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Volumn 7, Issue 3, 2005, Pages 165-169

Trials of gene therapy for pancreatic carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ADENOVIRUS VECTOR; ANGIOGENIC FACTOR; ANTINEOPLASTIC AGENT; CARCINOEMBRYONIC ANTIGEN; CISPLATIN; COMPLEMENTARY RNA; CYCLOPHOSPHAMIDE; CYTOCHROME P450 2B6; CYTOSINE DEAMINASE; CYTOTOXIC AGENT; FLUCYTOSINE; FLUOROURACIL; FOLINIC ACID; GANCICLOVIR; GEMCITABINE; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; IFOSFAMIDE; INTERLEUKIN 12; K RAS PROTEIN; MATRIX METALLOPROTEINASE; MUCIN 1; MUCIN 4; ONCOLYTIC VIRUS; PRODRUG; PROTEIN P16INK4A; PROTEIN P53; SMAD4 PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; THYMIDINE KINASE; TNFERADE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 21444446011     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-005-0028-7     Document Type: Note
Times cited : (3)

References (69)
  • 1
    • 0030878989 scopus 로고    scopus 로고
    • Low mortality following resection for pancreatic and periampulliary tumours in 1026 patients: UK survey of specialist pancreatic units
    • UK pancreatic cancer group
    • Neoptolemos JP, Russell RC, Bramhall S, Theis B: Low mortality following resection for pancreatic and periampulliary tumours in 1026 patients: UK survey of specialist pancreatic units. UK pancreatic cancer group. Br J Surg 1997, 84:1370-1376.
    • (1997) Br. J. Surg. , vol.84 , pp. 1370-1376
    • Neoptolemos, J.P.1    Russell, R.C.2    Bramhall, S.3    Theis, B.4
  • 2
    • 0036807841 scopus 로고    scopus 로고
    • Epidemiology of pancreatic cancer in Northeastern Italy: Incidence, resectability rate, hospital stay, costs and survival (1990-1992)
    • Pasquali C, Sperti C, Filipponi C, Pedrazzoli S: Epidemiology of pancreatic cancer in Northeastern Italy: incidence, resectability rate, hospital stay, costs and survival (1990-1992). Dig Liver Dis 2002, 34:723-731.
    • (2002) Dig. Liver Dis. , vol.34 , pp. 723-731
    • Pasquali, C.1    Sperti, C.2    Filipponi, C.3    Pedrazzoli, S.4
  • 3
    • 0032985541 scopus 로고    scopus 로고
    • Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the national cancer database
    • Sener SF, Fremgen A, Menck HR, Winchester DP: Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the national cancer database. J Am Coll Surg 1999, 189:1-7.
    • (1999) J. Am. Coll. Surg. , vol.189 , pp. 1-7
    • Sener, S.F.1    Fremgen, A.2    Menck, H.R.3    Winchester, D.P.4
  • 4
    • 0036972017 scopus 로고    scopus 로고
    • Resection for pancreatic cancer in the new millennium
    • Andren-Sandberg A, Neoptolemos JP: Resection for pancreatic cancer in the new millennium. Pancreatology 2002, 2:431-439.
    • (2002) Pancreatology , vol.2 , pp. 431-439
    • Andren-Sandberg, A.1    Neoptolemos, J.P.2
  • 5
    • 0027235498 scopus 로고
    • Pancreas cancer resectional outcome in American University Centers in 1988-1990
    • Edge SB, Schmieg RE Jr, Rosenlof LK, Wilhelm MC: Pancreas cancer resectional outcome in American University Centers in 1988-1990. Cancer 1993, 71:3502-3508.
    • (1993) Cancer , vol.71 , pp. 3502-3508
    • Edge, S.B.1    Schmieg Jr., R.E.2    Rosenlof, L.K.3    Wilhelm, M.C.4
  • 6
    • 0029991497 scopus 로고    scopus 로고
    • Long term survival after curative resection for pancreatic ductal adenocarcinoma: Clinical-pathological analysis of 5-year survivors
    • Conlon KC, Klimstra DS, Brennan MF: Long term survival after curative resection for pancreatic ductal adenocarcinoma: Clinical-pathological analysis of 5-year survivors. Ann Surg 1996, 223:613-622.
