Cytochrome P4502E1 primes macrophages to increase TNF-α production in response to lipopolysaccharide

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 289, Issue 1 52-1, 2005, Pages

  Cao, Qi ^a   Mak, Ki M ^a   Lieber, Charles S ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diallyl sulfide; Diphenyleneiodonium; Nuclear factor kappaB; Oxidative stress; Reduced nicotinamide adenine dinucleotide phosphate oxidase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALLYL SULFIDE; CD14 ANTIGEN; CYTOCHROME P450 2E1; DIPHENYLIODONIUM SALT; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P47; PROTEIN P67; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME SUBUNIT; GENETIC TRANSFECTION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ALLYL COMPOUNDS; ANIMALS; ANTIGENS, CD14; ANTIOXIDANTS; CATALASE; CYTOCHROME P-450 CYP2E1; ENZYME INHIBITORS; HUMANS; HYDROGEN PEROXIDE; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADPH OXIDASE; NF-KAPPA B; ONIUM COMPOUNDS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; RECEPTORS, CELL SURFACE; SULFIDES; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 21744435549     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00383.2004     Document Type: Article

References (56)

1. Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124:778-789, 2003.
2. Barbior MB. NADPH oxidase: an update. Blood 93: 1464-1476, 1999.
3. Brady JF, Ishizaki H, Fukuto JM, Lin MC, Fadel A, Gapac JM, and Yang CS. Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites. Chem Res Toxicol 4: 642-647, 1991.
4. Cao Q, Mak KM, and Lieber CS. Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-α generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-κB. Biochem Biophys Res Comm 294: 849-853, 2002.
5. Cao Q, Mak KM, and Lieber CS. Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-α generation in Kupffer cells of ethanol-fed rats. Biochem Biophys Res Comm 299: 459-464, 2002.
6. Cao Q, Mak KM, and Lieber CS. Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells. J Biol Chem 279: 4292-4304, 2004.
7. Carter WO, Narayanan PK, and Robinson JP. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. J Leuko Biol 55: 253-258, 1994.
8. Cederbaum AI, Wu D, Mari M, and Bai J. CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med 31: 1539-1543, 2001.
9. Chow JC, Young DW, Golenbock DT, Christ WJ, and Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274: 10689-10692, 1999.
10. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, and Lee JC. SB-203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stress and interleukin-1. FEBS Lett 364: 229-233, 1995.
11. DeLeo FR, Renee J, McCormick S, Nakamura M, Apicella M, Weiss JP, and Nauseef WM. Neutrophils exposed to bacterial lipopolysacchride upregulate NADPH oxidase assembly. J Clin Invest 101: 455-463, 1998.
12. Doussiere J and Vignais PV. Diphenylene iodonium as an inhibitor of the NADPH oxidase complex of bovine neutrophils. Factors controlling the inhibitory potency of diphenylene iodonium in a cell-free system of oxidase activation. Eur J Biochem 208: 61-71, 1992.
13. Dudley DT, Pang L, Decker SJ, Bridges AJ, and Saltiel AR. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92: 7686-7689, 1955.
14. phox by p38 and ERK but not by JNK. Arch Biochem Biophys 334: 395-400, 1996.
15. Garcia J, Lemercier B, Roman-Roman S, and Rawadi G. A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF- B activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways. J Biol Chem 273: 34391-34398, 1998.
16. Han J, Lee JD, Tobias PS, and Ulevitch RJ. Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J Biol Chem 268: 25009-25014, 1993.
17. Hancock JT and Jones OTG. The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages. Biochem J 242: 103-107, 1987.
18. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, and Akira S. Toll-like receptor 4(TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 749-3752, 1999.
19. Hsu HY and Wen MH. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol Chem 277: 22131-22139, 2002.
20. Kishore R, Hill JR, McMullen MR, Frenkel J, and Nagy LE. ERK1/2 and Egr-1 contribute to increased TNF- production in rat Kupffer cells after chronic ethanol feeding. Am J Physiol Gastrointest Liver Physiol 282: G6-G15, 2002.
21. Kishore R, McMullen MR, and Nagy LE. Stabilization of tumor necrosis factor mRNA by chronic ethanol. Role of A + U-rich elements and p38 mitogen-activated protein kinase signaling pathway. J Bolo Chem 276: 41930-41937, 2001.
22. Koivisto T, Mishin VM, Mak KM, Cohen A, and Lieber CS. Induction of cytochrome P-4502E1 by ethanol in rat Kupffer cells. Alcohol: Clin Exp Res 20: 207-212, 1966.
23. Kono H, Bradford BU, Yin M, Sulik KK, Koop DR, Peters JM, Gonzalez FJ, McDonald T, Dikalova A, Kadiiska MB, Mason RP, and Thurman RG. CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol Gastrointest Liver Physiol 277: G1259-G1267, 1999.
24. Kono H, Rusyn I, Uesugi T, Yamashina S, Connor HD, Dikalova A, Mason RP, and Thurman RG. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol 280: G1005-G1012, 2001.
25. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, and Thurman RG. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 106: 867-872, 2000.
