Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo

Cancer Biology and Therapy

Volumn 3, Issue 5, 2004, Pages 470-476

  Addeo, Raffaele ^a   Casale, Fiorina ^a   Caraglia, Michele ^a   D'Angelo, Velia ^a   Crisci, Stefania ^a   Abbruzzese, Alberto ^a   Di Tullio, Maria Teresa ^a   Indolfi, Paolo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Acute lymphoblastic leukemia; Cell cycle; Childhood; p15; p16; p21; p27; pRb; pRb phosphorylation; Prednisone

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; GLUCOCORTICOID; PREDNISONE; PROTEIN P110; PROTEIN P15; PROTEIN P16; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; CELL CYCLE PROTEIN; CYCLINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B LYMPHOCYTE; CELL CYCLE; CELL CYCLE G1 PHASE; CHILD; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; HUMAN; LEUKEMIA CELL; LYMPHOBLAST; MALE; PREDICTION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STATISTICAL SIGNIFICANCE; ACUTE LYMPHOCYTIC LEUKEMIA; BLAST CELL CRISIS; DRUG EFFECT; METABOLISM; PHOSPHORYLATION;

BLAST CRISIS; CELL CYCLE PROTEINS; CHILD; CYCLINS; FEMALE; G1 PHASE; GLUCOCORTICOIDS; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; PHOSPHORYLATION; PREDNISONE; RETINOBLASTOMA PROTEIN;

EID: 21644452582     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.5.838     Document Type: Article

References (38)

