Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation

International Journal of Cancer

Volumn 72, Issue 5, 1997, Pages 784-790

  Gjertsen, Marianne K ^a,b   Bjørheim, Jens ^a   Saeterdal, Ingvil ^a   Myklebust, June ^a   Gaudernack, Gustav ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; GLYCINE; MUTANT PROTEIN; PROTEIN P21; RAS PROTEIN; RECOMBINANT VACCINE; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENE MUTATION; HELPER CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; ONCOGENE RAS; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ADENOCARCINOMA; CD4-POSITIVE T-LYMPHOCYTES; EPITOPES; HUMANS; MIDDLE AGED; MUTATION; PANCREATIC NEOPLASMS; PILOT PROJECTS; PROTO-ONCOGENE PROTEINS P21(RAS); T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED; VACCINATION;

EID: 0030749292     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970904)72:5<784::AID-IJC14>3.0.CO;2-9     Document Type: Article

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