Undermining the endothelium by ablation of MAPK-MEF2 signaling

Journal of Clinical Investigation

Volumn 113, Issue 8, 2004, Pages 1110-1112

  Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MYOCYTE ENHANCER FACTOR 2;

CELL PROLIFERATION; CELL SURVIVAL; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE DELETION; IN VITRO STUDY; MOLECULAR BIOLOGY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL SURVIVAL; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; INSULIN RESISTANCE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 7; MITOGEN-ACTIVATED PROTEIN KINASES; MYOGENIC REGULATORY FACTORS; TRANSCRIPTION FACTORS;

EID: 2142705800     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200421497     Document Type: Review

References (20)

1. Raman, M., and Cobb, M.H. 2003. MAP kinase modules: many roads home. Curr. Biol. 13:R886-R888.
2. Kasler, H.G., Victoria, J., Duramad, O., and Winoto, A. 2000 ERK5 is a novel type of mitogen activated protein kinase containing a transcriptional activation domain Mol. Cell Biol. 20:8382-8389.
3. Yang, C.C., Ornatsky, O.I., McDermott, J.C., Cruz, T.F., and Prody, C.A. 1998. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERKS/BMK1. Nucleic Acid Res. 26:4771-4777.
4. Marinissen, M.J., Chiariello, M., Pallante, M., and Gutkind, J.S. 1999. A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38, and extracellular signal-regulated kinase 5. Mol. Cell Biol. 19:4289-4301.
5. Fukuhara, S., Marinissen, M.J., Chiariello, M., and Gurkind, J.S. 2000. Signaling from G protein-coupled receptors to ERKS/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras and Rho-independent pathway. J. Biol. Chem. 275:21730-21736.
6. Kato, Y., et al. 2000. Big mitogen-activated protein kinase regulates multiple members of the MEF2 protein family. J. Biol. Chem. 275:18534-18540.
7. McKinsey, T.A., Zhang, C.L., and Olson, E.N. 2002. MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends Biochem. Sci. 27:40-47.
8. Regan, C.P., et al. 2002. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc. Natl. Acad. Sci. U. S. A. 99:9248-9253.
9. Sohn, S.J., Sarvis, B.K., Cado, D., and Winoto, A. 2002. ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia sensitive repressor of vascular endothelial growth factor expression. J. Biol. Chem. 277:43344-43351.
10. Yang, J., et al. 2000. Mekk3 is essential for early embryonic cardiovascular development. Natl. Genet. 24:309-313.
11. Lin, Q., Schwarz, J., Bucana, C., and Olson, E.N. 1997. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 276:1404-1407.
12. Lin, Q., et al. 1998. Requirement of the MADS-box transcription factor MEF2C for vascular development. Development. 125:4565-4574.
13. Bi, W., Drake, C.J., and Schwarz, J.J. 1999. The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev. Biol. 211:255-267.
14. Hayashi, M., et al. 2004. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J. Clin. Invest. 113:1138-1148. doi:10.1172/JCI200419890.
15. Liu, L., et al. 2003. ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but nor mature cortical neurons. Proc. Natl. Acad. Sci. U. S. A. 100:8532-8537.
16. 2+//calmodulin-dependent kinase 11 promotes depolarization-mediated cerebellar granule neuron survival. J. Biol. Chem. 278:41472-41481.
17. Mao, Z., Bonni, A., Xia, F., Nadal-Vicens, M., and Greenberg, M.E. 1999. Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science. 286:785-790.
18. Li, M., et al. 2001. Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J. Neurosci. 21:6544-6552.
19. Pi, X., Yan, C., and Berk, B.C. 2004. Big mirogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis. Circ. Res. 94:362-369.
20. Wang, L., Fan, C., Topol, S.E., Topol, S.E., Topol, E.J., and Wang, Q. 2003. Mutation of MEF2A in an inherited disorder with features of coronary artery disease Science 302:1578-1581.