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Volumn 6, Issue 4, 2005, Pages 383-392

The application of RAGE and GECKO in cell-based target discovery screens

Author keywords

Drug targets; Gene expression; Genetics; Knockout; Libraries; Screens

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; BEVACIZUMAB; BINDING PROTEIN; CARBOHYDRATE BINDING PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 6; CD69 ANTIGEN; CHIMERIC PROTEIN; CISPLATIN; COMPLEMENTARY DNA; COMPLEMENTARY RNA; CYTOTOXIC AGENT; DNA TOPOISOMERASE INHIBITOR; ECTODYSPLASIN A2 RECEPTOR; EZETIMIBE; GENE PRODUCT; HYGROMYCIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; ISOPROTEIN; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; PACLITAXEL; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PROTEIN TYROSINE KINASE; PROTEINASE INHIBITOR; RECEPTOR PROTEIN; RIBAVIRIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; SIMVASTATIN; SMALL INTERFERING RNA; TAK1 BINDING PROTEIN 3; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

EID: 21444448876     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/14622416.6.4.383     Document Type: Review
Times cited : (2)

References (38)
  • 1
    • 0037267313 scopus 로고    scopus 로고
    • Knockouts model the 100 best-selling drugs; will they model the next 100?
    • Zambrowicz BP, Sands AT: Knockouts model the 100 best-selling drugs; will they model the next 100? Nature Rev. Drug Discov. 2, 38-51 (2003).
    • (2003) Nature Rev. Drug Discov. , vol.2 , pp. 38-51
    • Zambrowicz, B.P.1    Sands, A.T.2
  • 2
    • 0037460729 scopus 로고    scopus 로고
    • Cystic fibrosis
    • Ratjen F, Doring G: Cystic fibrosis. Lancet 361, 681-689 (2003).
    • (2003) Lancet , vol.361 , pp. 681-689
    • Ratjen, F.1    Doring, G.2
  • 3
    • 0038725634 scopus 로고    scopus 로고
    • Pharmacological strategies for muscular dystrophy
    • Khurana TS, Davies KE: Pharmacological strategies for muscular dystrophy. Nature Rev. Drug Discov. 2, 379-390 (2003).
    • (2003) Nature Rev. Drug Discov. , vol.2 , pp. 379-390
    • Khurana, T.S.1    Davies, K.E.2
  • 5
    • 0036854210 scopus 로고    scopus 로고
    • The design, execution, and interpretation of genetic association studies to decipher complex diseases
    • Romero R, Kuivaniemi H, Tromp G, Olson J: The design, execution, and interpretation of genetic association studies to decipher complex diseases. Am. J. Obstet. Gynecol. 187, 1299-1312 (2002).
    • (2002) Am. J. Obstet. Gynecol. , vol.187 , pp. 1299-1312
    • Romero, R.1    Kuivaniemi, H.2    Tromp, G.3    Olson, J.4
  • 6
    • 0037146578 scopus 로고    scopus 로고
    • Finding genes that underlie complex traits
    • Glazier AM, Nadeau JH, Aitman TJ: Finding genes that underlie complex traits. Science 298, 2345-2349 (2002).
    • (2002) Science , vol.298 , pp. 2345-2349
    • Glazier, A.M.1    Nadeau, J.H.2    Aitman, T.J.3
  • 7
    • 0036790967 scopus 로고    scopus 로고
    • Extracting functional information from microarrays: A challenge for functional genomics
    • Zhang MQ: Extracting functional information from microarrays: a challenge for functional genomics. Proc. Natl Acad. Sci. USA 99, 12509-12511 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12509-12511
    • Zhang, M.Q.1
  • 8
    • 0036884167 scopus 로고    scopus 로고
    • The use and analysis of microarray data
    • Butte A: The use and analysis of microarray data. Nat. Rev. Drug Discov. 1, 951-960 (2002).
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 951-960
    • Butte, A.1
  • 9
    • 0037046160 scopus 로고    scopus 로고
    • Novel antisense and peptide nucleic acid strategies for controlling gene expression
    • Braasch DA, Corey DR: Novel antisense and peptide nucleic acid strategies for controlling gene expression. Biochemistry 41, 4503-4510 (2002).
    • (2002) Biochemistry , vol.41 , pp. 4503-4510
    • Braasch, D.A.1    Corey, D.R.2
  • 10
    • 0347089019 scopus 로고    scopus 로고
    • An approach to genome wide screens of expressed small interfering RNAs in mammalian cells
    • Zheng L, Liu J, Batalov S et al.: An approach to genome wide screens of expressed small interfering RNAs in mammalian cells. Proc. Natl Acad. Sci. USA 101, 135-140 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 135-140