    • (1996) Ann. Surg. , vol.223 , pp. 613-622
    • Conlon, K.C.1    Klimstra, D.S.2    Brennan, M.F.3
  • 7
    • 0028946871 scopus 로고
    • Prognostic factors for survival after pancreatioduodenectomy for patients with carcinoma of the pancreatic head region
    • Allema JH, Reinders ME, van Gulik TM, et al.: Prognostic factors for survival after pancreatioduodenectomy for patients with carcinoma of the pancreatic head region. Cancer 1995, 75:2069-2076.
    • (1995) Cancer , vol.75 , pp. 2069-2076
    • Allema, J.H.1    Reinders, M.E.2    van Gulik, T.M.3
  • 8
    • 0028888708 scopus 로고
    • Long-term survival after resection for ductal adencarcinoma of the pancreas. Is it really improving?
    • Nitecki SS, Sarr MG, Colby TV, van Heerden JA: Long-term survival after resection for ductal adencarcinoma of the pancreas. Is it really improving? Ann Surg, 1995, 221:59-66.
    • (1995) Ann. Surg. , vol.221 , pp. 59-66
    • Nitecki, S.S.1    Sarr, M.G.2    Colby, T.V.3    van Heerden, J.A.4
  • 9
    • 0030886799 scopus 로고    scopus 로고
    • Long-term survival in pancreatic cancer: Pylorus-preserving versus Whipple pancreaoduodenectomy
    • Mosca F, Giulianotti PC, Balestracci T, et al.: Long-term survival in pancreatic cancer: pylorus-preserving versus Whipple pancreaoduodenectomy. Surgery 1997, 122:553-566.
    • (1997) Surgery , vol.122 , pp. 553-566
    • Mosca, F.1    Giulianotti, P.C.2    Balestracci, T.3
  • 10
    • 0031427541 scopus 로고    scopus 로고
    • Six hundred fifty consecutive pancreaticoduodenectomies in the 1990's: Pathology, complications and outcomes
    • Yeo CJ, Cameron JL, Sohn TA, et al.: Six hundred fifty consecutive pancreaticoduodenectomies in the 1990's: pathology, complications and outcomes. Ann Surg 1997, 226:248-260.
    • (1997) Ann. Surg. , vol.226 , pp. 248-260
    • Yeo, C.J.1    Cameron, J.L.2    Sohn, T.A.3
  • 11
    • 0033510141 scopus 로고    scopus 로고
    • Pancretoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampulliary adenocarcinoma: Comparison of morbidity and mortality and short-term outcome
    • Yeo CJ, Cameron JL, Sohn TA, et al.: Pancretoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampulliary adenocarcinoma: comparison of morbidity and mortality and short-term outcome. Ann Surg 1999, 229:613-622.
    • (1999) Ann. Surg. , vol.229 , pp. 613-622
    • Yeo, C.J.1    Cameron, J.L.2    Sohn, T.A.3
  • 12
    • 0031918491 scopus 로고    scopus 로고
    • DNA content and other factors associated with ten year survival after resection of pancreatic carcinoma
    • Allison DC, Piantadosi S, Hruban RH, et al.: DNA content and other factors associated with ten year survival after resection of pancreatic carcinoma. J Surg Oncol 1998, 67:151-159.
    • (1998) J. Surg. Oncol. , vol.67 , pp. 151-159
    • Allison, D.C.1    Piantadosi, S.2    Hruban, R.H.3
  • 13
    • 0037343989 scopus 로고    scopus 로고
    • Effects of hospital volume on life expectancy after selected cancer operations in older adults: A decisional analysis
    • Finlayson EV, Birkmeyer JD: Effects of hospital volume on life expectancy after selected cancer operations in older adults: a decisional analysis. J Am Coll Surg 2003, 196:410-417.
