Models for pancreatic cancer: Giant steps forward, miles to go

Drug Discovery Today: Disease Models

Volumn 2, Issue 1, 2005, Pages 27-33

  Thomas, Ryan ^a   Lowy, Andrew M ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA;

CANCER CELL CULTURE; CANCER MODEL; CANCER MORTALITY; CANCER PREVENTION; CANCER RESEARCH; CANCER SURVIVAL; CARCINOGENESIS; CELL IMMORTALIZATION; COMPUTER MODEL; DNA MODIFICATION; GENE MUTATION; HUMAN; NONHUMAN; PANCREAS CANCER; PANCREAS DUCT; REVIEW; TRANSGENIC MOUSE; UNITED STATES; ZEBRA FISH;

EID: 21644438153     PISSN: 17406757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmod.2005.05.012     Document Type: Review

References (28)

1. R. Brand and C. Mahr Risk factors for pancreatic adenocarcinoma: Are we ready for screening and surveillance? Curr. Gastroenterol. Rep. 7 2005 122-127
2. T.P. Yeo et al. Pancreatic cancer Curr. Probl. Cancer. 26 2002 176-275
3. N. Bardeesy and R.A. DePinho Pancreatic cancer biology and genetics Nat. Rev. Cancer. 2 2002 897-909
4. F.S. Schreiber et al. Successful growth and characterization of mouse pancreatic ductal cells: Functional properties of the Ki-Ras (G12V) oncogene Gastroenterology 127 2004 250-260
5. K.M. Lee et al. Immortalization with telomerase of the Nestin-positive cells of the human pancreas Biochem. Biophys. Res. Commun. 301 2003 1038-1044
6. X. Zhang et al. Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model Clin. Cancer Res. 11 2005 2337-2344
7. P. Ghaneh et al. Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo Gene Ther. 8 2001 199-208
8. W.E. Fogler et al. Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model Cancer Res. 61 2001 7669-7674
9. D.S. Longnecker The azaserine-induced model of pancreatic carcinogenesis in rats In: D.G. Scarpelli et al. ed. Experimental Pancreatic Carcinogenesis 1987 CRC Press 117-130
10. J.A. Rivera et al. A rat model of pancreatic ductal adenocarcinoma: targeting chemical carcinogens Surgery 122 1997 82-90
11. D.G. Scarpelli and M.S. Rao Transplantable ductal adenocarcinoma of the Syrian hamster pancreas Cancer Res. 39 1979 452-458
12. W.L. Cerny et al. K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian Golden hamster Cancer Res. 52 1992 4507-4513
13. C.J. Quaife et al. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice Cell 48 1987 1023-1034
14. J.D. Ceci et al. Transgenic mice carrying a murine amylase 2.2/SV40 T antigen fusion gene develop pancreatic acinar cell and stomach carcinomas Oncogene 6 1991 323-332
15. S.L. Asa et al. Development of colonic and pancreatic endocrine tumours in mice expressing a glucagon-SV40 T antigen transgene Virchows Arch. 427 1996 595-606
16. E.P. Sandgren et al. Pancreatic tumor pathogenesis reflects the causative genetic lesion Proc. Natl. Acad. Sci. USA 88 1991 93-97
17. M. Wagner et al. Malignant transformation of duct-like cells originating from acini in transforming growth factor-α transgenic mice Gastroenterology 115 1998 254-1262
18. M. Wagner et al. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease Genes Dev. 15 2001 286-293
19. Arf-p53 in the suppression of murine pancreatic neoplasia Mol. Cell. Biol. 22 2002 635-643
20. P.J. Grippo et al. Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice Cancer Res. 63 2003 2016-2019
21. F.H. Brembeck et al. The mutant K-ras oncogene causes pancreatic periductal lymphocyte infiltration and gastric mucous neck cell hyperplasia in transgenic mice Cancer Res. 63 2003 2005-2009
22. S.R. Hingorani et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse Cancer Cell 4 2003 437-450
23. Y. Miyamoto et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis Cancer Cell 3 2003 565-576
24. S.P. Thayer et al. Hedgehog is an early and late mediator of pancreatic tumorigenesis Nature 425 2003 851-856
25. A.J. Aguirre et al. Activated K-ras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma Genes Dev. 17 2003 3112-3126
26. B.C. Lewis et al. The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer Genes Dev. 17 2003 3127-3138
27. N.S. Yee and M. Pack Zebrafish as a model for pancreatic cancer research Methods Mol. Med. 103 2004 273-298
28. H.W. Yang et al. Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish Cancer Res. 20 2004 7256-7262