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Stephan, W.1
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of special interest. See annotation [7].
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Nachman MW, Churchill G. Heterogeneity in rates of recombination across the mouse genome. of special interest Genetics. 142:1996;537-548 See annotation [7].
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Nachman, M.W.1
Churchill, G.2
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7
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0030726434
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Patterns of DNA variability at X-linked loci in Mus domesticus
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of special interest. These two papers [6, 7] document the heterogeneity in rates of recombination across the mouse genome and provide evidence that levels of DNA variation are positively correlated with recombination. This result significantly extends the generality of the correlation seen in Drosophila.
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Nachman MW. Patterns of DNA variability at X-linked loci in Mus domesticus. of special interest Genetics. 147:1997;1303-1316 These two papers [6, 7] document the heterogeneity in rates of recombination across the mouse genome and provide evidence that levels of DNA variation are positively correlated with recombination. This result significantly extends the generality of the correlation seen in Drosophila.
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Nachman, M.W.1
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8
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0029910525
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High nucleotide sequence variation in a region of low recombination in Drosophila simulans is consistent with the background selection model
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of special interest. The importance of knowledge of differences in rates of recombination in different species is demonstrated in this study of DNA sequence variation in D. simulans, a sibling species of D. melanogaster that has a higher average rate of recombination.
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Hamblin MT, Aquadro CF. High nucleotide sequence variation in a region of low recombination in Drosophila simulans is consistent with the background selection model. of special interest Mol Biol Evol. 13:1996;1133-1140 The importance of knowledge of differences in rates of recombination in different species is demonstrated in this study of DNA sequence variation in D. simulans, a sibling species of D. melanogaster that has a higher average rate of recombination.
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Hamblin, M.T.1
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Intraspecific nuclear DNA variation in Drosophila
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of special interest. The authors provide a thorough summary of within-species estimates of synonymous, non-synonymous, and non-coding nucleotide variation for all available nuclear DNA sequences for D. melanogaster, D. simulans and D. pseudoobscura. Tests of departure from neutrality show that about half of the loci depart from the expectations of strict neutrality. Hypotheses to explain general patterns of variation within and between species are reviewed.
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Moriyama EN, Powell JR. Intraspecific nuclear DNA variation in Drosophila. of special interest Mol Biol Evol. 13:1996;261-277 The authors provide a thorough summary of within-species estimates of synonymous, non-synonymous, and non-coding nucleotide variation for all available nuclear DNA sequences for D. melanogaster, D. simulans and D. pseudoobscura. Tests of departure from neutrality show that about half of the loci depart from the expectations of strict neutrality. Hypotheses to explain general patterns of variation within and between species are reviewed.
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Mol Biol Evol
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Moriyama, E.N.1
Powell, J.R.2
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The speciation history of Drosophila pseudoobscura and close relatives: Inferences from DNA sequence variation at the period locus
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Wang R-L, Hey J. The speciation history of Drosophila pseudoobscura and close relatives: inferences from DNA sequence variation at the period locus. Genetics. 144:1996;1113-1126.
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Wang, R.-L.1
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Wells RS. Nucleotide variation at the Gpdh locus in the genus Drosophila. Genetics. 143:1996;375-384.
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True JR, Mercer JM, Laurie CC. Differences in crossover frequency and distribution among three sibling species of Drosophila. Genetics. 142:1996;507-523.
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Fernandez, J.1
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of outstanding interest. A thoughtful and detailed exploration of the ability of background selection to explain the positive correlation between DNA variation and rates of recombination across the Drosophila genome. The author incorporates detailed genetic map data as well as the observed distribution of transposable elements which tend to be clustered in regions of low recombination and contribute to the mutational load (and thus background selection) in these regions.
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Charlesworth B. Background selection and patterns of genetic diversity in Drosophila melanogaster. of outstanding interest Genet Res. 68:1996;131-149 A thoughtful and detailed exploration of the ability of background selection to explain the positive correlation between DNA variation and rates of recombination across the Drosophila genome. The author incorporates detailed genetic map data as well as the observed distribution of transposable elements which tend to be clustered in regions of low recombination and contribute to the mutational load (and thus background selection) in these regions.
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Hamblin MT, Aquadro CF. Contrasting patterns of nucleotide sequence variation at the glucose dehydrogenase (Gld) locus in different populations of Drosophila melanogaster. Genetics. 145:1997;1053-1062.
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Hamblin, M.T.1
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Rates of DNA sequence evolution are not sex-biased in Drosophila melanogaster and D. simulans
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in press
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Bauer VL, Aquadro CF. Rates of DNA sequence evolution are not sex-biased in Drosophila melanogaster and D. simulans. Mol Biol Evol. 1997;. in press.
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-6) than has been reported for humans, mice and other mammals. The lower rate is hypothesized to be associated, perhaps causally, with the small average size of these tandem repeats in Drosophila.
