Mice lacking the integrin β5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state

Journal of Bone and Mineral Research

Volumn 20, Issue 1, 2005, Pages 58-66

  Lane, Nancy E ^a,b   Yao, Wei ^a   Nakamura, Mary C ^a,b   Humphrey, Mary Beth ^a,b   Kimmel, Donald ^c   Huang, Xiaozhu ^a   Sheppard, Dean ^a   Ross, F Patrick ^d   Teitelbaum, Steven L ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 knockout; Estrogen deficiency; Mice; Osteoclasts

Indexed keywords

BETA3 INTEGRIN; BETA5 INTEGRIN; CALCITONIN; CATHEPSIN K; ESTROGEN; BETA INTEGRIN; CALCITONIN RECEPTOR; CATHEPSIN; MESSENGER RNA; VITRONECTIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE REMODELING; CELL ACTIVITY; CELL MATURATION; CELL SURVIVAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DENTIN; EX VIVO STUDY; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PROTEIN EXPRESSION; PROTEIN MOTIF; TRABECULAR BONE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; MOUSE MUTANT; MUTATION; PHYSIOLOGY;

ANIMALS; BONE RESORPTION; CATHEPSINS; CELL DIFFERENTIATION; ESTROGENS; FEMALE; GENE EXPRESSION; INTEGRIN ALPHAVBETA3; INTEGRIN BETA CHAINS; INTEGRIN BETA3; MICE; MICE, KNOCKOUT; MUTATION; OSTEOCLASTS; RECEPTORS, CALCITONIN; RNA, MESSENGER;

EID: 21644465509     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2005.20.1.58     Document Type: Article

References (33)

