Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia - An array study on case-specific human preeclamptic placental tissue

Acta Obstetricia et Gynecologica Scandinavica

Volumn 84, Issue 7, 2005, Pages 679-689

  Heikkilä, Annaleena ^a   Tuomisto, Tiina ^a   Häkkinen, Sanna Kaisa ^a   Keski Nisula, Leea ^a   Heinonen, Seppo ^a   Ylä Herttuala, Seppo ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Array; Gene; Human; Placenta; Preeclampsia

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; COMPLEMENTARY DNA; CYTOKINE; FREE RADICAL; HYPOXIA INDUCIBLE FACTOR 1; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PLACENTA PROTEIN 5; THROMBOPLASTIN; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; APOPTOSIS; ARTICLE; CASE REPORT; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOXIA; INFLAMMATION; OXIDATIVE STRESS; PLACENTA; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ADULT; CESAREAN SECTION; FEMALE; GENE EXPRESSION PROFILING; GENES, REGULATOR; GENES, TUMOR SUPPRESSOR; GESTATIONAL AGE; HUMANS; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; UP-REGULATION;

EID: 21444444736     PISSN: 00016349     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0001-6349.2005.00814.x     Document Type: Article

References (57)

1. Arngrimsson R, Sigurard TS, Frigge ML, Bjarnad TR, Jonsson T, Stefansson H et al. A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum Mol Genet 1999; 8: 1799-805.
2. Harrison GA, Humphrey KE, Jones N, Badenhop R, Guo G, Elakin G et al. A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. Am J Hum Genet 1997; 60: 1158-67.
3. Guo G, Lade JA, Wilton AN, Moses EK, Grehan M, Fu Y et al. Genetic susceptibility to pre-eclampsia and chromosome 7q36. Hum Genet 1999; 105: 641-7.
4. Moses EK, Lade JA, Guo G, Wilton AN, Grehan M, Freed K et al. A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. Am J Hum Genet 2000; 67: 1581-5.
5. Reimer T, Koczan D, Gerber B, Richter D, Thiesen HJ, Friese K. Microarray analysis of differentially expressed genes in placental tissue of pre-eclampsia: up-regulation of obesity-related genes. Mol Hum Reprod 2002; 8: 674-80.
6. Pang ZJ, Xing FQ. DNA microarrays detect the expression of apoptosis-related genes in preeclamptic placentas. Acta Obstet Gynecol Scand 2004; 32: 25-30.
7. Pang ZJ, Xing FQ. Comparative profiling of metabolism-related gene expression in preeclamptic and normal pregnancies. Arch Gynecol Obstet 2004; 269: 91-5.
8. National High Blood Pressure Education Program. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183: S1-S22.
9. Hiltunen M, Tuomisto T, Niemi M, Brasen J, Rissanen T, Toronen P et al. Changes in gene expression in atherosclerotic plaques analyzed using DNA array. Atherosclerosis 2002; 165: 23.
10. Claverie JM. Computational methods for the identification of differential and coordinated gene expression. Hum Mol Genet 1999; 8: 1821-32.
11. Lau KM, Mok SC, Ho SM. Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Proc Natl Acad Sci USA 1999; 96: 5722-7.
12. Chakraborty C, Gleeson LM, McKinnon T, Lala PK. Regulation of human trophoblast migration and invasiveness. Can J Physiol Pharmacol 2002; 80: 116-24.
13. Mellembakken JR, Solum NO, Ueland T, Videm V, Aukrust P. Increased concentrations of soluble CD40 ligand, RANTES and GRO-alpha in preeclampsia - possible role of platelet activation. Thromb Haemost 2001; 86: 1272-6.
14. Evans J, Reuben A, Craft J. PBC 95k, a 95-kilodalton nuclear autoantigen in primary biliary cirrhosis. Arthritis Rheum 1991; 34: 731-6.
15. Ascoli CA, Maul GG. Identification of a novel nuclear domain. J Cell Biol 1991; 112: 785-95.
16. Salafia C, Pijnenborg R. Disorders of the Decidua and Maternal Vasculature. In: Lewis SH, Perrin E, (eds). Pathology of the Placenta, Philadelphia; Churchill Livingstone, 1999, 185-212.
17. Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D et al. Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1. Cancer Res 2002; 62: 397-402.
18. Brower CS, Shilatifard A, Mather T, Kamura T, Takagi Y, Haque D et al. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. J Biol Chem 1999; 274: 13629-36.
19. Darmochwal-Kolarz D, Leszczynska-Gorzelak B, Rolinski J, Oleszczuk J. T helper 1- and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 1999; 86: 165-70.
20. Rein DT, Schondorf T, Gohring UJ, Kurbacher CM, Pinto I, Breidenbach M et al. Cytokine expression in peripheral blood lymphocytes indicates a switch to T (HELPER) cells in patients with preeclampsia. J Reprod Immunol 2002; 54: 133-42.
21. Pang ZJ, Xing FQ. Comparative study on the expression of cytokine-receptor genes in normal and preeclamptic human placentas using DNA microarrays. J Perinat Med 2003; 31: 153-62.
22. Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996; 271: 32253-9.
23. Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K et al. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 1999; 18: 1905-14.
24. Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA et al. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996; 93: 12969-73.
25. Leung DN, Smith SC, To KF, Sahota DS, Baker PN. Increased placental apoptosis in pregnancies complicated by preeclampsia. Am J Obstet Gynecol 2001; 184: 1249-50.