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Length variation of CAG-CAA trinucleotide repeats in natural populations of Drosophila melanogaster and its relation to the recombination rate
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of special interest. These authors examine trinucleotide repeat microsatellite variation in several European and African populations of D. melanogaster and find no correlation between variation and recombination rate. They interpret their result as reflecting the impact of selective sweeps caused by fixations of linked advantageous mutations.
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Michalakis Y, Veuille M. Length variation of CAG-CAA trinucleotide repeats in natural populations of Drosophila melanogaster and its relation to the recombination rate. of special interest Genetics. 143:1996;1713-1725 These authors examine trinucleotide repeat microsatellite variation in several European and African populations of D. melanogaster and find no correlation between variation and recombination rate. They interpret their result as reflecting the impact of selective sweeps caused by fixations of linked advantageous mutations.
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Michalakis, Y.1
Veuille, M.2
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1842294030
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Polymorphism and locus-specific effects on polymorphism at microsatellite loci in natural Drosophila melanogaster populations
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of outstanding interest. Microsatellite variation is surveyed in several natural population samples from the world-wide distribution of D. melanogaster. The particularly striking result is the finding that numerous loci have dramatically reduced variation in only one or two localities, despite high levels of variation for these same loci in other populations. These results appear to reflect a high frequency of local adaptive fixation linked to these microsatellites, perhaps associated with movement of the species out of Africa into new habitats.
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Schloetterer C, Vogl C, Tautz D. Polymorphism and locus-specific effects on polymorphism at microsatellite loci in natural Drosophila melanogaster populations. of outstanding interest Genetics. 146:1997;309-320 Microsatellite variation is surveyed in several natural population samples from the world-wide distribution of D. melanogaster. The particularly striking result is the finding that numerous loci have dramatically reduced variation in only one or two localities, despite high levels of variation for these same loci in other populations. These results appear to reflect a high frequency of local adaptive fixation linked to these microsatellites, perhaps associated with movement of the species out of Africa into new habitats.
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Tautz, D.3
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Schug, M.D.1
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Fu, Y.X.1
Li, W.H.2
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of outstanding interest. The authors present and analyze 349 copies of a 3 kb region including the β-globin gene of humans sampled from Africa, Asia and Europe. Using a new method, they estimate the coalescent time for this gene to be on the order of 800,000 years and that the effective population size of humans has been -10,000 over this period. They also show that selection acting at this locus in malarial regions has been recent and has not substantially affected the distribution of DNA variation from that expected under neutrality.
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Harding RM, Fullerton SM, Griffiths RC, Bond J, Cox MJ, Schneider JA, Moulin DS, Clegg JB. Archaic African and Asian lineages in the genetic ancestry of modern humans. of outstanding interest Am J Hum Genet. 60:1997;772-789 The authors present and analyze 349 copies of a 3 kb region including the β-globin gene of humans sampled from Africa, Asia and Europe. Using a new method, they estimate the coalescent time for this gene to be on the order of 800,000 years and that the effective population size of humans has been -10,000 over this period. They also show that selection acting at this locus in malarial regions has been recent and has not substantially affected the distribution of DNA variation from that expected under neutrality.
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Kelly JK. A test of neutrality based on interlocus associations. Genetics. 146:1997;1197-1206.
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of special interest. Evidence of species-specific differences in purifying selection at silent sites and of a burst of adaptive fixation of amino acid replacements at the G6pd locus, possibly associated with differences in species effective population sizes, is revealed by a careful analysis of DNA sequence variation within and between African, European, and North American populations of Drosophila melanogaster and D. simulans.
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Eanes WF, Kirchner M, Yoon J, Biermann CH, Wang IN, McCartney MA, Verrelli BC. Historical selection, amino acid polymorphism and lineage-specific divergence at the G6pd locus in Drosophila melanogaster and D. simulans. of special interest Genetics. 144:1996;1027-1041 Evidence of species-specific differences in purifying selection at silent sites and of a burst of adaptive fixation of amino acid replacements at the G6pd locus, possibly associated with differences in species effective population sizes, is revealed by a careful analysis of DNA sequence variation within and between African, European, and North American populations of Drosophila melanogaster and D. simulans.
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Eanes, W.F.1
Kirchner, M.2
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Biermann, C.H.4
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Verrelli, B.C.7
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of special interest. A direct experimental test for compensatory interactions of nucleotide substitutions within the alcohol dehydrogenase gene transcript of D. melanogaster. Variants within evolutionarily conserved regions leading to secondary structures are shown to affect Adh activity epistatically. Such interactions are proposed as an explanation for clusters of linkage disequilibrium seen in this gene in natural populations.
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Parsch J, Tanda S, Stephan W. Site-directed mutations reveal long-range compensatory interactions in the Adh gene of Drosophila melanogaster. of special interest Proc Natl Acad Sci USA. 94:1997;928-933 A direct experimental test for compensatory interactions of nucleotide substitutions within the alcohol dehydrogenase gene transcript of D. melanogaster. Variants within evolutionarily conserved regions leading to secondary structures are shown to affect Adh activity epistatically. Such interactions are proposed as an explanation for clusters of linkage disequilibrium seen in this gene in natural populations.
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