    • (2003) J. Am. Coll. Surg. , vol.196 , pp. 410-417
    • Finlayson, E.V.1    Birkmeyer, J.D.2
  • 14
    • 13644262627 scopus 로고    scopus 로고
    • Cancer treatment policies and their effect on survival
    • Northern and Yorkshire Cancer Registry and Information Service
    • Northern and Yorkshire Cancer Registry and Information Service: Cancer treatment policies and their effect on survival. Pancreas 2000, 4.3:19.
    • (2000) Pancreas , vol.4 , Issue.3 , pp. 19
  • 15
    • 0036241204 scopus 로고    scopus 로고
    • Complications of pancreatic cancer resection
    • Halloran CM, Ghaneh P, Bosonnet L, et al.: Complications of pancreatic cancer resection. Dig Surg 2002, 19:138-146.
    • (2002) Dig. Surg. , vol.19 , pp. 138-146
    • Halloran, C.M.1    Ghaneh, P.2    Bosonnet, L.3
  • 16
    • 0025325071 scopus 로고
    • Evaluation of the antitumour activity of gemcitabine (2′,2′-diflluoro-2′-deoxycytidine)
    • Hertel LW, Boder GB, Kroin JS, et al.: Evaluation of the antitumour activity of gemcitabine (2′,2′-diflluoro-2′-deoxycytidine). Cancer Res 1990, 50:4417-4422.
    • (1990) Cancer Res. , vol.50 , pp. 4417-4422
    • Hertel, L.W.1    Boder, G.B.2    Kroin, J.S.3
  • 17
    • 0026324313 scopus 로고
    • Action of 2′,2′-difluorodeoxycitadine on DNA synthesis
    • Huang P, Chubb S, Hertel LW, et al.: Action of 2′,2′-difluorodeoxycitadine on DNA synthesis. Cancer Res 1991, 51:6110-6117.
    • (1991) Cancer Res. , vol.51 , pp. 6110-6117
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3
  • 18
    • 0031708742 scopus 로고    scopus 로고
    • Review article: Current treatment and optimal patient management in pancreatic cancer
    • Haycox A, Lombard M, Neoptolemos J, Walley T: Review article: current treatment and optimal patient management in pancreatic cancer. Aliment Pharmacol Ther 1998, 12:949-964.
    • (1998) Aliment. Pharmacol. Ther. , vol.12 , pp. 949-964
    • Haycox, A.1    Lombard, M.2    Neoptolemos, J.3    Walley, T.4
  • 19
    • 0027980010 scopus 로고
    • Preclinical and clinical aspects of biomodulation of 5-fluorouracil
    • Sotos GA, Grogan L, Allegra CJ: Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Cancer Treat Rev 1994, 20:11-49.
    • (1994) Cancer Treat. Rev. , vol.20 , pp. 11-49
    • Sotos, G.A.1    Grogan, L.2    Allegra, C.J.3
  • 20
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreatic cancer: A randomised trial
    • Burris HA III, Moore MJ, Andersen J, et al.: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreatic cancer: a randomised trial. J Clin Oncol 1997, 15:2403-2413.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3
  • 21
    • 0033497862 scopus 로고    scopus 로고
    • Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampulliary region
    • A phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group
    • Klinkenbijl JH, Jeekel J, Sahmoud T, et al.: Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampulliary region. A phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group. Ann Surg 1999, 230:776-784.
    • (1999) Ann. Surg. , vol.230 , pp. 776-784
    • Klinkenbijl, J.H.1    Jeekel, J.2    Sahmoud, T.3
  • 22
    • 0035841631 scopus 로고    scopus 로고
    • Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: A randomised controlled trial
    • Neoptolemos JP, Dunn JA, Stocken DD, et al.: Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial. Lancet 2001, 358:1576-1585.
