Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the α2-receptor-mediated hypotension in conscious SHRs

Journal of Cardiovascular Pharmacology

Volumn 46, Issue 1, 2005, Pages 52-62

  Li, Guichu ^a   Wang, Xu ^a   Abdel Rahman, Abdel A ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

methylnorepinephrine; c Fos; Clonidine; Electrochemistry; NE; Nucleus tractus solitarius; Rilmenidine; Rostral ventrolateral medulla; SHR

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; CORBADRINE; EFAROXAN; IMIDAZOLINE I1 RECEPTOR; NORADRENALIN; RILMENIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; BRAIN REGION; BRAIN STEM; CONTROLLED STUDY; DRUG EFFECT; EVOKED BRAIN STEM RESPONSE; GENE EXPRESSION; HEART RATE; HYPERTENSION; HYPOTENSION; MALE; MEDULLA OBLONGATA; MICROINJECTION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; ROSTRAL VENTROLATERAL MEDULLA; SIGNAL TRANSDUCTION; SOLITARY TRACT NUCLEUS; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC TONE;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; AREA POSTREMA; BENZAZEPINES; BENZOFURANS; BLOOD PRESSURE; CLONIDINE; CONSCIOUSNESS; HEART RATE; HYPOTENSION; IMIDAZOLES; INTERLEUKIN-1; MALE; MOTOR ACTIVITY; NEURONS; NORDEFRIN; NOREPINEPHRINE; OXAZOLES; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC, ALPHA-2; SOLITARY NUCLEUS;

EID: 21444442542     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000162773.54915.52     Document Type: Article

References (52)

