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Volumn 172, Issue 9, 2004, Pages 5338-5345

In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CYCLOPHOSPHAMIDE; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; VACCINE;

EID: 2142828660     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.9.5338     Document Type: Article
Times cited : (29)

References (56)
  • 1
    • 0042470540 scopus 로고    scopus 로고
    • Does the immune system see tumors as foreign or self?
    • Pardoll, D. 2003. Does the immune system see tumors as foreign or self? Annu. Rev. Immunol. 21:807.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 807
    • Pardoll, D.1
  • 3
    • 0029906983 scopus 로고    scopus 로고
    • + T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma
    • + T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma. Eur. J. Immunol. 26:2671.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2671
    • Bogen, B.1
  • 6
    • 0027190467 scopus 로고
    • An evaluation of the potential to use tumor-associated antigens as targets for antitumor T cell therapy using transgenic mice expressing a retroviral tumor antigen in normal lymphoid tissues
    • Hu, J., W. Kindsvogel, S. Busby, M. C. Bailey, Y. Shi, and P. D. Greenberg. 1993. An evaluation of the potential to use tumor-associated antigens as targets for antitumor T cell therapy using transgenic mice expressing a retroviral tumor antigen in normal lymphoid tissues. J. Exp. Med. 177:1681.
    • (1993) J. Exp. Med. , vol.177 , pp. 1681
    • Hu, J.1    Kindsvogel, W.2    Busby, S.3    Bailey, M.C.4    Shi, Y.5    Greenberg, P.D.6
  • 7
    • 0031963994 scopus 로고    scopus 로고
    • Activation of low avidity CTL specific for a self-epitope results in tumor rejection but not autoimmunity
    • Morgan, D. J., H. T. Kreuwel, S. Fleck, H. I. Levitsky, D. M. Pardoll, and L. A. Sherman. 1998. Activation of low avidity CTL specific for a self-epitope results in tumor rejection but not autoimmunity. J. Immunol. 160:643.
    • (1998) J. Immunol. , vol.160 , pp. 643
    • Morgan, D.J.1    Kreuwel, H.T.2    Fleck, S.3    Levitsky, H.I.4    Pardoll, D.M.5    Sherman, L.A.6
  • 9
    • 0036784601 scopus 로고    scopus 로고
    • Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen
    • Higgins, A. D., M. A. Mihalyo, and A. J. Adler. 2002. Effector CD4 cells are tolerized upon exposure to parenchymal self-antigen. J. Immunol. 169:3622.
    • (2002) J. Immunol. , vol.169 , pp. 3622
    • Higgins, A.D.1    Mihalyo, M.A.2    Adler, A.J.3
  • 11
    • 0242270657 scopus 로고    scopus 로고
    • Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-α and IFN-γ expression potentials
    • Long, M., A. D. Higgins, M. A. Mihalyo, and A. J. Adler. 2003. Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-α and IFN-γ expression potentials. Cell. Immunol. 224:114.
    • (2003) Cell. Immunol. , vol.224 , pp. 114
    • Long, M.1    Higgins, A.D.2    Mihalyo, M.A.3    Adler, A.J.4
  • 14
    • 0020047427 scopus 로고
    • Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells
    • North, R. J. 1982. Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J. Exp. Med. 155:1063.
    • (1982) J. Exp. Med. , vol.155 , pp. 1063
    • North, R.J.1
  • 15
    • 0021686808 scopus 로고
    • Treatment of disseminated leukemia with cyclophosphamide and immune cells: Tumor immunity reflects long-term persistence of tumor-specific donor T cells
    • Greenberg, P. D., and M. A. Cheever. 1984. Treatment of disseminated leukemia with cyclophosphamide and immune cells: tumor immunity reflects long-term persistence of tumor-specific donor T cells. J. Immunol. 133:3401.
    • (1984) J. Immunol. , vol.133 , pp. 3401
    • Greenberg, P.D.1    Cheever, M.A.2
  • 17
    • 0032518412 scopus 로고    scopus 로고
    • Importance of cyclophosphamide-induced bystander effect on T cells for a successful tumor eradication in response to adoptive immunotherapy in mice
    • Proietti, E., G. Greco, B. Garrone, S. Baccarini, C. Mauri, M. Venditti, D. Carlei, and F. Belardelli. 1998. Importance of cyclophosphamide-induced bystander effect on T cells for a successful tumor eradication in response to adoptive immunotherapy in mice. J. Clin. Invest. 101:429.