26. Hubel CA, Roberts JM, Taylor RN, Musci TJ, Rogers GM, McLaughlin MK. Lipid peroxidation in pregnancy: new perspectives on preeclampsia. Am J Obstet Gynecol 1989; 161: 1025-34.
27. Johnson RD, Polakoski KL, Huang X, Sadovsky Y, Nelson DM. The release of 15-hydroxyeicosatetraenoic acid by human placental trophoblast is increased in preeclampsia. Am J Obstet Gynecol 1998; 178: 54-8.
28. Parthasarathy S, Wieland E, Steinberg D. A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proc Natl Acad Sci USA 1989; 86: 1046-50.
29. Yla-Herttuala S, Rosenfeld ME, Parthasarathy S, Glass CK, Sigal E, Witztum JL et al. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc Natl Acad Sci USA 1990; 87: 6959-63.
30. Clark P, Boswell F, Greer IA. The neutrophil and preeclampsia. Semin Reprod Endocrinol 1998; 16: 57-64.
31. Lee JN, Salem HT, Huang S, Ouyang PC, Seppala M, Chard T. Placental protein 5 (PP5) in severe pre-eclampsia and eclampsia. Int J Gynaecol Obstet 1981; 19: 65-7.
32. Ross TS, Tait JF, Majerus PW. Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. Science 1990; 248: 605-7.
33. Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J et al. Alterations of the PPP2R1B gene in human lung and colon cancer. Science 1998; 282: 284-7.
34. Zhao J, Zhou Q, Wiedmer T, Sims PJ. Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surface. J Biol Chem 1998; 273: 6603-6.
35. Baldi A, Luca AD, Morini M, Battista T, Felsani A, Baldi F et al. The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells. Oncogene 2002; 21: 6684-8.
36. Chakraborty C, Gleeson LM, McKinnon T, Lala PK. Regulation of human trophoblast migration and invasiveness. Can J Physiol Pharmacol 2002; 80: 116-24.
37. DiSepio D, Ghosn C, Eckert RL, Deucher A, Robinson N, Duvic M et al. Identification and characterization of a retinoid-induced class II tumour suppressor/growth regulatory gene. Proc Natl Acad Sci USA 1998; 95: 14811-5.
38. Hino S, Kawamata H, Omotehara F, Uchida D, Begum NM, Yoshida H et al. Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells. Oncol Report 2002; 9: 371-4.
39. Uchida D, Kawamata H, Omotehara F, Miwa Y, Hino S, Begum NM et al. Over-expression of TSC-22 (TGF-beta stimulated clone-22) markedly enhances 5-fluorouracil-induced apoptosis in a human salivary gland cancer cell line. Lab invest 2000; 80: 955-63.
40. Shaarawy M, El Meleigy M, Rasheed K. Maternal serum transforming growth factor beta-2 in preeclampsia and eclampsia, a potential biomarker for the assessment of disease severity and fetal outcome. J Soc Gynecol Investig 2001; 8: 27-31.
41. Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. J Biol Chem 1998; 273: 25929-36.
42. Gotz R, Karch C, Digby MR, Troppmair J, Rapp UR, Sendtner M. The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells. Hum Mol Genet 2000; 9: 2479-89.
43. Bloch DB, de la Monte SM, Guigaouri P, Filippov A, Bloch KD. Identification and characterization of a leukocyte-specific component of the nuclear body. J Biol Chem 1996; 271: 29198-204.
44. Labarrere CA, Faulk WP. Intercellular adhesion molecule-1 (ICAM-1) and HLA-DR antigens are expressed on endovascular cytotrophoblasts in abnormal pregnancies. Am J Reprod Immunol 1995; 33: 47-53.
45. Austgulen R, Lien E, Vince G, Redman CW. Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia. Eur J Obstet Gynecol Reprod Biol 1997; 71: 53-8.
46. Cybulsky MI, Fries JW, Williams AJ, Sultan P, Eddy R, Byers M et al. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc Natl Acad Sci USA 1991; 88: 7859-63.
47. Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001; 107: 1255-62.
48. Dansky HM, Barlow CB, Lominska C, Sikes JL, Kao C, Weinsaft J et al. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol 2001; 21: 1662-7.
49. Mitchell TC, Hildeman D, Kedl RM, Teague TK, Schaefer BC, White J et al. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat Immun 2001; 2: 397-402.
50. Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RMJ et al. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci USA 1990; 87: 7512-6.
51. Yoneyama Y, Sawa R, Suzuki S, Miura A, Kobayashi H, Doi D et al. Relation between adenosine deaminase activities and cytokine-producing T cells in women with preeclampsia. Clin Biochem 2002; 35: 303-6.
52. Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem 2002; 277: 40112-7.
53. Crawley JT, Goulding DA, Ferreira V, Severs NJ, Lupu F. Expression and localization of tissue factor pathway inhibitor-2 in normal and atherosclerotic human vessels. Arterioscler Thromb Vasc Biol 2002; 22: 218-24.
54. Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL et al. Transcriptional response to hypoxia in human tumours. J Natl Cancer Inst 2001; 93: 1337-43.
55. Zhang K, Lindsberg PJ, Tatlisumak T, Kaste M, Olsen HS, Andersson LC. Stanniocalcin: a molecular guard of neurons during cerebral ischemia. Proc Natl Acad Sci USA 2000; 97: 3637-42.
56. Zusterzeel PL, Peters WH, De Bruyn MA, Knapen MF, Merkus HM, Steegers EA. Glutathione S-transferase isoenzymes in decidua and placenta of preeclamptic pregnancies. Obstet Gynecol 1999; 94: 1033-8.
57. Yamaguchi Y, Matsumura F, Wang FS, Akizuki E, Liang J, Matsuda T et al. Neutrophil elastase enhances intercellular adhesion molecule-1 expression. Transplantation 1998; 65: 1622-8.