Role of presympathetic C1 neurons in the sympatholytic and hypotensive effects of clonidine in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 279, Issue 5 48-5, 2000, Pages

  Schreihofer, Ann M ^a   Guyenet, Patrice G ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Anti dopamine hydroxylase saporin; Phenylethanolamine N methyl transferase; Rostral ventrolateral medulla; Splanchnic nerve activity; Tyrosine hydroxylase

Indexed keywords

CHLORALOSE; CLONIDINE; SAPORIN; TYROSINE 3 MONOOXYGENASE;

ADRENERGIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG INHIBITION; HYPOTENSION; IMMUNOCOMPETENT CELL; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE CELL;

EID: 0033667878     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.2000.279.5.r1753     Document Type: Article

References (38)

1. 2-adrenergic receptors in gigantocellular reticular formation
2. Monosynaptic projections from the medullary gigantocellular reticular formation to sympathetic preganglionic neurons in the thoracic spinal cord
3. 2-Adrenoceptor-mediated inhibition of bulbospinal barosensitive cells of rat rostral ventrolateral medulla
4. Susceptibility of spontaneous sympathetic outflow and sympathetic reflexes to depression by clonidine
5. Importance of spinal noradrenergic pathways in cardiovascular reflexes and central actions of clonidine and alpha-methyldopa in the rabbit
6. Antagonist precipitated clonidine withdrawal in rat: Effects on locus coeruleus neurons, sympathetic nerves, and cardiovascular parameters
7. Alpha-2 adrenergic receptors rather than 'imidazoline' binding sites mediate the sympatholytic effect of clonidine in the rostral ventrolateral medulla: A new look at the evidence
8. α(2A)-Adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating the spinal cord
9. Electrophysiological characterization of putative C1 adrenergic neurons in the rat
10. Central alpha-adrenoceptors involved in cardiovascular regulation
11. 2-Adrenoceptor-mediated presynaptic inhibition in bulbospinal neurons of rostral ventrolateral medulla
12. Sympatholytic effect of tricyclic antidepressants: Site and mechanism of action in anesthetized rats
13. Inhibition of the activity of sympathetic preganglionic neurones activated by visceral afferents, by alpha-methylnoradrenaline and endogenous catecholamines
14. C1 neurons of neonatal rats: Intrinsic beating properties and alpha 2-adrenergic receptors
15. Barosensitive neurons in the rostral ventrolateral medulla of the rat in vivo: Morphological properties and relationship to C1 adrenergic neurons
16. Lesions of the C1 catecholaminergic neurons of the ventrolateral medulla in rats using anti-DβH-saporin
17. Cardiac effects of injections of epinephrine into the spinal intermediolateral cell column
18. Alpha2A-adrenergic receptors are primarily presynaptic heteroreceptors in the C1 area of the rat rostral ventrolateral medulla
19. Presynaptic inhibition by noradrenaline of the EPSC evoked in neonatal rat sympathetic preganglionic neurons
20. Adrenergic modulation of a spinal sympathetic reflex in the rat
21. Reticulospinal vasomotor neurons of the rat rostral ventrolateral medulla: Relationship to sympathetic nerve activity and the C1 adrenergic cell group
22. A novel single-cell staining procedure performed in vivo under electrophysiological control: Morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or neurobiotin
23. Ventrolateral medullary pressor area: Site of hypotensive action of clonidine
24. Neurons and receptors in the rostroventrolateral medulla mediating the antihypertensive actions of drugs acting at imidazoline receptors
25. The C1 area of the rostral ventrolateral medulla oblongata. A critical brainstem region for control of resting and reflex integration of arterial pressure
26. Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarius of the rat
27. Identification of C1 presympathetic neurons in the rat rostral ventrolateral medulla by juxtacellular labeling in vivo
28. Sympathetic reflexes in rats after depletion of bulbospinal catecholaminergic neurons
29. 2-adrenoreceptors in caudal ventrolateral medulla to cardiovascular regulation in rat
30. Location and electrophysiological characterization of rostral medullary adrenergic neurons that contain neuropeptide Y mRNA in rat medulla
31. Pharmacology of reticulospinal vasomotor neurons in cardiovascular regulation
32. Effect of clonidine and γ-aminobutyric acid on the discharges of medullo-spinal sympathoexcitatory neurons in rat
33. Distribution of α(2a)-adrenergic receptor-like immunoreactivity in the rat central nervous system
34. Evidence for clonidine presynaptically modulating amino acid release in rostral ventrolateral medulla: Role in hypertension
35. Properties of C1 and other ventrolateral medullary neurones with hypothalamic projections in the rat
36. Central noradrenergic lesioning using anti-DBH-saporin: Anatomical findings
37. Slow IPSP and the noradrenaline-induced inhibition of the cat sympathetic preganglionic neuron in vitro