1. Baron R 1999 Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Lippincott Williams & Wilkins, Philadelphia, PA, USA.
2. Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin T, Suda T 1990 Origin of osteoclasts: Mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci USA 87:7260-7264.
3. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176.
4. Horton MA, Taylor ML, Arnett TR, Helfrich MH 1991 Arg-gly-asp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts. Exp Cell Res 195:368-375.
5. Grontos S, Simmons PJ, Graves SE, Rosey PG 2001 Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix. Bone 28:174-181.
6. Grzesik WJ, Robey PG 1994 Bone matrix RCG glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro. J Bone Miner Res 9:487-496.
7. Engleman VW, Nickols GA, Ross FP, Horton MA, Griggs DW, Settle SL, Ruminski PG, Teitelbaum SL 1997 A peptidomimetic antagonist of the av3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J Clin Invest 99:2284-2292.
8. Nakamura I, Tanaka H, Rodan GA, Duong LT 1998 Echistatin inhibits the migration of murine prefusion osteoclasts and the formation of multinucleated osteoclast-like cells. Endocrinology 139:5182-5193.
9. McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Lam J, Novack D, Feng X, Ross FP, Hynes RO, Teitelbaum SL 2000 Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest 105:433-440.
10. Feng X, Novack DV, Faccio R, Ory DS, Aya K, Boyer M, McHugh KP, Ross FP, Teitelbaum SL 2000 A Glanzmann's mutation in β3 integrin specifically impairs osteoclast function. J Clin Invest 107:1137-1144.
11. McLean JW, Vestal DJ, Cheresh DA, Bodary SC 1990 cDNA sequence of the human integrin beta 5 subunit. J Biol Chem 265:17126-17131.
12. Smith JW, Vestal DJ, Irwin SV, Burke TA, Cheresh DA 1990 Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin. J Biol Chem 265:11008-11013.
13. Inoue M, Namba N, Chappel J, Teitelbaum SL, Ross FP 1998 Granulocyte macrophage-colony stimulating factor reciprocally regulates αv-associated integrins on murine osteoclast precursors. Mol Endocrinol 12:1955-1962.
14. Inoue M, Ross FP, Erdmann JM, Abu-Amer Y, Wei S, Teitelbaum SL 1999 Tumor necrosis factor α regulates αvβ5 integrin expression by osteoclast precursors in vitro and in vivo. Endocrinology 141:284-290.
15. Huang XZ, Griffiths M, Wu J, Farese RV Jr, Sheppard D 2000 Normal development, wound healing, and adenovirus susceptibility in β5-deficient mice. Mol Cell Biol 20:755-759.
16. Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, Nakamura M 2004 The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res 19:224-234.
17. d. J Environ Monit 192:447-454.
18. Brassard DL, Maxwell E, Malkowski M, Nagabhushan TL, Kumar CC, Armstrong L 1999 Integrin αvβ3-mediated activation of apoptosis. Exp Cell Res 251:33-45.
19. Lane NE, Kumer JL, Majumdar S, Khan M, Lotz J, Steven RE, Klein R, Phelps KV 2002 The effects of synthetic conjugated estrogens, A (Cenestin) on trabecular bone structure and strength in the ovariectomized rat model. Osteoporos Int 13:816-823.
20. Lane NE, Yao W, Kinney JH, Modin G, Balooch M, Wronski TJ 2003 Both hPTH (1-34) and bFGF increase trabecular bone mass in osteopenic rats, however they have different effects on trabecular bone architecture. J Bone Miner Res 18:2105-2115.
21. Laib A, Kumer JL, Majumdar S, Lane N 2001 The temporal changes in trabecular architecture in ovariectomized rats assessed by microCT. Osteoporos Int 12:936-941.
22. Hildebrand T, Rüegsegger P 1997 A new method for the model independent assessment of thickness in three-dimensional images. J Microsc 85:67-75.
23. Lorensen WE, Cline HE 1987 Marching cubes: A high-resolution 3D surface construction algorithm. Comput Graph 21:163-169.
24. Hildebrand T, Rüegsegger P 1997 Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Eng 1:15-23.
25. Yao W, Jee WSS, Chen JL, Liu HY, Tam C, Cui L, Zhou H, Frost HM 2000 Making rats rise to bipedal stance added bone to the intact rats and partially prevented bone loss induced by orchidectomy. J Bone Miner Res 15:1158-1168.
26. Parfitt AM, Drezner MK, Glorieux FH, Janis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standardization of nomenclature, symbols and units. Report of the ASBMR Histomorphometry Committee. J Bone Miner Res 2:595-610.
27. Parfitt AM, Matthews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS 1983 Relationships between surface, area, and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 72:1396-1409.
28. Helfrich MH, Nesbitt SA, Lakkakorpi PT, Barnes MJ, Bodary SC, Shankar G, Mason WT, Mendrick DI, Horton MA 1999 Integrins and osteoclast function: Involvement in collagen recognition and bone resorption. Bone 19:317-328.
29. Horton MA, Massey HM, Rosenberg N, Nicholls B, Seligsohn U, Flanagan AM 2003 Upregulation of osteoclast α2β1 integrin compensates for lack of αvβ3 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia. Br J Haemtol 122: 950-957.
30. Cappellen D, Luong-Nguyen NH, Bongiovanni S, Grenet O, Wanke C, Susa M 2002 Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFκB. J Biol Chem 277:21971-21982.
31. Cenci S, Weitzmann N, Roggia C, Namba N, Novack D, Woodring J, Pacifici R 2000 Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α. J Clin Invest 106:1229-1237.
32. Faccio R, Takeshita S, Zallone A, Ross FP, Teitelbaum SL 2003 c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation. J Clin Invest 111:749-758.
33. Takeshita S, Namba N, Zhao JJ, Jiang YB, Genant H, Silva MJ, Brodt MD, Helgason CD, Kalesnikoff J, Rauh M, Humphires RH, Krystal G, Teitelbaum SL, Ross FP 2002 SHIP-deficient mice are severely osteoporotic due to increased numbers of her-resorptive osteoclasts. Nat Med 8:943-949.