1. Margolin JF, Steuber CP, Poplack DG. Acute Lymphoblastic Leukemia In: Pizzo PA Poplack DG, eds. Principles and Practice of Pediatric Oncology. 4th ed. Lippincott Williams & Wilkins, 2002.
2. 1 events and regulation of cell proliferation. Science 1989; 246:603-8.
3. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY. D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 1994; 14:2066-77.
4. 1-phase progression. Genes Dev 1999; 13:1501-12.
5. Weimberg RA. The retinoblastoma protein and cell cycle control. Cell 1995; 81:323-31.
6. Byson N. The regulation of E2F by pRB-family proteins. Genes Dev 1998; 12:2245-62.
7. Sherr CJ. The Pezcoller Lecture: Cancer cell cycles revisited. Cancer Res 2000; 60:3689-95.
8. Krug U, Ganser A, Koeffler HP. Tumor suppressor genes in normal and malignant hematopoiesis. Oncogene 2002; 21:3475-95.
9. INK4A immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukaemia. Blood 2002; 99:2620-3.
10. Sauerbrey A, Stammler G, Zintl F, Volm M. Expression and prognostic value of the retinoblastoma tumour suppressor gene (RB-1) in childhood acute lymphoblastic leukaemia. Brit J Haematol 1996; 94:99-104.
11. Omura-Minamisawa M, Diccianni MB, Batova A, Chang RC, Bridgeman LJ, Yu J, et al. Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukaemia. Clinical Cancer Res 2000; 6:1219-28.
12. Hyman CB, Sturgeon P. Prednisone therapy of acute lymphatic leukemia in children. Cancer 1956; 9:965-70.
13. Gaynon PS, Desai AA, Bostrom BC. Early response to therapy and outcome in childhood acute lymphoblastic leukemia: A review. Cancer 1997; 80:1717-26.
14. Dordelmann M, Reiter A, Borkhardt A. Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia. Blood 1999; 94:1209-17.
15. 1 arrest and death of ahuman lymphoid cell line. J Cell Physiol 1979; 98:267-78.
16. Casale F, Addeo R, D'Angelo V, Indolfi P, Poggi V, Morgera C, et al. Determination of the in vivo effects of prednisone on Bcl-2 family protein expression in childhood acute lymphoblastic leukaemia. Int J Oncol 2003; 22:123-8
17. Alnemri ES, Fernandes TF, Haldar S, Croce CM, Litwack G. Involvement of Bcl-2 in glucocorticoid apoptosis of human preB-leukemias. Cancer Res 1992; 52:491-5.
18. Ramalingam A, Hirai A, Thompson EA. Inhibition of fibroblast proliferation and regulation of the cyclin kinase inhibitor p21. Mol Endocrinol 1997; 11:577-86.
19. Corroyer S, Nabeyarat E, Clement A. Involvement of the cell cycle inhibitor CIP1/WAF1 in lung alveolar epithelial cell growth arrest induced by glucocorticoids. Endocrinology 1997; 138:3677:85.
20. Rogatsky L, Trowbridge JM, Garabedian MJ. Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. Mol Cell Biol 1997; 17:3181-93.
21. Singh P, Wee Chan S, Hong W. Retinoblastoma protein is functionally distinct from its homologues in affecting clucocorticoid receptor-mediated transcription and apoptosis. J Biol Chem 2001; 276:13762-70.
22. Paggi MG, Baldi A, Bonetto F, Giordano A. Retinoblastoma protein family in cell cycle and cancer: A review. J Cell Biochem 1996; 62:418-30.
23. Bennet JM, Catovskj D, Daniel MT. The FAB Cooperative Group: The morphological calssification of acute lymphoblastic leukemia: Concordance among observers and clinical correlation. Br J Haematol 1981; 47:553-61.
24. Bene MC, Castoldi G, Knapp W. Proposals for the immunological classification of Acute leukemias. EGIL Leukemia 1996; 9:1783-6.
25. 1-arrested human breast cancer cells. Oncogene 1996; 12:2315-24.
26. Gaynon PS, Lustig RH. The use of glucocorticoids in acute lymphoblastic leukaemia of childhood. Molecular, cellular, and clinical considerations. J Pediatr Hematol Oncol 1995; 17:1-12.
27. Rhee K, Bresnahan W, Hirai A, Hirai M, Thompson A. C-myc and cyclin D3 genes are independent targets for glucocorticoid inhibition of lymphoid cell proliferation Cancer Res 1995; 55:4188-95.
28. 1 cyclin-dependent kinase genes in lymphoid cells. Cell Growth Differ 1995; 6:691-8.
29. Ohnishi H, Kawamura M, Ida K, Sheng XM, Hanada R, Nobori T, et al. Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukaemia. Blood 1995; 86:1269-75.
30. Ogawa S, Hangaishi A, Miyawaki S, Hirosawa S, Miura Y, Takeyama K, et al. Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies. Blood 1995; 86:1548-56.
31. Quesnel B, Preudhomme C, Philippe N, Vanrumbeke M, Dervite I, Lai JL, et al. p16 gene homozygous deletions in acute lymphoblastic leukemia. Blood. 1995; 85:657-63.
32. INK4A sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels. J Biol Chem 2001; 15, 276:10984-9.
33. Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986; 323:643-6.
34. Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY. Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 1987; 235:1394-9.
35. Hollingsworth RE, Hensey CE, Lee WH. Retinoblastoma protein and the cell cycle. Curr Opin Genet Dev 1993; 3:55-62.
36. Sauerbrey A, Stammler G, Zintl F, Volm M. Expression of the retinoblastoma tumor suppressor gene (RB-1) in acute leukemia. Leuk Lymphoma 1998; 28:275-83.
37. Tsai T, Davalath S, Rankin C, Radich JP, Head D, Appelbaum FR, et al. Tumor suppressor gene alteration in adult acute lymphoblastic leukemia (ALL). Analysis of retinoblastoma (Rb) and p53 gene expression in lymphoblasts of patients with de novo, relapsed, or refractory ALL treated in Southwest Oncology Group studies. Leukemia 1996;10:1901-10.
38. Nakayama K, Yamada Y, Koji T, Hayashi T, Tomonaga M, Kamihira S. Expression and phosphorylation status of retinoblastoma protein in adult T-cell leukemia/lymphoma. Leuk Res 2000; 24:299-305.