    • Zheng, L.1    Liu, J.2    Batalov, S.3
  • 11
    • 0036212846 scopus 로고    scopus 로고
    • Identification of genes that function in the TNF-α-mediated apoptotic pathway using randomized hybrid ribozyme libraries
    • Kawasaki H, Onuki R, Suyama E, Taira K: Identification of genes that function in the TNF-α-mediated apoptotic pathway using randomized hybrid ribozyme libraries. Nat. Biotechnol. 20, 376-380 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 376-380
    • Kawasaki, H.1    Onuki, R.2    Suyama, E.3    Taira, K.4
  • 12
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • Hannon GJ, Rossi JJ: Unlocking the potential of the human genome with RNA interference. Nature 431, 371-378 (2004).
    • (2004) Nature , vol.431 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 13
    • 1042275604 scopus 로고    scopus 로고
    • Protein expression clone repositories for functional proteomics
    • Pearlberg J, LaBaer J: Protein expression clone repositories for functional proteomics. Curr. Opin. Chem. Biol. 8, 98-102 (2004).
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 98-102
    • Pearlberg, J.1    LaBaer, J.2
  • 14
    • 0035007025 scopus 로고    scopus 로고
    • Creation of genome-wide protein expression libraries using random activation of gene expression
    • Harrington J, Sherf B, Rundlett S et al.: Creation of genome-wide protein expression libraries using random activation of gene expression. Nature Biotechnol. 19, 440-445 (2001).
    • (2001) Nature Biotechnol. , vol.19 , pp. 440-445
    • Harrington, J.1    Sherf, B.2    Rundlett, S.3
  • 15
    • 0347623371 scopus 로고    scopus 로고
    • Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
    • Johnson JM, Castle J, Garrett-Engele P, et al.: Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 302, 2141-2144 (2003).
    • (2003) Science , vol.302 , pp. 2141-2144
    • Johnson, J.M.1    Castle, J.2    Garrett-Engele, P.3
  • 16
    • 0035036534 scopus 로고    scopus 로고
    • Gene structure prediction and alternative splicing analysis using genomically aligned ESTs
    • Kan Z, Rouchka EC, Gish WR, States DJ: Gene structure prediction and alternative splicing analysis using genomically aligned ESTs. Genome Res. 11, 889-900 (2001).
    • (2001) Genome Res. , vol.11 , pp. 889-900
    • Kan, Z.1    Rouchka, E.C.2    Gish, W.R.3    States, D.J.4
  • 17
    • 0037313165 scopus 로고    scopus 로고
    • Correction of disease-associated exon skipping by synthetic exon-specific activators
    • Cartegni L, Krainer A: Correction of disease-associated exon skipping by synthetic exon-specific activators. Nat. Struct. Biol. 10, 120-125 (2003).
    • (2003) Nat. Struct. Biol. , vol.10 , pp. 120-125
    • Cartegni, L.1    Krainer, A.2
  • 18
    • 0037062982 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing and proteome expansion in metazoans
    • Maniatis T, Tasic B: Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 418, 236-243 (2002).
    • (2002) Nature , vol.418 , pp. 236-243
    • Maniatis, T.1    Tasic, B.2
  • 19
    • 10744220155 scopus 로고    scopus 로고
    • Identification of a human NF-κB-activating protein, TAB3
    • Jin G, Klika A, Callahan M, et al. Identification of a human NF-κB-activating protein, TAB3. Proc. Natl. Acad. Sci. USA 17, 2028-2033 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.17 , pp. 2028-2033
    • Jin, G.1    Klika, A.2    Callahan, M.3
  • 20
    • 0034978134 scopus 로고    scopus 로고
    • Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin
    • Moors MA, Li L, Mizel SB: Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin. Infect. Immun. 69, 4424-4429 (2001).
    • (2001) Infect. Immun. , vol.69 , pp. 4424-4429
    • Moors, M.A.1    Li, L.2    Mizel, S.B.3
  • 21
    • 0033761628 scopus 로고    scopus 로고
    • Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors
    • Yan M, Wang LC, Hymowitz SG, et al.: Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 290, 523-527 (2000).
    • (2000) Science , vol.290 , pp. 523-527
    • Yan, M.1    Wang, L.C.2    Hymowitz, S.G.3
  • 22
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-B
    • Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G: Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-B. J. Biol. Chem. 276, 4812-4818 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 4812-4818