    • (2001) Lancet , vol.358 , pp. 1576-1585
    • Neoptolemos, J.P.1    Dunn, J.A.2    Stocken, D.D.3
  • 23
    • 0028985078 scopus 로고
    • Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study
    • Bramhall SR, Allum WH, Jones AG, et al.: Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br J Surg 1995, 82:111-115.
    • (1995) Br. J. Surg. , vol.82 , pp. 111-115
    • Bramhall, S.R.1    Allum, W.H.2    Jones, A.G.3
  • 24
    • 0034434535 scopus 로고    scopus 로고
    • Gene therapy for pancreatic cancer: Current and prospective strategies
    • Halloran CM, Ghaneh P, Neoptolemos JP, Costello E: Gene therapy for pancreatic cancer: current and prospective strategies. Surg Oncol 2000, 9:181-191.
    • (2000) Surg. Oncol. , vol.9 , pp. 181-191
    • Halloran, C.M.1    Ghaneh, P.2    Neoptolemos, J.P.3    Costello, E.4
  • 25
    • 0030988302 scopus 로고    scopus 로고
    • p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
    • Moskaluk CA, Hruban RH, Kern SE: p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 1997, 57:2140-2143.
    • (1997) Cancer Res. , vol.57 , pp. 2140-2143
    • Moskaluk, C.A.1    Hruban, R.H.2    Kern, S.E.3
  • 26
    • 0029031872 scopus 로고
    • Abnormalities of the RB1 and DCC tumor suppressor genes: Uncommon in human pancreatic adenocarcinoma
    • Barton CM, McKie AB, Hogg A, et al.: Abnormalities of the RB1 and DCC tumor suppressor genes: uncommon in human pancreatic adenocarcinoma. Mol Carcinog 1995, 13:61-69.
    • (1995) Mol. Carcinog. , vol.13 , pp. 61-69
    • Barton, C.M.1    McKie, A.B.2    Hogg, A.3
  • 27
    • 14444284330 scopus 로고    scopus 로고
    • Tumour suppresser pathways in pancreatic cancer
    • Rozenblum E, Schutte M, Goggins M, et al.: Tumour suppresser pathways in pancreatic cancer. Cancer Res 1997, 57:1731-1734.
    • (1997) Cancer Res. , vol.57 , pp. 1731-1734
    • Rozenblum, E.1    Schutte, M.2    Goggins, M.3
  • 28
    • 0030498918 scopus 로고    scopus 로고
    • Suppression of pancreatic cancer by the dominant negative ras mutant, N116Y
    • Katoh H, Kuzumaki N, Schichiwohe T, et al.: Suppression of pancreatic cancer by the dominant negative ras mutant, N116Y. J Surg Res, 1996. 66:25-130.
    • (1996) J. Surg. Res. , vol.66 , pp. 25-130
    • Katoh, H.1    Kuzumaki, N.2    Schichiwohe, T.3
  • 29
    • 0034114490 scopus 로고    scopus 로고
    • The dominant negative H-ras mutant, N116Y, suppresses growth of metastatic human pancreatic cancer cells in the liver of nude mice
    • Takeuchi M, Shichinohe T, Senmaru N, et al.: The dominant negative H-ras mutant, N116Y, suppresses growth of metastatic human pancreatic cancer cells in the liver of nude mice. Gene Ther 2000, 7:518-526.
    • (2000) Gene Ther. , vol.7 , pp. 518-526
    • Takeuchi, M.1    Shichinohe, T.2    Senmaru, N.3
  • 30
    • 0030749292 scopus 로고    scopus 로고
    • Cytotoxic CD4+ and CD8+ T lymphocytes generated by mutant p21-ras (12 val) peptide vaccination of a patient recognise 12 val dependant nested epitopes present with in the vaccine peptide and kill autologous tumour cells carrying this mutant
    • Gjertsen MK, Bjorheim J, Saeterdal I, et al.: Cytotoxic CD4+ and CD8+ T lymphocytes generated by mutant p21-ras (12 val) peptide vaccination of a patient recognise 12 val dependant nested epitopes present with in the vaccine peptide and kill autologous tumour cells carrying this mutant. Int J Cancer 1997, 72:784-790.