    • (1998) J. Clin. Invest. , vol.101 , pp. 429
    • Proietti, E.1    Greco, G.2    Garrone, B.3    Baccarini, S.4    Mauri, C.5    Venditti, M.6    Carlei, D.7    Belardelli, F.8
  • 19
  • 21
    • 0037099515 scopus 로고    scopus 로고
    • Development of antitumor immune responses in reconstituted lymphopenic hosts
    • Hu, H. M., C. H. Poehlein, W. J. Urba, and B. A. Fox. 2002. Development of antitumor immune responses in reconstituted lymphopenic hosts. Cancer Res. 62:3914.
    • (2002) Cancer Res. , vol.62 , pp. 3914
    • Hu, H.M.1    Poehlein, C.H.2    Urba, W.J.3    Fox, B.A.4
  • 23
    • 0035883073 scopus 로고    scopus 로고
    • Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression
    • Sotomayor, E. M., I. Borrello, F. M. Rattis, A. G. Cuenca, J. Abrams, K. Staveley-O'Carroll, and H. I. Levitsky. 2001. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood 98:1070.
    • (2001) Blood , vol.98 , pp. 1070
    • Sotomayor, E.M.1    Borrello, I.2    Rattis, F.M.3    Cuenca, A.G.4    Abrams, J.5    Staveley-O'Carroll, K.6    Levitsky, H.I.7
  • 26
    • 0036604063 scopus 로고    scopus 로고
    • CD4 cell priming and tolerization are differentially programmed by APCs upon initial engagement
    • Higgins, A. D., M. A. Mihalyo, P. W. McGary, and A. J. Adler. 2002. CD4 cell priming and tolerization are differentially programmed by APCs upon initial engagement. J. Immunol. 168:5573.
    • (2002) J. Immunol. , vol.168 , pp. 5573
    • Higgins, A.D.1    Mihalyo, M.A.2    McGary, P.W.3    Adler, A.J.4
  • 27
    • 0035282433 scopus 로고    scopus 로고
    • Visualizing the generation of memory CD4 T cells in the whole body
    • Reinhardt, R. L., A. Khoruts, R. Merica, T. Zell, and M. K. Jenkins, 2001. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101.
    • (2001) Nature , vol.410 , pp. 101
    • Reinhardt, R.L.1    Khoruts, A.2    Merica, R.3    Zell, T.4    Jenkins, M.K.5
  • 29
    • 37049178741 scopus 로고
    • The staphylococcal enterotoxins and their relatives
    • Marrack, P., and J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science 248:705.
    • (1990) Science , vol.248 , pp. 705
    • Marrack, P.1    Kappler, J.2
  • 30
    • 0023118407 scopus 로고
    • Cachectin: More than a tumor necrosis factor
    • Beutler, B., and A. Cerami. 1987. Cachectin: more than a tumor necrosis factor. N. Engl. J. Med. 316:379.
    • (1987) N. Engl. J. Med. , vol.316 , pp. 379
    • Beutler, B.1    Cerami, A.2
  • 32
    • 0035865338 scopus 로고    scopus 로고
    • Autologous regulation of naive T cell homeostasis within the T cell compartment
    • Dummer, W., B. Ernst, E. LeRoy, D. Lee, and C. Surh. 2001. Autologous regulation of naive T cell homeostasis within the T cell compartment. J. Immunol. 166:2460.
    • (2001) J. Immunol. , vol.166 , pp. 2460
    • Dummer, W.1    Ernst, B.2    LeRoy, E.3    Lee, D.4    Surh, C.5
  • 34
    • 0033662405 scopus 로고    scopus 로고
    • + T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN γ receptor expression by nonhematopoietic cells
    • + T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN γ receptor expression by nonhematopoietic cells. Immunity 12:677.
    • (2000) Immunity , vol.12 , pp. 677
    • Qin, Z.1    Blankenstein, T.2
  • 35
    • 0036005884 scopus 로고    scopus 로고
    • The roles of IFN γ in protection against tumor development and cancer immunoediting
    • Ikeda, H., L. J. Old, and R. D. Schreiber. 2002. The roles of IFN γ in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 13:95.
