. Cancer Res 40: 4183-4186.
27. Mirkes PE. 1985. Cyclophosphamide teratogenesis: a review. Teratog Carcinog Mutagen 5:75-88.
28. 3H] cyclophosphamide by rat embryos in vitro. Teratology 31:373-380.
29. Nachshon-Kedmi M, Yannai S, Haj A, Fares FA. 2003. Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol 41:745-752.
30. Nijhoff WA, Grubben MJAL, Nagengast FM, Jansen JBMJ, Verhagen H, van Poppel G, Peters WHM. 1995a. Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans. Carcinogenesis 16:2125-2128.
31. Nijhoff WA, Mulder TPJ, Verhagen H, van Poppel G, Peters WHM. 1995b. Effects of consumption of Brussels sprouts on plasma and urinary glutathione S-transferase class-α and -π in humans. Carcinogenesis 16:995-957.
32. Rosen CA, Woodson GE, Thompson JW, Hengesteg AP, Bradlow HL. 1998. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 118:810-815.
33. Schwartz PS, Waxman DJ. 2001. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol 60:1268-1279.
34. Shertzer HG, Berger ML, Tabor MW. 1988. Intervention in free radical mediated hepatotoxicity and lipid peroxidation by indole-3-carbinol. Biochem Pharmacol 37:333-338.
35. Stankiewicz A, Skrzydlewska E. 2003. Protection against cyclophosphamide-induced renal oxidative stress by amifostine: the role of antioxidative mechanisms. Toxicol Mech Methods 13:301-308.
36. van Iersel MLPS, Verhagen H, van Bladeren PJ. 1999. The role of biotransformation in dietary (anti)carcinogenesis. Mutation Res 443: 259-270.
37. Verhoeven DTH, Verhagen H, Goldbohm RA, van den Brandt P, van Poppel G. 1997. A review of mechanisms underlying anticarcinogenicity by Brassica vegetables. Chem Biol Interact 103:79-129.
38. Wattenberg LW, Loub WD. 1978. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res 38:1410-1413.
39. Webb GN, Byrd RA. 1994. Simultaneous differential staining of cartilage and bone in rodent fetuses: an Alcian blue and alizarin red S procedure without glacial acetic acid. Biotech Histochem 69:181-185.
40. Wortelboer HM, Van der Linden E CM, De Kruif CA, Noordhoek J, Blaauboer BJ, Van Bladeren PJ, Falke HE. 1992. Effects of indole-3-carbinol on biotransformation enzymes in the rat: In vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures. Food Chem Toxicol 30:589-599.
41. Wrabetz E, Peter G, Hohorst HJ. 1980. Does acrolein contribute to the cytotoxicity of cyclophosphamide? J Cancer Res Clin Oncol 95: 119-126.
42. Yu Z, Mahadevan B, Siddens LK, Albershardt DJ, Krueger SK, Louderback M, Baird WM, Williams DE. 2005. Transplacental genotoxicity of dibenzo[a,1)pyrene (DBP) and the effect of indole-3-carbinol (I3C) in the maternal diet. Toxicologist 44:306.
43. Zhang J, Hsu JC, Kinseth MA, Bjeldanes LF, Firestone GL. 2003. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells. Cancer 98:2511-2520.