    • (1997) Int. J. Cancer , vol.72 , pp. 784-790
    • Gjertsen, M.K.1    Bjorheim, J.2    Saeterdal, I.3
  • 31
    • 0029825827 scopus 로고    scopus 로고
    • Characterisation of immune response in pancreatic cancer patients after mutant p21-ras peptide vaccination
    • Gjertsen MK, Saeterdal I, Thorsby E, Gaudernack G: Characterisation of immune response in pancreatic cancer patients after mutant p21-ras peptide vaccination. Br J Cancer 1996, 74:1828-1833.
    • (1996) Br. J. Cancer , vol.74 , pp. 1828-1833
    • Gjertsen, M.K.1    Saeterdal, I.2    Thorsby, E.3    Gaudernack, G.4
  • 32
    • 0029124127 scopus 로고
    • Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumour dissemination in the murine peritoneal cavity
    • Aoki K, Yoshida T, Sugimura T, Terada M: Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumour dissemination in the murine peritoneal cavity. Cancer Res 1995, 55:3810-3816.
    • (1995) Cancer Res. , vol.55 , pp. 3810-3816
    • Aoki, K.1    Yoshida, T.2    Sugimura, T.3    Terada, M.4
  • 33
    • 0030710098 scopus 로고    scopus 로고
    • Suppression of Ki-ras p21-ras levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras muations but not those with out Ki-ras mutations
    • Aoki K, Yoshida T, Matsumoto N, et al.: Suppression of Ki-ras p21-ras levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras muations but not those with out Ki-ras mutations. Mol Carcinog 1997, 20:251-258.
    • (1997) Mol. Carcinog. , vol.20 , pp. 251-258
    • Aoki, K.1    Yoshida, T.2    Matsumoto, N.3
  • 34
    • 13644249267 scopus 로고    scopus 로고
    • Interferon-alpha and antisense K-ras RNA combination gene therapy against pancreatic cancer
    • Hatanaka K, Suzuki K, Miura Y, et al.: Interferon-alpha and antisense K-ras RNA combination gene therapy against pancreatic cancer. J Gene Med 2004, 6:1139-1148.
    • (2004) J. Gene Med. , vol.6 , pp. 1139-1148
    • Hatanaka, K.1    Suzuki, K.2    Miura, Y.3
  • 35
    • 0028108985 scopus 로고
    • Database of p53 gene somatic mutations in human tumours and cell lines
    • Hollstein M, Rice K, Greenblatt MS, et al.: Database of p53 gene somatic mutations in human tumours and cell lines. Nucleic Acids Res 1994, 22:3551-3555.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 3551-3555
    • Hollstein, M.1    Rice, K.2    Greenblatt, M.S.3
  • 36
    • 0842265037 scopus 로고    scopus 로고
    • Wild-type p53 gene transfer is not detrimental to normal cells in vivo: Implications for tumor gene therapy
    • Bossi G, Mazzaro G, Porrello A, et al.: Wild-type p53 gene transfer is not detrimental to normal cells in vivo: implications for tumor gene therapy. Oncogene 2004, 23:418-425.
    • (2004) Oncogene , vol.23 , pp. 418-425
    • Bossi, G.1    Mazzaro, G.2    Porrello, A.3
  • 37
    • 0035114253 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo
    • Ghaneh P, Greenhalf W, Humphreys M, et al.: Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo. Gene Ther 2001, 8:199-208.
    • (2001) Gene Ther. , vol.8 , pp. 199-208
    • Ghaneh, P.1    Greenhalf, W.2    Humphreys, M.3
  • 38
    • 0031648811 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer
    • Bouvet M, Bold RJ, Lee J, et al.: Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer. Ann Surg Oncol 1998, 5:681-688.
