Streptozotocin alters pancreatic beta-cell responsiveness to glucose within six hours of injection into rats

West Indian Medical Journal

Volumn 45, Issue 2, 1996, Pages 60-62

  West, E ^a   Simon, O R ^a   Morrison, E Y St A ^a  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HISTOLOGY; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; INSULIN; ISLETS OF LANGERHANS; MALE; RATS; RATS, WISTAR; STREPTOZOCIN;

EID: 0030056631     PISSN: 00433144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Black, H E., Rosenblum, I.Y and Capen, C C (1980) Chemically induced (streptozotocin-alloxan) diabetes mellitus in the dog; Biochemical and ultrastructural studies. Am. J Pathol 98: 295-305
2. Iwase, M , Nunoi, K., Wakisaka, M et al (1991) Spontaneous recovery from non-insulin-dependent diabetes mellitus induced by neonatal streptozotocin treatment in spontaneously hypertensive rats. Metabolism, 40: 10-14.
3. Panagiotidis, G., Akesson, B., Rydell, E L and Lundquist, I. (1995) Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues. Br. J. Pharmacol. 114: 289-296.
4. Papaccio, G., Linn, T. and Chieffi-Baccari, G. (1993) Morphological observations on pancreatic islet blood vessels in low-dose streptozotocintreated mice. J. Anat. 182: 45-53.
5. Simon, O.K. and West, M.E (1992) Unstable diabetic state produced by a small dose of streptozotocin in rats. West Ind. Med J., 41: 146-149.
6. Swanston-Flatt, S.K., Day, C , Baily, C J and Flatt P R (1990) Traditional plant treatment for diabetes. Studies in normal and streptozotocin-diabetic mice. Diahetologia, 33: 462-464.
7. Uchigata, Y., Yamamoto, H., Nagai, H. and Okamoto, H (1983) Effect of poly (ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis. Diabetes, 32: 316-318