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 95
    • Ikeda, H.1    Old, L.J.2    Schreiber, R.D.3
  • 36
    • 0037442129 scopus 로고    scopus 로고
    • TNF plays an essential role in tumor regression after adoptive transfer of perforin/IFN-γ double knockout effector T cells
    • Poehlein, C. H., H. M. Hu, J. Yamada, I. Assmann, W. G. Alvord, W. J. Urba, and B. A. Fox. 2003. TNF plays an essential role in tumor regression after adoptive transfer of perforin/IFN-γ double knockout effector T cells. J. Immunol. 170:2004.
    • (2003) J. Immunol. , vol.170 , pp. 2004
    • Poehlein, C.H.1    Hu, H.M.2    Yamada, J.3    Assmann, I.4    Alvord, W.G.5    Urba, W.J.6    Fox, B.A.7
  • 37
    • 0035877073 scopus 로고    scopus 로고
    • Immunotherapy of melanoma: A dichotomy in the requirement for IFN-γ in vaccine-induced antitumor immunity versus adoptive immunotherapy
    • Winter, H., H. M. Hu, K. McClain, W. J. Urba, and B. A. Fox. 2001. Immunotherapy of melanoma: a dichotomy in the requirement for IFN-γ in vaccine-induced antitumor immunity versus adoptive immunotherapy. J. Immunol. 166:7370.
    • (2001) J. Immunol. , vol.166 , pp. 7370
    • Winter, H.1    Hu, H.M.2    McClain, K.3    Urba, W.J.4    Fox, B.A.5
  • 38
    • 0038350933 scopus 로고    scopus 로고
    • Successful elimination of large established tumors and avoidance of antigen-loss variants by aggressive adoptive T cell immunotherapy
    • Matsui, K., L. A. O'Mara, and P. M. Allen. 2003. Successful elimination of large established tumors and avoidance of antigen-loss variants by aggressive adoptive T cell immunotherapy. Int. Immunol. 15:797.
    • (2003) Int. Immunol. , vol.15 , pp. 797
    • Matsui, K.1    O'Mara, L.A.2    Allen, P.M.3
  • 40
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmumty: Viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmumty: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
    • (1995) Cell , vol.80 , pp. 695
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 47
    • 0025754853 scopus 로고
    • Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
    • Oldstone, M. B., M. Nerenberg, P. Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65:319.
    • (1991) Cell , vol.65 , pp. 319
    • Oldstone, M.B.1    Nerenberg, M.2    Southern, P.3    Price, J.4    Lewicki, H.5
  • 48
    • 0029812040 scopus 로고    scopus 로고
    • Constitutive class I-restricted exogenous presentation of self antigens in vivo
    • Kurts, C., W. R. Heath, F. R. Carbone, J. Allison, J. F. Miller, and H. Kosaka. 1996. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184:923.
    • (1996) J. Exp. Med. , vol.184 , pp. 923
    • Kurts, C.1    Heath, W.R.2    Carbone, F.R.3    Allison, J.4    Miller, J.F.5    Kosaka, H.6
  • 51
    • 0022597114 scopus 로고
    • Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide
    • Berd, D., H. C. Maguire, Jr., and M. J. Mastrangelo. 1986. Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide. Cancer Res. 46:2572.
    • (1986) Cancer Res. , vol.46 , pp. 2572
    • Berd, D.1    Maguire Jr., H.C.2    Mastrangelo, M.J.3
  • 53
    • 0035328683 scopus 로고    scopus 로고
    • Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice
    • Machiels, J. P., R. T. Reilly, L. A. Emens, A. M. Ercolini, R. Y. Lei, D. Weintraub, F. I. Okoye, and E. M. Jaffee. 2001. Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice. Cancer Res. 61:3689.
    • (2001) Cancer Res. , vol.61 , pp. 3689
    • Machiels, J.P.1    Reilly, R.T.2    Emens, L.A.3    Ercolini, A.M.4    Lei, R.Y.5    Weintraub, D.6    Okoye, F.I.7    Jaffee, E.M.8
  • 55
    • 0345447666 scopus 로고    scopus 로고
    • IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion
    • D'Souza, W. N., and L. Lefrancois. 2003. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J. Immunol. 171:5727.
    • (2003) J. Immunol. , vol.171 , pp. 5727
    • D'Souza, W.N.1    Lefrancois, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.