    • (1998) Ann. Surg. Oncol. , vol.5 , pp. 681-688
    • Bouvet, M.1    Bold, R.J.2    Lee, J.3
  • 39
    • 0034693635 scopus 로고    scopus 로고
    • K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), Cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinioma
    • Kawesha A, Ghaneh P, Andren-Sandberg A, et al.: K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), Cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinioma. Int J Cancer 2000, 89:469-474.
    • (2000) Int. J. Cancer , vol.89 , pp. 469-474
    • Kawesha, A.1    Ghaneh, P.2    Andren-Sandberg, A.3
  • 40
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • Caldas C, Hahn SA, da Costa LT, et al.: Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994, 8:27-32.
    • (1994) Nat. Genet. , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    da Costa, L.T.3
  • 41
    • 16944367477 scopus 로고    scopus 로고
    • Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
    • Schutte M, Hruban RH, Geradts J, et al.: Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 1997, 57:3126-3130.
    • (1997) Cancer Res. , vol.57 , pp. 3126-3130
    • Schutte, M.1    Hruban, R.H.2    Geradts, J.3
  • 42
    • 0033233277 scopus 로고    scopus 로고
    • P16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation
    • Kobayashi S, Shirasawa H, Sashiyama H, et al.: P16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation. Clin Cancer Res 1999, 5:4182-4185.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 4182-4185
    • Kobayashi, S.1    Shirasawa, H.2    Sashiyama, H.3
  • 43
    • 0033190986 scopus 로고    scopus 로고
    • Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells
    • Cascallo M, Mercade E, Capella G, et al.: Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells. Cancer Gene Ther 1999, 6:428-436.
    • (1999) Cancer Gene Ther. , vol.6 , pp. 428-436
    • Cascallo, M.1    Mercade, E.2    Capella, G.3
  • 44
    • 0033522231 scopus 로고    scopus 로고
    • Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumourigenicity
    • Schreiber M, Muller WJ, Singh G, Graham FL: Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumourigenicity. Oncogene 1999, 18:1663-1676.
    • (1999) Oncogene , vol.18 , pp. 1663-1676
    • Schreiber, M.1    Muller, W.J.2    Singh, G.3    Graham, F.L.4
  • 45
    • 13644257039 scopus 로고    scopus 로고
    • 5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16INK4A greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells
    • Halloran CM, Ghaneh P, Shore S, et al.: 5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16INK4A greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells. J Gene Med 2004, 5:514-525.
    • (2004) J. Gene Med. , vol.5 , pp. 514-525
    • Halloran, C.M.1    Ghaneh, P.2    Shore, S.3
  • 46
    • 2342570309 scopus 로고    scopus 로고
    • Phase I trial of intertumoural injection of an adenovirus encoding interlukin-12 for advanced digestive tumours
    • Sangro B, Mazzolini G, Ruiz J, et al.: Phase I trial of intertumoural injection of an adenovirus encoding interlukin-12 for advanced digestive tumours. J Clin Oncol 2004, 8:1389-1397.
    • (2004) J. Clin. Oncol. , vol.8 , pp. 1389-1397
    • Sangro, B.1    Mazzolini, G.2    Ruiz, J.3
  • 47
    • 85039411332 scopus 로고    scopus 로고
    • Clinicaltrials.gov
    • Clinicaltrials.gov http://www.nci.nih.gov./ct/show/NCT00051467
  • 48
    • 0028108469 scopus 로고
    • Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
    • Huber BE, Austin EA, Richards CA, et al.: Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci U S A 1994, 91:8302-8306.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 8302-8306
    • Huber, B.E.1    Austin, E.A.2    Richards, C.A.3
  • 49
    • 0028148134 scopus 로고
    • Directed enzyme pro drug therapy for pancreatic cancer in vivo
    • DiMaio JM, Clary BM, Via DF, et al.: Directed enzyme pro drug therapy for pancreatic cancer in vivo. Surgery 1994, 116:205-113.