    • Ogura, Y.1    Inohara, N.2    Benito, A.3    Chen, F.F.4    Yamaoka, S.5    Nunez, G.6
  • 23
  • 25
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio M, Ni J, Feng P. Dixit VM: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612-1615 (1997).
    • (1997) Science , vol.278 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 26
    • 0041355281 scopus 로고    scopus 로고
    • CARD6 is a modulator of NF-κB activation by Nod1-and Cardiak-mediated pathways
    • Stehlik C, Hayashi H, Pio F, Godzik A, Reed JC: CARD6 is a modulator of NF-κB activation by Nod1-and Cardiak-mediated pathways. J. Biol. Chem. 278, 31941-31949 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 31941-31949
    • Stehlik, C.1    Hayashi, H.2    Pio, F.3    Godzik, A.4    Reed, J.C.5
  • 27
    • 0037329757 scopus 로고    scopus 로고
    • Mutagenesis strategies for identifying novel loci associated with disease phenotypes
    • Brown SD, Hardisty RE: Mutagenesis strategies for identifying novel loci associated with disease phenotypes. Semin. Cell. Dev. Biol. 14, 19-24 (2003).
    • (2003) Semin. Cell. Dev. Biol. , vol.14 , pp. 19-24
    • Brown, S.D.1    Hardisty, R.E.2
  • 29
    • 12844281121 scopus 로고    scopus 로고
    • Analysis of FDA approved anticancer drugs reveals the future of cancer therapy
    • Blagosklonny MV: Analysis of FDA approved anticancer drugs reveals the future of cancer therapy. Cell Cycle 3, 1035-1042 (2004).
    • (2004) Cell Cycle , vol.3 , pp. 1035-1042
    • Blagosklonny, M.V.1
  • 30
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF et al.: Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J. Clin. Oncol. 22, 2184-2191 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 31
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al.: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335-2342 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 33
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran B, Carcelain G, Li TS et al.: Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 277, 112-116 (1997).
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 34
    • 0037299113 scopus 로고    scopus 로고
    • Current therapy for hepatitis C: Pegylaxed interferon and ribavirin
    • McHutchison JG, Fried MW. Current therapy for hepatitis C: pegylaxed interferon and ribavirin. Clin. Liver. Dis. 7, 149-161 (2003).
    • (2003) Clin. Liver. Dis. , vol.7 , pp. 149-161
    • McHutchison, J.G.1    Fried, M.W.2
  • 35
    • 0021751596 scopus 로고
    • Amoxicillin-potassium clavulanate, a β-lactamase-resistant antibiotic combination
    • Stein GE, Gurwith MJ: Amoxicillin-potassium clavulanate, a β-lactamase-resistant antibiotic combination. Clin. Pharm. 3, 591-599 (1984).
    • (1984) Clin. Pharm. , vol.3 , pp. 591-599
    • Stein, G.E.1    Gurwith, M.J.2
  • 36
    • 2942607406 scopus 로고    scopus 로고
    • Efficacy and safety of ezetimibe co-administered with simvastatin compared with atorvastatin in adults with hypercholesterolemia
    • Ballantyne CM, Blazing MA, King TR, Brady WE, Palmisano J: Efficacy and safety of ezetimibe co-administered with simvastatin compared with atorvastatin in adults with hypercholesterolemia. Am. J. Cardiol. 93, 1487-1494 (2004).
    • (2004) Am. J. Cardiol. , vol.93 , pp. 1487-1494
    • Ballantyne, C.M.1    Blazing, M.A.2    King, T.R.3    Brady, W.E.4    Palmisano, J.5
  • 37
    • 6344265083 scopus 로고    scopus 로고
    • Genome-wide lethality screen identifies new PI4, 5P(2) effectors that regulate the actin cytoskeleton
    • Audhya A, Loewith R, Parsons AB et al.: Genome-wide lethality screen identifies new PI4, 5P(2) effectors that regulate the actin cytoskeleton. EMBO J. 29, 3747-3757 (2004).
    • (2004) EMBO J. , vol.29 , pp. 3747-3757
    • Audhya, A.1    Loewith, R.2    Parsons, A.B.3
  • 38
    • 0026600968 scopus 로고
    • A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth
    • Costigan C, Gehrung S, Snyder M: A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Mol. Cell. Biol. 12, 1162-1178 (1992).
    • (1992) Mol. Cell Biol. , vol.12 , pp. 1162-1178
    • Costigan, C.1    Gehrung, S.2    Snyder, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.