1. 1 receptor and the pharmacology of imidazolines. Cardiovasc Drugs Ther. 1994;8(Suppl 1): 21-26.
2. Kobinger. Central alpha-adrenergic systems as targets for hypotensive drugs. Rev Physiol Biochem Pharmacol. 1978;81:39-100.
3. 1 imidazoline receptors in cardiovascular regulation: the place of rilmenidine. Am J Hypertens. 2000;13:89S-98S.
4. Bousquet P, Feldman J. Drugs acting on imidazoline receptors: a review of their pharmacology, their use in blood pressure control and their potential interest in cardioprotection. Drugs. 1999;58:799-812.
5. Reis DJ, Piletz JE. The imidazoline receptor in control of blood pressure by clonidine and allied drugs. Am J Physiol. 1997;273:R1569-R1571.
6. Szabo B. Imidazoline antihypertensive drugs: a critical review on their mechanism of action. Pharmacol Ther. 2002;93:1-35.
7. Yamazato M, Sakima A, Nakazato J, et al. Hypotensive and sedative effects of clonidine injected into the rostral ventrolateral medulla of conscious rats. Am J Physiol Regul Integr Comp Physiol. 2001;281: R1868-R1876.
8. Mao L, Abdel-Rahman AA. Ethanol counteraction of clonidine-evoked inhibition of norepinephrine release in rostral ventrolateral medulla of rats. Alcohol Clin Exp Res. 1998;22:1285-1291.
9. Ross CA, Ruggiero DA, Park DH, et al. Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressin. J Neurosci. 1984;4:474-494.
10. Lawrence AJ, Jarrott B. Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius. Prog Neurobiol. 1996;48:21-53.
11. Allen AM, Guyenet PG. Alpha 2-adrenoceptor-mediated inhibition of bulbospinal barosensitive cells of rat rostral medulla. Am J Physiol. 1993; 265:R1065-R1075.
12. Mermet C, Quintin L. Effect of clonidine on catechol metabolism in the rostral ventrolateral medulla: an in vivo electrochemical study. Eur J Pharmacol. 1991;204:105-107.
13. Tibirica E, Feldman J, Mermet C, et al. Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors. Eur J Pharmacol. 1991;209: 213-221.
14. Bruandet N, Rentero N, Debeer L, et al. Catecholamine activation in the vasomotor center on emergence from anesthesia: the effects of alpha2 agonists. Anesth Analg. 1998;86:240-245.
15. 1-receptor activation in spontaneously hypertensive rats. Alcohol Clin Exp Res. 2003;27:1471-1480.
16. el-Mas MM, Abdel-Rahman AA. Contrasting effects of urethane, ketamine, and thiopental anesthesia on ethanol-clonidine hemodynamic interaction. Alcohol Clin Exp Res. 1997;21:19-27.
17. 2. Am J Physiol. 1997;273:R947-R955.
18. Bhaskaran D, Freed CR. Catechol and indole metabolism in rostral ventrolateral medulla change synchronously with changing blood pressure. J Pharmacol Exp Ther. 1989;249:660-666.
19. Tibirica E, Mermet C, Feldman J, et al. Correlation between the inhibitory effect on catecholaminergic ventrolateral medullary neurons and the hypotension evoked by clonidine: a voltammetric approach. J Pharmacol Exp Ther. 1989;250:642-647.
20. Zhang J, Abdel-Rahman AA. The hypotensive action of rilmenidine is dependent on functional N-methyl-d-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats. J Pharmacol Exp Ther. 2002;303:204-210.
21. 1-Noradrenergic neurons tonically inhibit sympathoexcitatory neurons of C1 area in rat brainstem. Brain Res. 1986;377:127-146.
22. Ernsberger P, Giuliano R, Willette RN, et al. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J Pharmacol Exp Ther. 1990;253:408-418.
23. Dampney RA, Polson JW, Potts PD, et al. Functional organization of brain pathways subserving the baroreceptor reflex: studies in conscious animals using immediate early gene expression. Cell Mol Neurobiol. 2003;23: 597-616.
24. Dragunow M, Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods. 1989;29:261-265.
25. Chen CY, Munch PA, Quail AW, et al. Postexercise hypotension in conscious SHR is attenuated by blockade of substance P receptors in NTS. Am J Physiol Heart Circ Physiol. 2002;283:H1856-H1862.
26. Bhaskaran D, Freed CR. Changes in arterial blood pressure lead to baroreceptor-mediated changes in norepinephrine and 5-hydroxyindole-acetic acid in rat nucleus tractus solitarius. J Pharmacol Exp Ther. 1988; 245:356-363.
27. Gerhardt G. Neuromethods. New York: Humana Press, Inc, 1995.
28. El-Mas MM, Abdel-Rahman AA. Role of NMDA and non-NMDA receptors in the nucleus tractus solitarius in the depressant effect of ethanol on baroreflexes. J Pharmacol Exp Ther. 1993;266:602-610.
29. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, ed 4. San Diego: Academic Press, 1998.
30. Wang X, Abdel-Rahman AA. Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts. Am J Physiol Heart Circ Physiol. 2002;282:H2309-H2315.
31. 1-imidazoline receptors in the rostral ventrolateral medulla. J Cardiovasc Pharmacol. 1994;24 (Suppl 1):S1-S8.
32. Renner KJ, Pazos L, Adams RN. In vivo voltammetric evidence for the detection of norepinephrine release in the thalamus of freely moving rats. Brain Res. 1992;577:49-56.
33. Gomez RE, Ernsberger P, Feinland G, et al. Rilmenidine lowers arterial pressure via imidazole receptors in brainstem Cl area. Eur J Pharmacol. 1991;195:181-191.
34. Kawasaki H, Takasaki K. Central alpha-2 adrenoceptor-mediated hypertensive response to clonidine in conscious, normotensive rats. J Pharmacol Exp Ther. 1986;236:810-818.
35. 3H]clonidine. Eur J Pharmacol. 1994;266: 25-33.
36. Bricca G, Dontenwill M, Molines A, et al. The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem. Eur J Pharmacol. 1989;162:1-9.
37. Szabo B, Fritz T, Wedzony K. Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex. Br J Pharmacol. 2001;134:295-304.
38. Nicholas AP, Pieribone V, Hokfelt T. Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurol. 1993;328:575-594.
39. 3H]-clonidine to identify imidazoline receptors in the rabbit brainstem. Br J Pharmacol. 1993;110:1537-1543.
40. Mayorov DN, Burke SL, Head GA. Relative importance of rostral ventrolateral medulla in sympathoinhibitory action of rilmenidine in conscious and anesthetized rabbits. J Cardiovasc Pharmacol. 2001;37:252-261.
41. Mayorov DN, Head GA. Influence of rostral ventrolateral medulla on renal sympathetic baroreflex in conscious rabbits. Am J Physiol Regul Integr Comp Physiol. 2001;280:R577-R587.
42. 3H]rilmenidine in membranes from rat cerebral cortex. Eur J Pharmacol. 1992;218:101-108.
43. Head GA, Burke SL. Relative importance of medullary brain nuclei for the sympatho-inhibitory actions of rilmenidine in the anaesthetized rabbit. J Hypertens. 1998;16:503-517.
44. Zandberg P, De Jong W, De Wied D. Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata. Eur J Pharmacol. 1979;55:43-56.
45. Stornetta RL, Sevigny CP, Guyenet PG. Vesicular glutamate transporter DNPI/VGLUT2 mRNA is present in C1 and several other groups of brainstem catecholaminergic neurons. J Comp Neurol. 2002;444:191-206.
46. Stornetta RL, Sevigny CP, Schreihofer AM, et al. Vesicular glutamate transporter DNPI/VGLUT2 is expressed by both C1 adrenergic and nonaminergic presympathetic vasomotor neurons of the rat medulla. J Comp Neurol. 2002;444:207-220.
47. Schreihofer AM, Guyenet PG. Role of presympathetic C1 neurons in the sympatholytic and hypotensive effects of clonidine in rats. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1753-R1762.
48. Viltart O, Sequeira H. Induction of c-Fos-like protein in bulbar catecholaminergic neurones by electrical stimulation of the sensorimotor cortex in the rat. Neurosci Lett. 1999;260:65-68.
49. Minson J, Arnolda L, Llewellyn-Smith I, et al. Altered c-fos in rostral medulla and spinal cord of spontaneously hypertensive rats. Hypertension. 1996;27:433-441.
50. Minson JB, Arnolda LF, Llewellyn-Smith IJ, et al. Immediate early genes in blood pressure regulation. Clin Exp Hypertens. 1996;18:279-290.
51. 1 imidazoline receptor selective ligand with hypotensive activity. J Med Chem. 2001;44:1588-1593.
52. Bruban V, Estato V, Schann S, et al. Evidence for synergy between alpha(2)-adrenergic and nonadrenergic mechanisms in central blood pressure regulation. Circulation. 2002;105:1116-1121.