    • (1994) Surgery , vol.116 , pp. 113-205
    • DiMaio, J.M.1    Clary, B.M.2    Via, D.F.3
  • 50
    • 0032760453 scopus 로고    scopus 로고
    • AGA technical review on the epidemiology, diagnosis and treatment of pancreatic ductal adenocarcinoma
    • Di Magno EP, Reber HA, Tempero MA: AGA technical review on the epidemiology, diagnosis and treatment of pancreatic ductal adenocarcinoma. Gastoenterology 1998, 117:1464-1484.
    • (1998) Gastoenterology , vol.117 , pp. 1464-1484
    • Di Magno, E.P.1    Reber, H.A.2    Tempero, M.A.3
  • 51
    • 15144346189 scopus 로고    scopus 로고
    • In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer
    • Ohashi M, Kanai F, Tanaka T, et al.: In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer. Jpn J Cancer Res 1998, 89:457-462.
    • (1998) Jpn. J. Cancer Res. , vol.89 , pp. 457-462
    • Ohashi, M.1    Kanai, F.2    Tanaka, T.3
  • 52
    • 0036267486 scopus 로고    scopus 로고
    • Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors
    • Kleeff J, Fukahi K, Lopez ME, et al.: Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors. Cancer Gene Ther 2002, 9:522-532.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 522-532
    • Kleeff, J.1    Fukahi, K.2    Lopez, M.E.3
  • 53
    • 0027496518 scopus 로고
    • In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase
    • Huber BE, Austin EA, Good SS, et al.: In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res 1993, 53:4619-4626.
    • (1993) Cancer Res. , vol.53 , pp. 4619-4626
    • Huber, B.E.1    Austin, E.A.2    Good, S.S.3
  • 54
    • 0031127632 scopus 로고    scopus 로고
    • In vivo adenoviral mediated gene transfer in the treatment of pancreatic cancer
    • Evoy D, Hirschowitz EA, Naama HA, et al.: In vivo adenoviral mediated gene transfer in the treatment of pancreatic cancer. J Surg Res 1997, 69:226-231.
    • (1997) J. Surg. Res. , vol.69 , pp. 226-231
    • Evoy, D.1    Hirschowitz, E.A.2    Naama, H.A.3
  • 55
    • 0036909628 scopus 로고    scopus 로고
    • Cytochrome P450-based cancer gene therapy: Current status
    • Kan O, Kingsman S, Naylor S: Cytochrome P450-based cancer gene therapy: current status. Expert Opin Biol Ther 2002, 2:857-868.
    • (2002) Expert Opin. Biol. Ther. , vol.2 , pp. 857-868
    • Kan, O.1    Kingsman, S.2    Naylor, S.3
  • 56
    • 85039401676 scopus 로고    scopus 로고
    • Oxford Biomedica
    • Oxford Biomedica. http://www.oxfordbiomedica.co.uk/metxia.htm
  • 57
    • 85039403562 scopus 로고    scopus 로고
    • Cancer Research UK
    • Cancer Research UK. http://www.cancerhelp.org.uk/trials/trials/ trial.asp?freetextsearch=&searchtype=select&trials =4994&tri-alno=4449&soage=1&objective=0&cancer= 93&stage=0&phase=0&treatment=0&location=0
  • 58
    • 85039407288 scopus 로고    scopus 로고
    • Division of Surgery and Oncology, University of Liverpool
    • Division of Surgery and Oncology, University of Liverpool. http://www.liv.ac.uk/surgery/Metxia.html
  • 59
    • 0342467852 scopus 로고    scopus 로고
    • Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma
    • Lohr M, Hoffmeyer A, Kroger J, et al.: Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma. Lancet 2001, 357:1591-1592.
    • (2001) Lancet , vol.357 , pp. 1591-1592
    • Lohr, M.1    Hoffmeyer, A.2    Kroger, J.3
  • 60
    • 0036244747 scopus 로고    scopus 로고
    • Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumour: The magic bullets of the 21st century
    • Lohr M, Hummel F, Faulmann G, et al.: Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumour: the magic bullets of the 21st century. Cancer Chemother Pharmacol 2002, 49:S21-S24.