26. Koop DR, Chernosk A, and Brass EP. Identification and induction of cytochrome P450 2E1 in rat Kupffer cells. J Pharmocol Exp Therap 258: 1072-1076, 1991.
27. Kuypers FA, van den Berg JJM, Schalkwijk C, Roelofsen B, and Op den Kamp JAF. Parinaric acid as a sensitive fluorescent probe for the determination of lipid peroxidation. Biochem Biophys Acta 921: 266-274, 1987.
28. Landmann R, Scherer F, Schmann R, Link S, Sansano S, Zimmerli W. LPS directly induces oxygen radical production in human monocytes via LPS-binding protein and CD14. J Leukoc Biol 57: 440-449, 1995.
29. Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in marine nonalcoholic steatohepatitis. J Clin invest 105: 1067-1075, 2002.
30. Lieber CS. Cytochrome P-4502E1: Its physiological and pathological role. Physiol Rev 77: 517-543, 1977.
31. Liu H, Jones BE, Bradham C, and Czaja MJ. Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-α. Am J Physiol Gastrointest Liver Physiol 282: 0257-0266, 2002.
32. Majander A, Finel M, and Wikstrom M. Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADPH-ubiquinone oxidoreductase (complex I). J Biol Chem 269: 21037-21042, 1994.
33. Morgan K, French S, and Morgan TR. Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. Hepatology 36: 122-134, 2002.
34. Morimoto M, Hagbjork AL, Wan YJY, Fu PC, Clot P, Albano E, Ingelman-Sundberg M, and French SW. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology 21: 1610-1617, 1995.
35. Nakamura Y, Yokoyama H, Sato S, and Ishii H. Major role of cytochrome P450 2E1 in ethanol oxidation by Kupffer cells. Res Commun Alcohol Subst Abuse 20: 15-25, 1999.
36. Nanji AA, Jokelainen K, Rahemetulla A, Miao L, Fogt F, Matsumoto H, Tahan SR, and Su GL. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology 30: 934-943, 1999.
37. Nieto N, Friedman SL, Greenwel P, and Cederbaum AI. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology 30: 987-996, 1999.
38. O'Donnell VB, Tew DG, Jones OTG, and England PJ. Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem J 290: 41-49, 1993.
39. Ou CC, Tsao SM, Lin MC, and Yin MC. Protective action on human LDL against oxidation and glycation by four organosulfur compounds derived from garlic. Lipids 38: 219-224, 2003.
40. Poltorak A, He X, Smirnova I, Liu Van Huffel C MY, Du Birdwell D X, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, and Beutler B. Defective LPS signalling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088, 1998.
41. phox cells, and the levels of superoxide production is exchange factor-dependent. J Biol Chem 277: 19220-19228, 2002.
42. Sanlioglu S, Williams CM, Samavati L, Butler NS, Wang G, McCray PB Jr, Ritchie TC, Hunninghake GW, Zandi E, and Engelhardt JF. Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-secretion through IKK regulation of NF-κB. J Biol Chem 276: 30188-30198, 2002.
43. Sasada M, Pabst MJ, and Johnston RB Jr. Activation of mouse peritoneal macrophages by lipopolysacchride alters the kinetic parameters of the superoxide-producing NADPH oxidase. J Biol Chem 258: 9631-9635, 1983.
44. Schumann RR, Pfeil D, Lamping N, Kirschning C, Scherzing G, Schlag P, Karawajew L, and Herrmann F. Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14. Blood 87: 2805-2814, 1966.
45. Su GL. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 283: G256-G265, 2002.
46. Su GL, Klein RD, Aminlari A, Zhang HY, Steinstraesser L, Alarcon WH, Remick DG, and Wang SC. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 31: 932-936, 2000.
47. 2-generating NADH oxidase in human lung fibroblasts by transforming growth factor. J Biol Chem 270: 30334-30338, 1995.
48. Thurman RG. Mechanisms of Hepatic Toxicity. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol Gastrointest Liver Physiol 275: G605-G611, 1998.
49. Wheeler MD, Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, Gabele E, Rusyn I, Yamashina S, Froh M, Adachi Y, Iimuro Y, Bradford BU, Smutney OM, Connor HD, Mason RP, Goyert SM, Peters JM, Gonzalez FJ, Samulski J, and Thurman RG. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radie Biol Med 31: 1544-1549, 2001.
50. Wickramasinghe SN, Barden G, and Levy L. The capacity of macrophages from different murine tissues to metabolize ethanol and generate an ethanol-dependent non-dialysable cytotoxic activity in vitro. Alcohol Alcohol 22: 31-39, 1987.
51. Wu D, Clejan L, Potter B, and Cederbaum AI. Rapid decrease of cytochrome P-250IIE1 in primary hepatocyte culture and its maintenance by added 4-methylpyrazole. Hepatology 12: 1379-1389, 1990.
52. Wu D and Cederbaum AI. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. J Biol Chem 271: 23914-23919, 1966.
53. Wu D and Cederbaum AI. Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity. J Biol Chem 278: 1115-1124, 2003.
54. Yang CS, Chhabra SK, Hong JY, and Smith TJ. Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. J Nutr 131: 1041S-1045S, 2001.
55. Yin M, Bradford BU, Wheeler MD, Uesugi T, Froh M, Goyert SM, Thurman RG. Reduced early alcohol-induced liver injury in CD-14 deficient mice. J Immunol 166: 4737-4742, 2001.
56. Zhang G and Ghosh S. Toll-like receptor-mediated NF-κB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest 107: 13-19, 2001.