    • (2002) Cancer Chemother. Pharmacol. , vol.49
    • Lohr, M.1    Hummel, F.2    Faulmann, G.3
  • 61
    • 19944396442 scopus 로고    scopus 로고
    • Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells: Low dose ifosfamide and local tumour irradiation
    • Ryschich E, Jesnowski R, Ringel J, et al.: Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells: Low dose ifosfamide and local tumour irradiation. Int J Cancer 2005, 113:649-653.
    • (2005) Int. J. Cancer , vol.113 , pp. 649-653
    • Ryschich, E.1    Jesnowski, R.2    Ringel, J.3
  • 62
    • 0023099280 scopus 로고
    • Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection
    • Barker DD, Berk AJ: Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology 1987, 156:107-121.
    • (1987) Virology , vol.156 , pp. 107-121
    • Barker, D.D.1    Berk, A.J.2
  • 63
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-defecient human tumour cells
    • Bischoff JR, Kirn DH, Williams A, et al.: An adenovirus mutant that replicates selectively in p53-defecient human tumour cells. Science 1996, 274:373-376.
    • (1996) Science , vol.274 , pp. 373-376
    • Bischoff, J.R.1    Kirn, D.H.2    Williams, A.3
  • 64
    • 0031451158 scopus 로고    scopus 로고
    • Viral transactivating proteins
    • Flint J, Shenk T: Viral transactivating proteins. Annu Rev Genet 1997, 3:177-212.
    • (1997) Annu. Rev. Genet. , vol.3 , pp. 177-212
    • Flint, J.1    Shenk, T.2
  • 65
    • 0037033736 scopus 로고    scopus 로고
    • ONYX-015: Mechanisms of action and clinical potential of a replication-selective adenovirus
    • Ries S, Korn WM: ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus. Br J Cancer 2002, 86:5-11.
    • (2002) Br. J. Cancer , vol.86 , pp. 5-11
    • Ries, S.1    Korn, W.M.2
  • 66
    • 0037314610 scopus 로고    scopus 로고
    • A phase I/II trial of intratumoural endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma
    • Hecht JR, Bedford R, Abbruzzese JL, et al.: A phase I/II trial of intratumoural endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin Can Res 2003, 9:555-561.
    • (2003) Clin. Can. Res. , vol.9 , pp. 555-561
    • Hecht, J.R.1    Bedford, R.2    Abbruzzese, J.L.3
  • 67
    • 0035076823 scopus 로고    scopus 로고
    • Safety and feasibility of injection with an E1B-55kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A phase I trial
    • Mulvihill S, Warren R, Venook A, et al.: Safety and feasibility of injection with an E1B-55kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial. Gene Ther 2001, 8:308-315.
    • (2001) Gene Ther. , vol.8 , pp. 308-315
    • Mulvihill, S.1    Warren, R.2    Venook, A.3
  • 68
    • 0035915763 scopus 로고    scopus 로고
    • Systemic administration of a matrix-targetted retroviral vector is efficacious for cancer gene therapy in mice
    • Gordon EM, Chen ZH, Liu L, et al.: Systemic administration of a matrix-targetted retroviral vector is efficacious for cancer gene therapy in mice. Hum Gene Ther 2001, 12:193-204.
    • (2001) Hum. Gene Ther. , vol.12 , pp. 193-204
    • Gordon, E.M.1    Chen, Z.H.2    Liu, L.3
  • 69
    • 3843123314 scopus 로고    scopus 로고
    • First clinical experience using a 'pathotropic' injectable retroviral vector (Rexin-G) as intervention for stage IV pancreatic cancer
    • Gordon EM, Cornelio GH, Lorenzo CC III, et al.: First clinical experience using a 'pathotropic' injectable retroviral vector (Rexin-G) as intervention for stage IV pancreatic cancer. Int J Oncol 2004, 24:177-185.
    • (2004) Int. J. Oncol. , vol.24 , pp. 177-185
    • Gordon, E.M.1    Cornelio, G.H.2    Lorenzo III, C.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.